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> Protein (NX_Q8IV04)
Protein (NX_Q8IV04)
Protein
Gene SymbolTBC1D10C to neXtProt (NX_Q8IV04)
DescriptionCarabin
Chromosome11
Location11q13.2 (67171386 ~ 67177560) to Ensembl
Sequene Features : Isoforms 2, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of ERK1 and ERK2 cascade
.negative regulation of NFAT protein import into nucleus
.negative regulation of B cell activation
.retrograde transport, endosome to Golgi
.GTPase activator activity .filopodium membrane
.membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 58 2
2014-09-19protein level
2 46 2
2014-05-27protein level
2 45 2
2014-02-25protein level
2 45 2
2013-12-09protein level
2 28 2
2013-11-01protein level
2 23 2
2013-09-12protein level
2 23 2
2013-08-17protein level
2 23 2
2013-07-15protein level
2 14 1
2013-06-11protein level
2 14 1
2013-02-12protein level
1 4 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 7 0
2012-10-07protein level
1 7 0
2012-08-24protein level
1 7 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 8 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IV04-1
16 5 0 49680.5726
NX_Q8IV04-2
9 5 0 32865.8442
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10261452,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
2 EBI-10261452,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
3 EBI-10261452,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
4 EBI-10261452,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood130
bone13
connective tissue13
intestine8
liver9
lymph22
lymph node111
mammary gland13
muscle9
ovary9
pancreas9
placenta7
spleen74
stomach10
thymus50
tonsil176
uterus4
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor8
leukemia95
liver tumor20
lymphoma124
pancreatic tumor19
uterine tumor11
Developmental Stage
TissuesTPM*
adult20
fetus1
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3
adrenal gland2.2
appendix40.5
bone marrow43.4
colon4.8
duodenum7.8
esophagus3.4
gallbladder8.4
heart muscle1.8
kidney1.1
liver1.6
lung13.2
lymph node86.1
placenta1.4
prostate3.1
salivary gland5.4
skin3.4
small intestine9.8
spleen60.2
stomach12.2
testis1.9
thyroid gland7.4
urinary bladder13.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*610831, gene) Tbc1 domain family, member 10c; TBC1D10COMIM


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