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> Protein (NX_Q86XK2)
Protein (NX_Q86XK2)
Protein
Gene SymbolFBXO11 to neXtProt (NX_Q86XK2)
DescriptionF-box only protein 11
Chromosome2
Location2p16.3 (48016455 ~ 48132932) to Ensembl
Sequene Features : Isoforms 6, Variants 100, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-arginine N-methylation
.protein ubiquitination
.sensory perception of sound
  + 2 more...
.protein-arginine N-methyltransferase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleolus
.chromosome
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 100 1
2014-09-19protein level
6 73 1
2014-05-27protein level
6 73 1
2014-02-25protein level
6 72 1
2013-12-09protein level
6 69 1
2013-11-01protein level
6 65 1
2013-09-12protein level
6 60 1
2013-08-17protein level
6 60 1
2013-07-15protein level
6 30 0
2013-06-11protein level
6 30 0
2013-02-12protein level
6 11 0
2012-12-20protein level
6 11 0
2012-10-30protein level
6 12 0
2012-10-07protein level
6 12 0
2012-08-24protein level
5 6 0
2012-07-28protein level
5 6 0
2012-06-08protein level
5 5 0
2012-05-07protein level
5 5 0
2012-04-10protein level
5 5 0
2012-01-13protein level
5 5 0
2011-12-20protein level
5 5 0
2011-11-11protein level
5 5 0
2011-08-23protein level
5 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86XK2-1
0 40 0 103519.2779
NX_Q86XK2-2
3 22 0 62378.2355
NX_Q86XK2-3
0 26 0 65516.7919
NX_Q86XK2-4
1 6 0 23426.7549
NX_Q86XK2-5
1 40 0 106795.9063
NX_Q86XK2-6
0 39 0 93996.4905
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1047804,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-1047804,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
blood40
bone41
bone marrow102
brain64
cervix61
embryonic tissue61
eye71
heart44
intestine17
kidney61
liver38
lung62
lymph22
lymph node133
mammary gland19
mouth15
muscle56
nerve64
ovary68
pancreas56
parathyroid339
pharynx49
placenta35
prostate26
skin33
spleen37
stomach10
testis78
thymus37
thyroid128
trachea154
uterus56
vascular38
Health State
TissuesTPM*
normal62
bladder carcinoma113
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor8
germ cell tumor91
glioma18
head and neck tumor52
kidney tumor43
leukemia63
liver tumor41
lymphoma41
non-neoplasia31
ovarian tumor65
pancreatic tumor9
prostate cancer38
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult59
embryoid body100
fetus82
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.4
adrenal gland27.7
appendix31.5
bone marrow32.7
cerebral cortex38
colon24
duodenum21.1
esophagus24
gallbladder28.8
heart muscle20.1
kidney23.3
liver18.4
lung28.2
lymph node35.4
ovary39.4
pancreas11.3
placenta25.7
prostate25.3
salivary gland15.1
skin25.6
small intestine22.4
spleen30.4
stomach23.6
testis48.5
thyroid gland29.5
urinary bladder28.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607871, gene) F-box only protein 11; FBXO11OMIM
2diffuse large B-cell lymphomaCGP


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