Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q8IVH8)
Protein (NX_Q8IVH8)
Protein
Gene SymbolMAP4K3 to neXtProt (NX_Q8IVH8)
DescriptionMitogen-activated protein kinase kinase kinase kinase 3
Chromosome2
Location2p22.1 (39476407 ~ 39664453) to Ensembl
Sequene Features : Isoforms 3, Variants 118, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of apoptotic process
.intracellular signal transduction
.response to tumor necrosis factor
  + 6 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 118 4
2014-09-19protein level
3 98 4
2014-05-27protein level
3 98 5
2014-02-25protein level
3 99 5
2013-12-09protein level
3 82 5
2013-11-01protein level
3 76 5
2013-09-12protein level
3 76 4
2013-08-17protein level
3 76 4
2013-07-15protein level
3 53 4
2013-06-11protein level
3 53 4
2013-02-12protein level
3 23 9
2012-12-20protein level
3 24 9
2012-10-30protein level
3 25 9
2012-10-07protein level
3 25 3
2012-08-24protein level
3 13 3
2012-07-28protein level
3 12 3
2012-06-08protein level
3 5 3
2012-05-07protein level
3 5 3
2012-04-10protein level
3 5 3
2012-01-13protein level
3 5 3
2011-12-20protein level
3 7 3
2011-11-11protein level
3 7 3
2011-08-23protein level
3 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IVH8-1
0 40 2 101250.8896
NX_Q8IVH8-2
1 38 2 100068.3037
NX_Q8IVH8-3
1 38 2 98890.8513
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1758170,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
2 EBI-1758170,EBI-374762 PRKCQ  
  .positive regulation of T-helper 2 cell activation
.positive regulation of T-helper 17 type immune response
.regulation of platelet aggregation
  + 26 more...
.metal ion binding
.ATP binding
.ubiquitin-protein transferase activity
  + 2 more...
.plasma membrane
.cytosol
.immunological synapse
3 EBI-1758170,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites75
bladder167
bone13
bone marrow20
brain22
connective tissue26
ear124
embryonic tissue42
eye9
heart44
intestine17
kidney42
larynx42
liver29
lung8
lymph node55
mammary gland33
mouth15
muscle28
pancreas4
pharynx24
placenta63
prostate5
skin42
spleen18
stomach52
testis62
thymus12
thyroid21
uterus21
vascular38
Health State
TissuesTPM*
normal36
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor32
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor67
germ cell tumor15
glioma9
head and neck tumor29
leukemia10
lung tumor9
non-neoplasia31
ovarian tumor13
primitive neuroectodermal tumor of the CNS7
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult30
embryoid body57
blastocyst16
fetus48
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14
adrenal gland20.8
appendix8
bone marrow9.5
cerebral cortex16.3
colon12.8
duodenum13
esophagus11.4
gallbladder18.4
heart muscle16.3
kidney21.7
liver8.4
lung16.1
lymph node6.5
ovary21.1
pancreas6.6
placenta24.8
prostate17.6
salivary gland7.7
skin16.6
small intestine15.1
spleen11.6
stomach22.9
testis22.1
thyroid gland27.6
urinary bladder18.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604921, gene) Mitogen-activated protein kinase kinase kinase kinase 3; MAP4K3OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center