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> Protein (NX_Q8IUH5)
Protein (NX_Q8IUH5)
Protein
Gene SymbolZDHHC17 to neXtProt (NX_Q8IUH5)
DescriptionPalmitoyltransferase ZDHHC17
Chromosome12
Location12q21.2 (77157368 ~ 77247476) to Ensembl
Sequene Features : Isoforms 3, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 54 0
2014-09-19protein level
3 40 0
2014-05-27protein level
3 40 0
2014-02-25protein level
3 40 0
2013-12-09protein level
3 37 0
2013-11-01protein level
3 36 0
2013-09-12protein level
3 36 1
2013-08-17protein level
3 36 1
2013-07-15protein level
3 22 1
2013-06-11protein level
3 22 1
2013-02-12protein level
3 4 3
2012-12-20protein level
3 2 3
2012-10-30protein level
3 4 3
2012-10-07protein level
3 4 1
2012-08-24protein level
3 4 1
2012-07-28protein level
3 4 1
2012-06-08protein level
3 10 1
2012-05-07protein level
3 8 1
2012-04-10protein level
3 8 1
2012-01-13protein level
3 8 1
2011-12-20protein level
3 8 1
2011-11-11protein level
3 8 1
2011-08-23protein level
3 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IUH5-1
15 11 1 72591.7558
NX_Q8IUH5-2
1 8 1 23925.0537
NX_Q8IUH5-3
0 8 1 22829.9401
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-524753,EBI-745000 SNAP23  
  .membrane fusion
.membrane organization
.synaptic vesicle fusion to presynaptic membrane
  + 5 more...
.syntaxin binding
.SNAP receptor activity
.extracellular exosome
.synapse
.neuron projection
  + 8 more...
2 EBI-524753,EBI-9087775 PDPK1  
  .extrinsic apoptotic signaling pathway
.positive regulation of establishment of protein localization to plasma membrane
.cellular response to epidermal growth factor stimulus
  + 38 more...
.phospholipase binding
.kinase activity
.phospholipase activator activity
  + 3 more...
.cell projection
.cytoplasmic membrane-bounded vesicle
.focal adhesion
  + 4 more...
3 EBI-524753,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
4 EBI-524753,EBI-3915857 KLK8  
  .synapse organization
.regulation of synapse organization
.neuron projection morphogenesis
  + 6 more...
.serine-type endopeptidase activity .cytoplasm
.extracellular space
5 EBI-524753,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
6 EBI-524753,EBI-1028956 CAPN2  
  .cellular response to amino acid stimulus
.proteolysis involved in cellular protein catabolic process
.regulation of cytoskeleton organization
  + 5 more...
.cysteine-type peptidase activity
.cytoskeletal protein binding
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.perinuclear endoplasmic reticulum
.extracellular exosome
.membrane raft
  + 11 more...
7 EBI-524753,EBI-9090282 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
8 EBI-524753,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
9 EBI-524753,EBI-9087876 CSNK1D  
  .positive regulation of canonical Wnt signaling pathway
.spindle assembly
.regulation of circadian rhythm
  + 13 more...
.tau-protein kinase activity
.peptide binding
.ATP binding
  + 2 more...
.perinuclear region of cytoplasm
.plasma membrane
.spindle microtubule
  + 5 more...
10 EBI-524753,EBI-1044067 GSK3A  
  .positive regulation of glycogen (starch) synthase activity
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 33 more...
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
.ATP binding
.protein serine/threonine kinase activity
.beta-catenin destruction complex
.cytosol
11 EBI-524753,EBI-7187133 GPM6A  
  .positive regulation of filopodium assembly
.stem cell differentiation
.neuron projection morphogenesis
  + 3 more...
.calcium channel activity .extracellular exosome
.axonal growth cone
.dendritic spine
  + 6 more...
12 EBI-524753,EBI-347740 EIF3E  
  .negative regulation of translational initiation
.cellular protein metabolic process
.gene expression
  + 5 more...
.protein N-terminus binding
.poly(A) RNA binding
.translation initiation factor activity
.extracellular exosome
.eukaryotic 48S preinitiation complex
.PML body
  + 7 more...
13 EBI-524753,EBI-524785 SNAP25  
  .long-term synaptic potentiation
.regulation of insulin secretion
.small molecule metabolic process
  + 10 more...
.calcium-dependent protein binding
.syntaxin-1 binding
.SNAP receptor activity
.synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
.perinuclear region of cytoplasm
.neuron projection
  + 9 more...
14 EBI-524753,EBI-352162 EEF1A1  
  .cellular response to epidermal growth factor stimulus
.cellular protein metabolic process
.gene expression
  + 4 more...
.poly(A) RNA binding
.protein kinase binding
.GTP binding
  + 3 more...
.extracellular exosome
.ruffle membrane
.cortical actin cytoskeleton
  + 7 more...
15 EBI-524753,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
16 EBI-524753,EBI-9090666 PDE4D  
  .negative regulation of relaxation of cardiac muscle
.regulation of cell communication by electrical coupling involved in cardiac conduction
.adrenergic receptor signaling pathway involved in positive regulation of heart rate
  + 29 more...
.scaffold protein binding
.ATPase binding
.metal ion binding
  + 8 more...
.calcium channel complex
.myofibril
.apical plasma membrane
  + 5 more...
17 EBI-524753,EBI-9088686 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
18 EBI-524753,EBI-9090795 SETDB1  
  .bone development
.histone H3-K9 trimethylation
.transcription, DNA-templated
  + 3 more...
.histone-lysine N-methyltransferase activity
.zinc ion binding
.DNA binding
.intracellular membrane-bounded organelle
.plasma membrane
.cytoplasm
  + 3 more...
19 EBI-524753,EBI-968374 PPP2R5E  
  .regulation of protein phosphatase type 2A activity
.signal transduction
.protein phosphatase type 2A regulator activity .cytoplasm
.protein phosphatase type 2A complex
20 EBI-524753,EBI-2818084 APBB1IP  
  .platelet activation
.blood coagulation
.signal transduction
.N/A .lamellipodium
.focal adhesion
.plasma membrane
  + 2 more...
21 EBI-524753,EBI-7082156 SPRED2  
  .regulation of protein deacetylation
.positive regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of peptidyl-threonine phosphorylation
  + 2 more...
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.stem cell factor receptor binding
.transport vesicle membrane
.plasma membrane
.cytoplasm
.nucleoplasm
22 EBI-524753,EBI-5235340 SPRED1  
  .regulation of protein deacetylation
.positive regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of phosphatase activity
  + 3 more...
.protein serine/threonine kinase inhibitor activity
.phosphatase binding
.protein kinase binding
.stem cell factor receptor binding
.caveola
.cytoplasm
.nucleoplasm
23 EBI-524753,EBI-9092184 SLC9A9  
  .transmembrane transport
.regulation of pH
.ion transport
.sodium:proton antiporter activity .recycling endosome
.late endosome membrane
.integral component of membrane
24 EBI-524753,EBI-9091197 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
25 EBI-524753,EBI-2511075 USP32  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein deubiquitination
.calcium ion binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.membrane
.Golgi apparatus
.cytoplasm
26 EBI-524753,EBI-9091423 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
27 EBI-524753,EBI-9089467 RAB39B  
  .synapse organization
.Rab protein signal transduction
.vesicle-mediated transport
  + 2 more...
.myosin V binding
.GTP binding
.GTPase activity
.neuron projection
.vesicle
.plasma membrane
  + 2 more...
28 EBI-524753,EBI-9091443 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
29 EBI-524753,EBI-354861 SPRY4  
  .negative regulation of MAP kinase activity
.multicellular organismal development
.N/A .ruffle membrane
.focal adhesion
.Golgi apparatus
.cytoplasm
30 EBI-524753,EBI-4403434 GOLPH3L  
  .positive regulation of protein secretion
.Golgi organization
.phosphatidylinositol-4-phosphate binding .trans-Golgi network membrane
.Golgi cisterna membrane
.Golgi membrane
31 EBI-524753,EBI-2875816 ARFGAP3  
  .positive regulation of GTPase activity
.vesicle-mediated transport
.protein secretion
.intracellular protein transport
.protein transporter activity
.zinc ion binding
.GTPase activator activity
.membrane
.cytosol
.Golgi apparatus
  + 2 more...
32 EBI-524753,EBI-725672 IFT57  
  .left/right pattern formation
.negative regulation of epithelial cell proliferation
.regulation of apoptotic process
  + 10 more...
.DNA binding .ciliary tip
.primary cilium
.dendrite terminus
  + 6 more...
33 EBI-524753,EBI-9089825 PLEKHB1  
  .regulation of cell differentiation
.phototransduction
.multicellular organismal development
.signal transducer activity .integral component of membrane
.cytoplasm
34 EBI-524753,EBI-396453 FEZ2  
  .axon guidance
.nervous system development
.signal transduction
.N/A .N/A
35 EBI-524753,EBI-6448852 EVL  
  .negative regulation of ruffle assembly
.positive regulation of stress fiber assembly
.protein homotetramerization
  + 9 more...
.SH3 domain binding
.profilin binding
.lamellipodium
.membrane
.focal adhesion
  + 3 more...
36 EBI-524753,EBI-9091996 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
37 EBI-524753,EBI-4290615 WASF2  
  .lamellipodium morphogenesis
.negative regulation of stress fiber assembly
.vascular endothelial growth factor receptor signaling pathway
  + 13 more...
.protein complex binding
.actin binding
.extracellular exosome
.SCAR complex
.lamellipodium
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites25
blood16
bone27
bone marrow20
brain60
connective tissue33
ear124
embryonic tissue37
esophagus49
eye52
heart78
intestine8
kidney23
larynx170
liver53
lung20
lymph node55
mouth30
muscle84
ovary9
pancreas14
parathyroid97
placenta38
prostate5
skin14
spleen56
stomach20
testis29
thymus75
thyroid42
trachea19
uterus60
vascular19
Health State
TissuesTPM*
normal54
adrenal tumor79
chondrosarcoma24
esophageal tumor57
gastrointestinal tumor25
germ cell tumor45
glioma27
head and neck tumor52
kidney tumor14
leukemia10
liver tumor62
non-neoplasia20
ovarian tumor13
retinoblastoma21
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult42
blastocyst65
fetus71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.3
adrenal gland21.9
appendix20.2
bone marrow27.8
cerebral cortex33.6
colon11.1
duodenum11.8
esophagus12.9
gallbladder18.3
heart muscle13.2
kidney14.4
liver7.1
lung16.8
lymph node23.4
ovary31.5
pancreas6.6
placenta18.2
prostate21.4
salivary gland9.7
skin13.2
small intestine14.1
spleen21.9
stomach12.9
testis22.6
thyroid gland17.9
urinary bladder15.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
cerebellumMedium
cerebral cortexHigh
colonMedium
duodenumLow
endometrium 1High
endometrium 2High
epididymisMedium
fallopian tubeLow
hippocampusHigh
kidneyLow
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxLow
pancreasLow
placentaHigh
prostateMedium
rectumLow
salivary glandMedium
seminal vesicleHigh
skin 1Medium
skin 2Low
small intestineLow
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607799, gene) Zinc finger dhhc domain-containing protein 17; ZDHHC17OMIM


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