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> Protein (NX_Q86V42)
Protein (NX_Q86V42)
Protein
Gene SymbolFAM124A to neXtProt (NX_Q86V42)
DescriptionProtein FAM124A
Chromosome13
Location13q14.3 (51796503 ~ 51858377) to Ensembl
Sequene Features : Isoforms 3, Variants 79, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 79 0
2014-09-19protein level
3 64 0
2014-05-27protein level
3 64 0
2014-02-25protein level
3 63 0
2013-12-09protein level
3 51 0
2013-11-01protein level
3 48 0
2013-09-12protein level
3 48 0
2013-08-17protein level
3 48 0
2013-07-15protein level
3 34 0
2013-06-11protein level
3 34 0
2013-02-12protein level
3 20 0
2012-12-20protein level
3 21 0
2012-10-30protein level
3 21 0
2012-10-07protein level
3 21 0
2012-08-24transcript level
3 20 0
2012-07-28transcript level
3 20 0
2012-06-08transcript level
3 3 0
2012-05-07transcript level
3 3 0
2012-04-10transcript level
3 3 0
2012-01-13transcript level
3 3 0
2011-12-20transcript level
3 9 0
2011-11-11transcript level
3 9 0
2011-08-23transcript level
3 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86V42-1
0 23 0 60066.6085
NX_Q86V42-2
3 22 0 64317.5459
NX_Q86V42-3
3 10 0 33983.1285
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744506,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
2 EBI-744506,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
3 EBI-744506,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
4 EBI-744506,EBI-876651 ROCK1  
  .regulation of cell motility
.regulation of establishment of cell polarity
.positive regulation of focal adhesion assembly
  + 27 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.bleb
.lamellipodium
.plasma membrane
  + 5 more...
5 EBI-744506,EBI-3952014 PRKG1  
  .activation of mitophagy in response to mitochondrial depolarization
.negative regulation of platelet aggregation
.relaxation of vascular smooth muscle
  + 9 more...
.cGMP binding
.ATP binding
.calcium channel regulator activity
.cGMP-dependent protein kinase activity
.plasma membrane
.cytosol
.Golgi apparatus
.cytoplasm
6 EBI-744506,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
7 EBI-744506,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
8 EBI-744506,EBI-2795524 ZZZ3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin organization
.zinc ion binding
.chromatin binding
.DNA binding
.nuclear membrane
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
9 EBI-744506,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
10 EBI-744506,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
11 EBI-744506,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
12 EBI-744506,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
13 EBI-744506,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
14 EBI-744506,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
15 EBI-744506,EBI-745680 STAC3  
  .skeletal muscle fiber development
.intracellular signal transduction
.neuromuscular synaptic transmission
.skeletal muscle contraction
.metal ion binding
.identical protein binding
.N/A
16 EBI-744506,EBI-747844 RAB3IP  
  .positive regulation of GTPase activity
.cilium assembly
.protein localization to organelle
  + 3 more...
.Rab guanyl-nucleotide exchange factor activity .ciliary basal body
.lamellipodium
.cytoskeleton
  + 3 more...
17 EBI-744506,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
18 EBI-744506,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
19 EBI-744506,EBI-711679 ZFP64  
  .positive regulation of mRNA splicing, via spliceosome
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
20 EBI-744506,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
21 EBI-744506,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
22 EBI-744506,EBI-723153 CGGBP1  
  .negative regulation of transcription from RNA polymerase II promoter .double-stranded DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain39
connective tissue13
embryonic tissue14
eye38
intestine8
kidney42
liver19
lung14
muscle9
ovary19
pancreas4
placenta10
prostate5
skin4
testis20
thyroid21
uterus25
vascular19
Health State
TissuesTPM*
normal23
chondrosarcoma24
germ cell tumor53
glioma46
kidney tumor14
liver tumor10
lung tumor9
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
retinoblastoma86
skin tumor7
Developmental Stage
TissuesTPM*
adult13
blastocyst48
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.2
adrenal gland1.6
appendix2.4
cerebral cortex7.1
colon1.4
esophagus1
gallbladder1.9
heart muscle2.4
kidney3.4
lung1.8
placenta1.9
prostate2.2
salivary gland4.7
spleen8
thyroid gland1.4
urinary bladder2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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