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> Protein (NX_Q8IVW4)
Protein (NX_Q8IVW4)
Protein
Gene SymbolCDKL3 to neXtProt (NX_Q8IVW4)
DescriptionCyclin-dependent kinase-like 3
Chromosome5
Location5q31.1 (133541305 ~ 133706738) to Ensembl
Sequene Features : Isoforms 2, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 56 0
2014-09-19protein level
2 47 0
2014-05-27protein level
2 47 0
2014-02-25protein level
2 47 0
2013-12-09protein level
2 33 0
2013-11-01protein level
2 33 0
2013-09-12protein level
2 33 0
2013-08-17protein level
2 33 0
2013-07-15protein level
2 18 0
2013-06-11protein level
2 18 0
2013-02-12transcript level
2 9 0
2012-12-20transcript level
2 9 0
2012-10-30transcript level
2 11 0
2012-10-07transcript level
2 11 0
2012-08-24transcript level
2 6 0
2012-07-28transcript level
2 6 0
2012-06-08transcript level
2 7 0
2012-05-07transcript level
2 7 0
2012-04-10transcript level
2 7 0
2012-01-13transcript level
2 6 0
2011-12-20transcript level
2 6 0
2011-11-11transcript level
2 6 0
2011-08-23transcript level
2 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IVW4-1
6 19 1 67470.953
NX_Q8IVW4-2
0 19 1 51532.9118
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3919850,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-3919850,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-3919850,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
4 EBI-3919850,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
5 EBI-3919850,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
6 EBI-3919850,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
7 EBI-3919850,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
8 EBI-3919850,EBI-3044060 ATG4A  
  .protein delipidation
.nucleophagy
.protein processing
  + 6 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
9 EBI-3919850,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
10 EBI-3919850,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
11 EBI-3919850,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
12 EBI-3919850,EBI-10239299 PIH1D3  
  .axonemal dynein complex assembly
.sperm motility
.chaperone binding .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain10
connective tissue13
eye19
heart22
intestine4
kidney18
lung2
placenta3
prostate5
skin9
testis36
trachea19
uterus12
Health State
TissuesTPM*
normal12
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor7
glioma18
non-neoplasia10
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult7
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.7
adrenal gland5.6
appendix1.1
cerebral cortex6.2
colon1.4
duodenum1
esophagus2
gallbladder3
heart muscle5.1
kidney3.4
liver1
lung2.6
lymph node1.6
ovary3
pancreas1.5
placenta1.9
prostate3
salivary gland2.1
skin1.5
small intestine1.2
spleen1.8
testis20
thyroid gland4.1
urinary bladder3.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608459, gene) Cyclin-dependent kinase-like 3; CDKL3OMIM


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