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> Protein (NX_Q86U70)
Protein (NX_Q86U70)
Protein
Gene SymbolLDB1 to neXtProt (NX_Q86U70)
DescriptionLIM domain-binding protein 1
Chromosome10
Location10q24.32 (103867317 ~ 103880210) to Ensembl
Sequene Features : Isoforms 3, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of hemoglobin biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
  + 18 more...
.protein homodimerization activity
.LIM domain binding
.enzyme binding
  + 4 more...
.protein complex
.transcription factor complex
.nucleus
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 45 4
2014-09-19protein level
3 35 4
2014-05-27protein level
3 35 4
2014-02-25protein level
3 35 4
2013-12-09protein level
3 27 4
2013-11-01protein level
3 25 4
2013-09-12protein level
3 25 4
2013-08-17protein level
3 25 4
2013-07-15protein level
3 19 3
2013-06-11protein level
3 19 3
2013-02-12protein level
3 11 6
2012-12-20protein level
3 11 6
2012-10-30protein level
3 14 6
2012-10-07protein level
3 14 2
2012-08-24protein level
3 8 2
2012-07-28protein level
3 8 2
2012-06-08protein level
3 2 2
2012-05-07protein level
3 2 2
2012-04-10protein level
3 2 2
2012-01-13protein level
3 2 2
2011-12-20protein level
3 5 2
2011-11-11protein level
3 5 2
2011-08-23protein level
3 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86U70-1
2 12 2 46502.2669
NX_Q86U70-2
0 12 2 42781.5782
NX_Q86U70-3
1 9 2 36403.8032
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-677177,EBI-10258690 LMX1B  
  .dopaminergic neuron differentiation
.positive regulation of transcription from RNA polymerase II promoter
.organ growth
  + 14 more...
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.nucleus
2 EBI-677177,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
3 EBI-677177,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
4 EBI-677177,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
5 EBI-677177,EBI-8474075 LHX8  
  .odontogenesis of dentin-containing tooth
.forebrain neuron development
.female gonad development
  + 3 more...
.sequence-specific DNA binding
.zinc ion binding
.female germ cell nucleus
6 EBI-677177,EBI-2902395 SSBP3  
  .positive regulation of anterior head development
.head morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.single-stranded DNA binding .protein complex
.nucleus
7 EBI-677177,EBI-10258746 LHX6  
  .cell maturation
.forebrain neuron fate commitment
.cerebral cortex GABAergic interneuron migration
  + 3 more...
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood32
bone41
bone marrow20
brain17
cervix61
connective tissue20
embryonic tissue28
esophagus49
eye28
heart89
intestine34
kidney4
larynx42
liver9
lung65
lymph node55
mammary gland39
mouth45
muscle37
ovary49
pancreas32
parathyroid242
placenta7
prostate21
skin66
stomach10
testis25
thymus37
thyroid21
tonsil58
uterus38
vascular19
Health State
TissuesTPM*
normal25
bladder carcinoma170
breast (mammary gland) tumor32
chondrosarcoma60
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
germ cell tumor11
glioma55
head and neck tumor44
kidney tumor14
leukemia42
liver tumor10
lung tumor116
non-neoplasia31
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
prostate cancer38
retinoblastoma43
skin tumor71
soft tissue/muscle tissue tumor47
uterine tumor55
Developmental Stage
TissuesTPM*
adult33
embryoid body14
blastocyst32
fetus70
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.8
adrenal gland25.9
appendix30.9
bone marrow53.1
cerebral cortex29.3
colon19.1
duodenum20.9
esophagus27.7
gallbladder40.5
heart muscle36.5
kidney30.2
liver8.6
lung39.6
lymph node42.8
ovary84.4
pancreas10.4
placenta35.7
prostate37.9
salivary gland36.9
skin82.9
small intestine21.2
spleen47.3
stomach24.9
testis28.1
thyroid gland38.3
urinary bladder35.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603451, gene) Lim domain-binding 1; LDB1OMIM


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