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> Protein (NX_Q8HWS3)
Protein (NX_Q8HWS3)
Protein
Gene SymbolRFX6 to neXtProt (NX_Q8HWS3)
DescriptionDNA-binding protein RFX6
Chromosome6
Location6q22.1 (117198375 ~ 117253326) to Ensembl
Sequene Features : Isoforms 1, Variants 179, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 179 0
2014-09-19protein level
1 120 0
2014-05-27protein level
1 120 0
2014-02-25protein level
1 117 0
2013-12-09protein level
1 102 0
2013-11-01protein level
1 87 0
2013-09-12protein level
1 87 0
2013-08-17protein level
1 87 0
2013-07-15protein level
1 66 0
2013-06-11protein level
1 66 0
2013-02-12protein level
1 33 0
2012-12-20protein level
1 32 0
2012-10-30protein level
1 38 0
2012-10-07protein level
1 38 0
2012-08-24protein level
1 33 0
2012-07-28protein level
1 33 0
2012-06-08protein level
1 34 0
2012-05-07protein level
1 25 0
2012-04-10protein level
1 25 0
2012-01-13protein level
1 11 0
2011-12-20protein level
1 11 0
2011-11-11protein level
1 11 0
2011-08-23protein level
1 11 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8HWS3-1
33 0 0 102395.2473
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746118,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-746118,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
3 EBI-746118,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
4 EBI-746118,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
5 EBI-746118,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
6 EBI-746118,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
7 EBI-746118,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
8 EBI-746118,EBI-2108053 NEDD9  
  .cell division
.actin filament bundle assembly
.regulation of growth
  + 5 more...
.N/A .lamellipodium
.cell cortex
.focal adhesion
  + 5 more...
9 EBI-746118,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
10 EBI-746118,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
11 EBI-746118,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
connective tissue13
liver4
lung2
pancreas56
prostate5
testis2
Health State
TissuesTPM*
normal4
adrenal tumor79
liver tumor10
prostate cancer9
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult2
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland5.1
duodenum1.8
pancreas1.1
small intestine1.3
stomach8.4
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bronchusLow
cerebellumLow
cerebral cortexMedium
colonMedium
epididymisLow
fallopian tubeMedium
gallbladderLow
kidneyLow
lateral ventricleMedium
liverLow
lungLow
nasopharynxMedium
oral mucosaLow
pancreasHigh
rectumMedium
skin 1Medium
small intestineLow
smooth muscleLow
stomach 1Medium
stomach 2Medium
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612659, gene) Regulatory factor x, 6; RFX6OMIM


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