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> Protein (NX_Q86YT6)
Protein (NX_Q86YT6)
Protein
Gene SymbolMIB1 to neXtProt (NX_Q86YT6)
DescriptionE3 ubiquitin-protein ligase MIB1
Chromosome18
Location18q11.2 (19284918 ~ 19450918) to Ensembl
Sequene Features : Isoforms 1, Variants 97, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endocytosis
.negative regulation of neuron differentiation
.protein ubiquitination
  + 7 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasmic vesicle
.postsynaptic density
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 97 22
2014-09-19protein level
1 68 22
2014-05-27protein level
1 68 22
2014-02-25protein level
1 68 22
2013-12-09protein level
1 57 22
2013-11-01protein level
1 56 18
2013-09-12protein level
1 56 18
2013-08-17protein level
1 56 18
2013-07-15protein level
1 30 2
2013-06-11protein level
1 30 2
2013-02-12protein level
1 9 2
2012-12-20protein level
1 10 2
2012-10-30protein level
1 14 2
2012-10-07protein level
1 14 2
2012-08-24protein level
1 14 2
2012-07-28protein level
1 14 2
2012-06-08protein level
1 16 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 8 2
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23transcript level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86YT6-1
49 0 1 110065.4326
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2129148,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder100
bone69
bone marrow41
brain32
cervix61
connective tissue53
ear186
embryonic tissue61
eye90
heart33
intestine17
kidney94
larynx42
liver24
lung44
lymph45
lymph node233
mammary gland33
mouth60
muscle169
ovary9
pancreas46
parathyroid194
pharynx24
pituitary gland60
placenta60
prostate137
salivary gland49
skin47
spleen74
stomach20
testis4
thymus12
thyroid150
trachea38
uterus51
vascular58
Health State
TissuesTPM*
normal64
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma84
gastrointestinal tumor25
germ cell tumor7
glioma27
head and neck tumor52
kidney tumor101
liver tumor10
lung tumor38
lymphoma27
non-neoplasia31
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer231
retinoblastoma193
skin tumor31
soft tissue/muscle tissue tumor111
uterine tumor33
Developmental Stage
TissuesTPM*
adult52
embryoid body42
blastocyst16
fetus141
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.5
adrenal gland7.3
appendix7.3
bone marrow4
cerebral cortex11.5
colon8.9
duodenum5.3
esophagus9.6
gallbladder10.4
heart muscle5.5
kidney12
liver6.7
lung8.2
lymph node8.5
ovary12.8
pancreas4.5
placenta10
prostate10.4
salivary gland7.4
skin8.5
small intestine5.5
spleen6.9
stomach7.9
testis11.2
thyroid gland15.1
urinary bladder9.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608677, gene) Mindbomb, drosophila, homolog of, 1; MIB1OMIM


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