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> Protein (NX_Q86V21)
Protein (NX_Q86V21)
Protein
Gene SymbolAACS to neXtProt (NX_Q86V21)
DescriptionAcetoacetyl-CoA synthetase
Chromosome12
Location12q24.31 (125549925 ~ 125627873) to Ensembl
Sequene Features : Isoforms 3, Variants 99, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to cholesterol
.cellular response to testosterone stimulus
.cellular response to glucose stimulus
  + 11 more...
.butyrate-CoA ligase activity
.acetoacetate-CoA ligase activity
.ATP binding
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 99 1
2014-09-19protein level
3 77 1
2014-05-27protein level
3 74 1
2014-02-25protein level
3 73 1
2013-12-09protein level
3 51 1
2013-11-01protein level
3 48 0
2013-09-12protein level
3 48 1
2013-08-17protein level
3 48 1
2013-07-15protein level
3 33 1
2013-06-11protein level
3 33 1
2013-02-12protein level
3 21 3
2012-12-20protein level
3 22 3
2012-10-30protein level
3 25 3
2012-10-07protein level
3 25 1
2012-08-24protein level
3 25 1
2012-07-28protein level
3 25 1
2012-06-08protein level
3 31 1
2012-05-07protein level
3 25 1
2012-04-10protein level
3 25 1
2012-01-13protein level
3 12 1
2011-12-20protein level
3 12 1
2011-11-11protein level
3 12 1
2011-08-23protein level
3 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86V21-1
0 29 0 75095.779
NX_Q86V21-2
2 23 0 66991.3372
NX_Q86V21-3
1 13 0 30042.1428
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10259474,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder33
bone13
bone marrow20
brain82
cervix123
connective tissue26
embryonic tissue28
esophagus49
eye71
heart11
intestine47
kidney71
liver43
lung41
lymph225
mammary gland105
mouth256
muscle47
ovary29
pancreas23
parathyroid145
pharynx49
pituitary gland121
placenta24
prostate131
skin71
stomach20
testis98
thymus62
thyroid85
trachea231
uterus38
vascular38
Health State
TissuesTPM*
normal50
breast (mammary gland) tumor118
cervical tumor86
chondrosarcoma24
colorectal tumor71
esophageal tumor57
gastrointestinal tumor16
germ cell tumor60
glioma27
head and neck tumor149
kidney tumor145
liver tumor93
lung tumor19
lymphoma138
non-neoplasia20
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer134
retinoblastoma129
skin tumor23
soft tissue/muscle tissue tumor63
uterine tumor11
Developmental Stage
TissuesTPM*
adult50
embryoid body57
blastocyst32
neonate32
fetus55
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.7
adrenal gland6.2
appendix6.4
bone marrow3.2
cerebral cortex18.5
colon13.7
duodenum17.2
esophagus19.8
gallbladder9.4
heart muscle5.8
kidney9.9
liver2
lung7.1
lymph node6.6
ovary6.2
pancreas5.1
placenta6.9
prostate9.7
salivary gland37.1
skin31.7
small intestine9.6
spleen4.4
stomach17.7
testis19.7
thyroid gland12.1
urinary bladder7.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1High
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614364, gene) Acetoacetyl-coa synthetase; AACSOMIM


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