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> Protein (NX_Q86Y07)
Protein (NX_Q86Y07)
Protein
Gene SymbolVRK2 to neXtProt (NX_Q86Y07)
DescriptionSerine/threonine-protein kinase VRK2
Chromosome2
Location2p16.1 (58134786 ~ 58387055) to Ensembl
Sequene Features : Isoforms 5, Variants 71, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of interleukin-1-mediated signaling pathway
.protein autophosphorylation
.regulation of MAPK cascade
  + 7 more...
.protein domain specific binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.protein complex
.mitochondrial membrane
.integral component of membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 71 2
2014-09-19protein level
5 58 2
2014-05-27protein level
5 58 2
2014-02-25protein level
5 58 2
2013-12-09protein level
5 46 2
2013-11-01protein level
5 46 2
2013-09-12protein level
5 46 2
2013-08-17protein level
5 46 2
2013-07-15protein level
5 35 2
2013-06-11protein level
5 35 2
2013-02-12protein level
5 18 5
2012-12-20protein level
5 18 5
2012-10-30protein level
5 22 5
2012-10-07protein level
5 22 1
2012-08-24protein level
5 22 1
2012-07-28protein level
5 22 1
2012-06-08protein level
5 5 1
2012-05-07protein level
5 5 1
2012-04-10protein level
5 5 1
2012-01-13protein level
5 5 1
2011-12-20protein level
5 5 1
2011-11-11protein level
5 5 1
2011-08-23protein level
5 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86Y07-1
0 25 0 58103.6223
NX_Q86Y07-2
1 20 0 45001.1
NX_Q86Y07-3
1 23 0 55411.1889
NX_Q86Y07-4
0 20 0 44382.4061
NX_Q86Y07-5
1 20 0 45005.1213
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1207633,EBI-286642 RAN  
  .protein localization to nucleolus
.intracellular transport of virus
.cell division
  + 21 more...
.androgen receptor binding
.poly(A) RNA binding
.GDP binding
  + 4 more...
.extracellular exosome
.recycling endosome
.RNA nuclear export complex
  + 10 more...
2 EBI-1207633,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
3 EBI-1207633,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
4 EBI-1207636,EBI-716258 NFATC2  
  .B cell receptor signaling pathway
.positive regulation of transcription, DNA-templated
.innate immune response
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nuclear transcription factor complex
.ribonucleoprotein complex
.actin cytoskeleton
  + 5 more...
5 EBI-1207615,EBI-486984 KSR1  
  .positive regulation of MAPK cascade
.Ras protein signal transduction
.metal ion binding
.protein C-terminus binding
.ATP binding
.protein kinase activity
.protein complex
.membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood16
bone27
bone marrow20
brain3
cervix20
connective tissue40
embryonic tissue14
heart11
intestine30
kidney4
larynx42
liver14
lung14
lymph45
lymph node66
mammary gland13
muscle9
ovary49
pancreas23
pharynx49
pituitary gland60
placenta35
prostate68
skin47
spleen18
stomach10
testis39
trachea77
uterus4
vascular19
Health State
TissuesTPM*
normal27
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma36
colorectal tumor35
germ cell tumor7
head and neck tumor14
kidney tumor14
leukemia10
lung tumor29
lymphoma96
non-neoplasia10
ovarian tumor65
pancreatic tumor9
prostate cancer115
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult26
embryoid body14
neonate32
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland11.5
appendix19.1
bone marrow11.4
cerebral cortex4.9
colon13.2
duodenum8.6
esophagus18.7
gallbladder11.3
heart muscle12
kidney9
liver7.5
lung12.4
lymph node20
ovary9.5
pancreas8.1
placenta11.9
prostate12.4
salivary gland9.5
skin9.2
small intestine9.1
spleen14.2
stomach11.2
testis15.4
thyroid gland16.4
urinary bladder16.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602169, gene) Vaccinia-related kinase 2; VRK2OMIM


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