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> Protein (NX_Q8IWT3)
Protein (NX_Q8IWT3)
Protein
Gene SymbolCUL9 to neXtProt (NX_Q8IWT3)
DescriptionCullin-9
Chromosome6
Location6p21.1 (43149913 ~ 43192325) to Ensembl
Sequene Features : Isoforms 2, Variants 330, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process
.microtubule cytoskeleton organization
.zinc ion binding
.ATP binding
.cullin-RING ubiquitin ligase complex
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 330 6
2014-09-19protein level
2 257 6
2014-05-27protein level
2 257 6
2014-02-25protein level
2 252 6
2013-12-09protein level
2 196 6
2013-11-01protein level
2 189 4
2013-09-12protein level
2 189 4
2013-08-17protein level
2 189 4
2013-07-15protein level
2 121 2
2013-06-11protein level
2 121 2
2013-02-12protein level
2 68 2
2012-12-20protein level
2 64 2
2012-10-30protein level
2 79 2
2012-10-07protein level
2 79 1
2012-08-24protein level
2 75 1
2012-07-28protein level
2 74 1
2012-06-08protein level
2 85 1
2012-05-07protein level
2 63 1
2012-04-10protein level
2 63 1
2012-01-13protein level
2 32 1
2011-12-20protein level
2 32 1
2011-11-11protein level
2 32 1
2011-08-23protein level
2 32 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IWT3-1
6 105 7 281048.6698
NX_Q8IWT3-3
1 105 7 268189.3713
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-311123,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood8
bone13
brain24
cervix41
connective tissue26
embryonic tissue28
esophagus49
eye9
heart11
intestine25
kidney33
liver4
lung41
lymph22
lymph node111
mammary gland19
mouth15
muscle37
nerve64
ovary29
pancreas60
parathyroid48
placenta3
prostate21
skin4
spleen18
stomach20
testis32
thymus112
thyroid21
trachea38
umbilical cord363
uterus12
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma36
colorectal tumor26
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
head and neck tumor14
kidney tumor58
leukemia42
liver tumor10
lung tumor9
lymphoma27
non-neoplasia20
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS15
prostate cancer19
skin tumor7
Developmental Stage
TissuesTPM*
adult27
embryoid body42
blastocyst16
neonate160
fetus26
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8
adrenal gland10.3
appendix16.2
bone marrow17.7
cerebral cortex12.9
colon9.2
duodenum10.4
esophagus8.5
gallbladder10
heart muscle5.2
kidney9.9
liver4.5
lung13.7
lymph node24.4
ovary10.1
pancreas3.8
placenta7.5
prostate9.9
salivary gland9.7
skin38.6
small intestine8.2
spleen23.2
stomach10.1
testis21.3
thyroid gland11.8
urinary bladder12
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607489, gene) Cullin 9; CUL9OMIM


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