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> Protein (NX_Q86VP1)
Protein (NX_Q86VP1)
Protein
Gene SymbolTAX1BP1 to neXtProt (NX_Q86VP1)
DescriptionTax1-binding protein 1
Chromosome7
Location7p15.2 (27778950 ~ 27884183) to Ensembl
Sequene Features : Isoforms 4, Variants 80, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 80 6
2014-09-19protein level
4 65 6
2014-05-27protein level
4 65 6
2014-02-25protein level
4 66 6
2013-12-09protein level
4 52 6
2013-11-01protein level
4 52 4
2013-09-12protein level
4 52 4
2013-08-17protein level
4 52 4
2013-07-15protein level
4 33 4
2013-06-11protein level
4 33 4
2013-02-12protein level
3 15 9
2012-12-20protein level
3 15 9
2012-10-30protein level
3 16 9
2012-10-07protein level
3 16 3
2012-08-24protein level
3 15 3
2012-07-28protein level
3 15 3
2012-06-08protein level
3 18 3
2012-05-07protein level
3 14 3
2012-04-10protein level
3 14 3
2012-01-13protein level
3 12 3
2011-12-20protein level
3 12 3
2011-11-11protein level
3 12 2
2011-08-23protein level
3 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86VP1-1
3 35 0 90819.6319
NX_Q86VP1-2
0 36 0 86202.5157
NX_Q86VP1-3
0 31 0 65071.0949
NX_Q86VP1-4
0 31 0 68233.8652
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-529518,EBI-740058 LGALS8  
  .T cell costimulation
.plasma cell differentiation
.carbohydrate binding .extracellular exosome
.membrane
.cytoplasm
.extracellular space
2 EBI-529518,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-529518,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
4 EBI-529518,EBI-745191 DSTN  
  .actin filament severing
.positive regulation of actin filament depolymerization
.actin filament depolymerization
.actin polymerization or depolymerization
.N/A .extracellular exosome
.cortical actin cytoskeleton
.actin cytoskeleton
5 EBI-529518,EBI-389534 COG7  
  .protein stabilization
.protein localization to Golgi apparatus
.protein localization to organelle
  + 3 more...
.N/A .intracellular membrane-bounded organelle
.Golgi transport complex
.Golgi apparatus
  + 2 more...
6 EBI-529518,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
7 EBI-529518,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
8 EBI-529518,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
9 EBI-529518,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
10 EBI-529518,EBI-2210673 SSX2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
11 EBI-529518,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
12 EBI-529518,EBI-742259 LMO3  
  .positive regulation of glucocorticoid receptor signaling pathway
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of fat cell differentiation
  + 3 more...
.zinc ion binding .cytoplasm
13 EBI-529518,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
14 EBI-529518,EBI-2513715 MRPL53  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.N/A .ribosome
.mitochondrial inner membrane
15 EBI-529518,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
16 EBI-529518,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
17 EBI-529518,EBI-3956892 FOXC2  
  .negative regulation of apoptotic process involved in outflow tract morphogenesis
.positive regulation of cell migration involved in sprouting angiogenesis
.glomerular mesangial cell development
  + 34 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 3 more...
.nucleus
18 EBI-529518,EBI-722247 RAB18  
  .endoplasmic reticulum tubular network organization
.lipid particle organization
.Rab protein signal transduction
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.endoplasmic reticulum tubular network
.extracellular exosome
.plasma membrane
  + 2 more...
19 EBI-529518,EBI-2339393 RAD18  
  .negative regulation of DNA recombination
.DNA damage response, detection of DNA damage
.translesion synthesis
  + 5 more...
.ubiquitin protein ligase activity
.single-stranded DNA-dependent ATPase activity
.ubiquitin protein ligase binding
  + 5 more...
.Rad6-Rad18 complex
.replication fork
.nucleoplasm
  + 3 more...
20 EBI-529518,EBI-10315485 NMRK1  
  .NAD biosynthetic process .ribosylnicotinamide kinase activity
.metal ion binding
.ATP binding
.N/A
21 EBI-529518,EBI-949911 CXXC1  
  .histone H3-K4 methylation
.positive regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 4 more...
.unmethylated CpG binding
.zinc ion binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nuclear speck
  + 4 more...
22 EBI-529518,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
23 EBI-529518,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
24 EBI-529518,EBI-465487 STARD13  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.lipid binding
.GTPase activator activity
.mitochondrial membrane
.cytosol
.lipid particle
25 EBI-529518,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
26 EBI-529518,EBI-744586 EMILIN1  
  .extracellular matrix organization
.positive regulation of cell-substrate adhesion
.cell adhesion
.extracellular matrix constituent conferring elasticity .extracellular exosome
.extracellular matrix
.collagen trimer
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland333
ascites276
bladder234
blood106
bone111
bone marrow184
brain107
cervix206
connective tissue174
ear62
embryonic tissue131
esophagus248
eye81
heart145
intestine168
kidney227
liver160
lung176
lymph45
lymph node44
mammary gland92
mouth226
muscle94
nerve64
ovary128
pancreas121
parathyroid194
pharynx147
pituitary gland363
placenta204
prostate100
salivary gland98
skin227
spleen131
stomach188
testis133
thymus150
thyroid171
trachea251
umbilical cord290
uterus193
vascular367
Health State
TissuesTPM*
normal139
adrenal tumor632
bladder carcinoma113
breast (mammary gland) tumor118
cervical tumor144
chondrosarcoma120
colorectal tumor159
esophageal tumor289
gastrointestinal tumor210
germ cell tumor140
glioma74
head and neck tumor156
kidney tumor232
leukemia95
liver tumor239
lung tumor87
lymphoma27
non-neoplasia82
ovarian tumor131
pancreatic tumor114
primitive neuroectodermal tumor of the CNS39
prostate cancer105
retinoblastoma129
skin tumor295
soft tissue/muscle tissue tumor191
uterine tumor177
Developmental Stage
TissuesTPM*
adult146
embryoid body171
blastocyst113
neonate257
fetus125
infant127
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue47.1
adrenal gland110.2
appendix57.7
bone marrow63.9
cerebral cortex67.4
colon73.2
duodenum57.5
esophagus113.3
gallbladder79.6
heart muscle97
kidney80.1
liver41.8
lung61.5
lymph node56.2
ovary53.4
pancreas33.6
placenta94.6
prostate75.4
salivary gland66.2
skin48.1
small intestine62.8
spleen56.4
stomach64.8
testis80
thyroid gland98.5
urinary bladder95.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605326, gene) Tax1-binding protein 1; TAX1BP1OMIM


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