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> Protein (NX_Q8IW41)
Protein (NX_Q8IW41)
Protein
Gene SymbolMAPKAPK5 to neXtProt (NX_Q8IW41)
DescriptionMAP kinase-activated protein kinase 5
Chromosome12
Location12q24.12 (112279782 ~ 112334343) to Ensembl
Sequene Features : Isoforms 2, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.stress-induced premature senescence
.protein autophosphorylation
.negative regulation of TOR signaling
  + 7 more...
.mitogen-activated protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.ATP binding
  + 6 more...
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 40 4
2014-09-19protein level
2 33 4
2014-05-27protein level
2 33 4
2014-02-25protein level
2 34 4
2013-12-09protein level
2 29 4
2013-11-01protein level
2 29 4
2013-09-12protein level
2 29 4
2013-08-17protein level
2 29 4
2013-07-15protein level
2 15 4
2013-06-11protein level
2 15 4
2013-02-12protein level
2 7 10
2012-12-20protein level
2 5 10
2012-10-30protein level
2 7 10
2012-10-07protein level
2 7 5
2012-08-24protein level
2 5 5
2012-07-28protein level
2 5 5
2012-06-08protein level
2 12 5
2012-05-07protein level
2 11 5
2012-04-10protein level
2 11 5
2012-01-13protein level
2 11 5
2011-12-20protein level
2 7 3
2011-11-11protein level
2 7 3
2011-08-23protein level
2 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IW41-1
1 20 0 54185.7254
NX_Q8IW41-2
1 20 0 54000.6096
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1201460,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-1201460,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
3 EBI-1201460,EBI-1384105 MAPK6  
  .signal transduction
.cell cycle
.protein phosphorylation
.MAPK cascade
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder33
blood8
bone69
bone marrow41
brain17
connective tissue13
embryonic tissue18
eye23
heart33
intestine43
kidney28
liver24
lung50
lymph135
lymph node100
mammary gland59
muscle56
ovary9
pancreas4
pharynx24
placenta14
prostate15
skin9
spleen18
stomach62
testis22
thymus62
uterus12
vascular19
Health State
TissuesTPM*
normal28
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma60
colorectal tumor35
gastrointestinal tumor59
germ cell tumor45
glioma37
leukemia63
liver tumor52
lung tumor9
lymphoma96
ovarian tumor13
pancreatic tumor9
skin tumor7
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult27
embryoid body14
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.3
adrenal gland21.7
appendix18.4
bone marrow20.9
cerebral cortex15.1
colon28.2
duodenum28.6
esophagus15.5
gallbladder13.5
heart muscle14.3
kidney19.4
liver11.8
lung18.9
lymph node20.3
ovary19.4
pancreas9.2
placenta20.4
prostate18.2
salivary gland12.8
skin15.4
small intestine28.1
spleen16.3
stomach17.2
testis18.5
thyroid gland20.6
urinary bladder17.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2High
small intestineMedium
smooth muscleLow
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606723, gene) Mitogen-activated protein kinase-activated protein kinase 5; MAPKAPK5OMIM


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