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> Protein (NX_Q86XR8)
Protein (NX_Q86XR8)
Protein
Gene SymbolCEP57 to neXtProt (NX_Q86XR8)
DescriptionCentrosomal protein of 57 kDa
Chromosome11
Location11q21 (95523129 ~ 95565857) to Ensembl
Sequene Features : Isoforms 5, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 49 7
2014-09-19protein level
5 43 7
2014-05-27protein level
5 43 7
2014-02-25protein level
5 40 7
2013-12-09protein level
5 30 7
2013-11-01protein level
5 29 7
2013-09-12protein level
5 29 7
2013-08-17protein level
5 29 7
2013-07-15protein level
4 18 1
2013-06-11protein level
4 18 1
2013-02-12protein level
4 14 7
2012-12-20protein level
4 13 7
2012-10-30protein level
4 18 7
2012-10-07protein level
4 18 2
2012-08-24protein level
4 17 2
2012-07-28protein level
4 17 2
2012-06-08protein level
4 22 2
2012-05-07protein level
4 19 2
2012-04-10protein level
4 19 2
2012-01-13protein level
4 10 2
2011-12-20protein level
4 10 2
2011-11-11protein level
4 10 2
2011-08-23protein level
4 10 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86XR8-1
0 21 0 57053.3439
NX_Q86XR8-2
0 19 0 54129.9147
NX_Q86XR8-3
0 12 0 31127.8988
NX_Q86XR8-4
1 20 0 55990.9422
NX_Q86XR8-5
0 21 0 56455.1108
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-308614,EBI-1050253 CTAGE5  
  .positive regulation of catalytic activity .enzyme activator activity .membrane
2 EBI-308614,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
3 EBI-308614,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-308614,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
5 EBI-308614,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-308614,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-308614,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
8 EBI-308614,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
9 EBI-308614,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
bladder66
blood89
bone111
bone marrow123
brain33
cervix268
connective tissue73
ear62
embryonic tissue93
esophagus148
eye43
heart67
intestine25
kidney47
liver48
lung47
lymph node189
mammary gland39
muscle65
nerve128
ovary49
pancreas37
pharynx98
pituitary gland60
placenta52
prostate42
skin28
stomach62
testis62
thymus138
tonsil58
uterus81
vascular19
Health State
TissuesTPM*
normal63
adrenal tumor158
breast (mammary gland) tumor21
cervical tumor376
chondrosarcoma96
colorectal tumor26
esophageal tumor115
gastrointestinal tumor50
germ cell tumor49
glioma18
head and neck tumor29
kidney tumor29
leukemia84
liver tumor52
lung tumor38
lymphoma69
non-neoplasia51
ovarian tumor39
primitive neuroectodermal tumor of the CNS118
prostate cancer38
retinoblastoma64
skin tumor23
soft tissue/muscle tissue tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult64
embryoid body100
blastocyst97
neonate96
fetus78
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.5
adrenal gland17.2
appendix26.3
bone marrow21.7
cerebral cortex15.7
colon20.4
duodenum33.3
esophagus18.8
gallbladder35.9
heart muscle16.1
kidney17
liver25
lung21.7
lymph node36.8
ovary37.5
pancreas12.4
placenta18.1
prostate19.2
salivary gland12.9
skin20.3
small intestine25
spleen23.5
stomach21.2
testis46.1
thyroid gland29.6
urinary bladder25.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607951, gene) Centrosomal protein, 57-kd; CEP57OMIM
2(#614114, phenotype) Mosaic variegated aneuploidy syndrome 2; MVA2OMIM


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