Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q8IVS8)
Protein (NX_Q8IVS8)
Protein
Gene SymbolGLYCTK to neXtProt (NX_Q8IVS8)
DescriptionGlycerate kinase
Chromosome3
Location3p21.1 (52321105 ~ 52329272) to Ensembl
Sequene Features : Isoforms 7, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein phosphorylation .glycerate kinase activity
.ATP binding
.mitochondrion
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 68 0
2014-09-19protein level
7 55 0
2014-05-27protein level
7 52 0
2014-02-25protein level
7 51 0
2013-12-09protein level
7 35 0
2013-11-01protein level
7 33 0
2013-09-12protein level
7 33 0
2013-08-17protein level
7 33 0
2013-07-15protein level
7 24 0
2013-06-11protein level
7 24 0
2013-02-12protein level
7 16 0
2012-12-20protein level
7 16 0
2012-10-30protein level
7 20 0
2012-10-07protein level
7 20 0
2012-08-24protein level
7 19 0
2012-07-28protein level
7 20 0
2012-06-08protein level
7 6 0
2012-05-07protein level
7 6 0
2012-04-10protein level
7 6 0
2012-01-13protein level
7 6 0
2011-12-20protein level
7 6 0
2011-11-11protein level
7 6 0
2011-08-23protein level
7 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IVS8-1
0 18 0 55217.9344
NX_Q8IVS8-2
4 9 0 25021.0038
NX_Q8IVS8-3
1 15 0 48245.2591
NX_Q8IVS8-4
0 15 0 38718.652
NX_Q8IVS8-5
2 6 0 25122.2342
NX_Q8IVS8-6
0 4 0 19854.828
NX_Q8IVS8-7
1 10 0 22012.7147
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748515,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-748515,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-748515,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
4 EBI-748515,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-748515,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
6 EBI-748515,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
7 EBI-748515,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
8 EBI-748515,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
9 EBI-748515,EBI-1052544 TUBGCP4  
  .microtubule nucleation
.protein complex assembly
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.structural constituent of cytoskeleton .recycling endosome
.membrane
.microtubule cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone27
brain3
connective tissue6
embryonic tissue14
eye4
intestine17
kidney14
liver43
lung17
lymph node22
mammary gland13
mouth45
pancreas4
placenta21
prostate5
skin9
testis4
thymus12
uterus4
vascular19
Health State
TissuesTPM*
normal15
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor8
germ cell tumor3
glioma9
head and neck tumor22
leukemia21
liver tumor31
lymphoma55
non-neoplasia10
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult15
blastocyst48
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.8
adrenal gland6.1
appendix8.3
bone marrow9
cerebral cortex3.2
colon15
duodenum85.2
esophagus2.2
gallbladder6.6
heart muscle3
kidney36.9
liver116.3
lung5
lymph node10.3
ovary3.9
pancreas2.8
placenta5
prostate3.5
salivary gland3.7
skin2.4
small intestine58.1
spleen7.7
stomach18.3
testis5.6
thyroid gland3.1
urinary bladder4.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#220120, phenotype) D-glyceric aciduriaOMIM
2(*610516, gene) Glycerate kinase; GLYCTKOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center