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> Protein (NX_Q86XK3)
Protein (NX_Q86XK3)
Protein
Gene SymbolSFR1 to neXtProt (NX_Q86XK3)
DescriptionSwi5-dependent recombination DNA repair protein 1 homolog
Chromosome10
Location10q25.1 (105881816 ~ 105886143) to Ensembl
Sequene Features : Isoforms 3, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 15 1
2014-09-19protein level
3 18 1
2014-05-27protein level
3 18 1
2014-02-25protein level
3 18 1
2013-12-09protein level
3 11 1
2013-11-01protein level
3 10 1
2013-09-12protein level
3 10 3
2013-08-17protein level
3 10 3
2013-07-15protein level
3 9 3
2013-06-11protein level
3 9 3
2013-02-12protein level
3 3 9
2012-12-20protein level
3 3 9
2012-10-30protein level
3 5 9
2012-10-07protein level
3 5 3
2012-08-24protein level
3 5 3
2012-07-28protein level
3 5 3
2012-06-08protein level
3 6 3
2012-05-07protein level
3 5 3
2012-04-10protein level
3 5 3
2012-01-13protein level
3 4 3
2011-12-20protein level
3 4 3
2011-11-11protein level
3 4 3
2011-08-23protein level
3 4 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86XK3-1
0 10 0 28244.1507
NX_Q86XK3-2
3 10 0 35916.3144
NX_Q86XK3-3
0 10 0 26718.4676
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1104535,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-1104535,EBI-744408 RNF40  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
3 EBI-1104535,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
4 EBI-1104535,EBI-10212206 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
5 EBI-1104535,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
6 EBI-1104535,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
7 EBI-1104535,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
8 EBI-1104535,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood8
bone41
bone marrow41
brain8
connective tissue20
embryonic tissue4
eye9
kidney4
larynx42
liver9
lung5
lymph node11
mammary gland6
pancreas4
pharynx24
prostate5
skin18
stomach10
testis45
vascular38
Health State
TissuesTPM*
normal8
breast (mammary gland) tumor10
chondrosarcoma24
gastrointestinal tumor16
germ cell tumor18
head and neck tumor7
liver tumor10
non-neoplasia31
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
skin tumor7
Developmental Stage
TissuesTPM*
adult8
blastocyst16
fetus5
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.4
adrenal gland4.4
appendix8.2
bone marrow7.1
cerebral cortex7
colon6
duodenum5
esophagus4.8
gallbladder5.8
heart muscle6.4
kidney4.9
liver1.7
lung6.9
lymph node9.4
ovary9.7
pancreas2.9
placenta4.4
prostate4.2
salivary gland3.3
skin4
small intestine6.3
spleen6.7
stomach6.7
testis18.9
thyroid gland7.7
urinary bladder7.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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