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> Protein (NX_Q8IW45)
Protein (NX_Q8IW45)
Protein
Gene SymbolCARKD to neXtProt (NX_Q8IW45)
DescriptionATP-dependent (S)-NAD(P)H-hydrate dehydratase
Chromosome13
Location13q34 (111267881 ~ 111292340) to Ensembl
Sequene Features : Isoforms 4, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nicotinamide nucleotide metabolic process .ADP-dependent NAD(P)H-hydrate dehydratase activity
.ATP-dependent NAD(P)H-hydrate dehydratase activity
.ATP binding
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 60 3
2014-09-19protein level
4 45 3
2014-05-27protein level
4 42 3
2014-02-25protein level
4 41 3
2013-12-09protein level
4 34 3
2013-11-01protein level
4 34 3
2013-09-12protein level
4 34 3
2013-08-17protein level
4 34 3
2013-07-15protein level
4 26 3
2013-06-11protein level
4 26 3
2013-02-12protein level
4 20 9
2012-12-20protein level
4 20 9
2012-10-30protein level
4 19 9
2012-10-07protein level
4 19 3
2012-08-24protein level
4 18 3
2012-07-28protein level
4 18 3
2012-06-08protein level
4 5 3
2012-05-07protein level
4 5 3
2012-04-10protein level
4 5 3
2012-01-13protein level
4 5 3
2011-12-20protein level
4 5 3
2011-11-11protein level
4 5 3
2011-08-23protein level
3 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IW45-1
0 17 0 36553.0704
NX_Q8IW45-2
5 14 0 41334.8301
NX_Q8IW45-3
1 6 0 13179.513
NX_Q8IW45-4
1 11 0 25183.8592
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8650724,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-8650724,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
3 EBI-8650724,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-8650724,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
5 EBI-8650724,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
6 EBI-8650724,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
7 EBI-8650724,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
8 EBI-8650724,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites150
bladder66
blood49
bone97
bone marrow41
brain235
cervix61
connective tissue73
embryonic tissue37
esophagus148
eye81
heart145
intestine146
kidney128
larynx213
liver141
lung125
lymph22
lymph node155
mammary gland79
mouth559
muscle56
nerve64
ovary68
pancreas117
parathyroid194
pharynx24
pituitary gland60
placenta49
prostate142
salivary gland98
skin71
spleen318
stomach73
testis107
thymus338
thyroid42
trachea135
umbilical cord72
uterus163
vascular116
Health State
TissuesTPM*
normal141
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor86
chondrosarcoma72
colorectal tumor106
esophageal tumor173
gastrointestinal tumor75
germ cell tumor136
glioma111
head and neck tumor313
kidney tumor101
leukemia42
liver tumor239
lung tumor87
lymphoma27
non-neoplasia103
ovarian tumor91
pancreatic tumor114
primitive neuroectodermal tumor of the CNS165
prostate cancer134
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor188
Developmental Stage
TissuesTPM*
adult85
embryoid body57
blastocyst65
neonate193
fetus150
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.3
adrenal gland39
appendix18.5
bone marrow6.3
cerebral cortex29.8
colon20.4
duodenum22.8
esophagus23.2
gallbladder24.4
heart muscle20.6
kidney30.9
liver22.8
lung21.7
lymph node21.1
ovary38.2
pancreas19.7
placenta25.6
prostate28.7
salivary gland17.1
skin26.1
small intestine22.8
spleen23.9
stomach28.8
testis33.7
thyroid gland29.4
urinary bladder23.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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