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> Protein (NX_Q86UW9)
Protein (NX_Q86UW9)
Protein
Gene SymbolDTX2 to neXtProt (NX_Q86UW9)
DescriptionProbable E3 ubiquitin-protein ligase DTX2
Chromosome7
Location7q11.23 (76090993 ~ 76135312) to Ensembl
Sequene Features : Isoforms 2, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 68 7
2014-09-19protein level
2 58 7
2014-05-27protein level
2 58 7
2014-02-25protein level
2 57 4
2013-12-09protein level
2 52 4
2013-11-01protein level
2 49 3
2013-09-12protein level
2 49 3
2013-08-17protein level
2 49 3
2013-07-15protein level
2 36 0
2013-06-11protein level
2 36 0
2013-02-12protein level
2 25 3
2012-12-20protein level
2 25 3
2012-10-30protein level
2 26 3
2012-10-07protein level
2 26 2
2012-08-24protein level
2 25 2
2012-07-28protein level
2 25 2
2012-06-08protein level
2 25 2
2012-05-07protein level
2 22 2
2012-04-10protein level
2 22 2
2012-01-13protein level
2 10 2
2011-12-20protein level
2 10 2
2011-11-11protein level
2 10 2
2011-08-23protein level
2 10 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86UW9-1
3 20 0 67203.1788
NX_Q86UW9-2
1 20 0 62304.5229
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740376,EBI-10200283 HDC  
  .small molecule metabolic process
.catecholamine biosynthetic process
.cellular nitrogen compound metabolic process
  + 3 more...
.pyridoxal phosphate binding
.histidine decarboxylase activity
.cytosol
2 EBI-740376,EBI-10209725 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
3 EBI-740376,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
4 EBI-740376,EBI-749635 NCALD  
  .calcium-mediated signaling
.vesicle-mediated transport
.synaptic transmission
.regulation of systemic arterial blood pressure
.clathrin binding
.tubulin binding
.calcium ion binding
.actin binding
.extracellular exosome
.clathrin coat of trans-Golgi network vesicle
.cytosol
.intracellular
5 EBI-740376,EBI-746987 NCS1  
  .phosphatidylinositol-mediated signaling
.positive regulation of exocytosis
.regulation of neuron projection development
.calcium ion binding
.voltage-gated calcium channel activity
.magnesium ion binding
.extracellular exosome
.perinuclear region of cytoplasm
.postsynaptic membrane
  + 10 more...
6 EBI-740376,EBI-740943 VSNL1  
  .calcium-mediated signaling .calcium ion binding .N/A
7 EBI-740376,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
8 EBI-740376,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-740376,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
10 EBI-740376,EBI-742673 SEC23B  
  .vesicle-mediated transport
.ER to Golgi vesicle-mediated transport
.intracellular protein transport
.zinc ion binding .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 5 more...
11 EBI-740376,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
12 EBI-740376,EBI-946029 C1orf94  
  .N/A .N/A .N/A
13 EBI-740376,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
14 EBI-740376,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
15 EBI-740376,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
16 EBI-740376,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
17 EBI-740376,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
18 EBI-740376,EBI-8652744 SEC22A  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
19 EBI-740376,EBI-954419 SPAG8  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of protein binding
.N/A .membrane
.nucleus
.acrosomal vesicle
20 EBI-740376,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
21 EBI-740376,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
22 EBI-740376,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
23 EBI-740376,EBI-8637516 ALKBH4  
  .cleavage furrow ingression
.actomyosin structure organization
.protein demethylation
  + 2 more...
.metal ion binding
.demethylase activity
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.actin binding
.contractile ring
.midbody
.cytoplasm
.nucleus
24 EBI-740376,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
25 EBI-740376,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder100
blood114
bone27
bone marrow20
brain31
cervix103
connective tissue33
embryonic tissue9
eye67
heart11
intestine90
kidney56
liver14
lung35
lymph67
lymph node11
mammary gland46
mouth317
muscle75
ovary88
pancreas60
placenta49
prostate94
salivary gland49
skin28
spleen56
stomach125
testis225
thymus150
thyroid21
trachea77
umbilical cord72
uterus30
vascular19
Health State
TissuesTPM*
normal43
bladder carcinoma113
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma24
colorectal tumor62
gastrointestinal tumor118
germ cell tumor56
glioma65
head and neck tumor149
kidney tumor29
leukemia116
liver tumor20
lung tumor38
lymphoma124
non-neoplasia51
ovarian tumor78
pancreatic tumor28
primitive neuroectodermal tumor of the CNS62
prostate cancer115
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult57
blastocyst32
neonate96
fetus17
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.2
adrenal gland3.8
appendix11.3
bone marrow3.9
cerebral cortex2
colon12.4
duodenum9.5
esophagus34.9
gallbladder10.4
heart muscle3.6
kidney3.4
liver2.9
lung10.2
lymph node13
ovary4.4
pancreas4.8
placenta5.9
prostate8.2
salivary gland11.6
skin28.6
small intestine9.8
spleen11.7
stomach14.5
testis23.5
thyroid gland4.5
urinary bladder12.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613141, gene) Deltex, drosophila, homolog of, 2; DTX2OMIM


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