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> Protein (NX_Q8IX15)
Protein (NX_Q8IX15)
Protein
Gene SymbolHOMEZ to neXtProt (NX_Q8IX15)
DescriptionHomeobox and leucine zipper protein Homez
Chromosome14
Location14q11.2 (23741666 ~ 23768656) to Ensembl
Sequene Features : Isoforms 2, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 60 3
2014-09-19protein level
2 48 3
2014-05-27protein level
2 48 3
2014-02-25protein level
1 48 3
2013-12-09protein level
1 32 3
2013-11-01protein level
1 31 2
2013-09-12protein level
1 31 2
2013-08-17protein level
1 31 2
2013-07-15protein level
1 20 2
2013-06-11protein level
1 20 2
2013-02-12protein level
1 10 2
2012-12-20protein level
1 7 2
2012-10-30protein level
1 12 2
2012-10-07protein level
1 12 2
2012-08-24protein level
1 8 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 9 2
2012-05-07protein level
1 9 2
2012-04-10protein level
1 9 2
2012-01-13protein level
1 12 2
2011-12-20protein level
1 12 2
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IX15-1
1 19 0 61202.186
NX_Q8IX15-3
0 19 0 61656.5877
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10172004,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-10172004,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
3 EBI-10172004,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
4 EBI-10172004,EBI-373337 RNF8  
  .protein K48-linked ubiquitination
.histone H2A K63-linked ubiquitination
.protein K63-linked ubiquitination
  + 16 more...
.protein homodimerization activity
.histone binding
.ubiquitin protein ligase binding
  + 4 more...
.site of double-strand break
.midbody
.nucleolus
  + 3 more...
5 EBI-10172004,EBI-2795384 ZBTB7A  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
  + 2 more...
.metal ion binding
.histone acetyltransferase binding
.DNA binding
.nucleus
6 EBI-10172004,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
7 EBI-10172004,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
8 EBI-10172004,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
9 EBI-10172004,EBI-473220 SUMO2  
  .positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.PML body
.nucleoplasm
.nucleus
10 EBI-10172004,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
11 EBI-10172004,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
12 EBI-10172004,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
13 EBI-10172004,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
14 EBI-10172004,EBI-742350 TCEB3  
  .positive regulation of viral transcription
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.viral process
  + 4 more...
.DNA binding .elongin complex
.integral component of membrane
.cytoplasm
  + 3 more...
15 EBI-10172004,EBI-6654703 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
16 EBI-10172004,EBI-712181 MAD2L1BP  
  .regulation of exit from mitosis
.mitotic cell cycle checkpoint
.N/A .intracellular membrane-bounded organelle
.spindle
.cytoplasm
  + 2 more...
17 EBI-10172004,EBI-5529649 APITD1  
  .cell division
.CENP-A containing nucleosome assembly
.positive regulation of protein ubiquitination
  + 8 more...
.chromatin binding
.DNA binding
.FANCM-MHF complex
.Fanconi anaemia nuclear complex
.cytosol
  + 2 more...
18 EBI-10172004,EBI-8463848 SMYD1  
  .negative regulation of transcription, DNA-templated
.positive regulation of myoblast differentiation
.skeletal muscle cell differentiation
  + 4 more...
.metal ion binding
.histone-lysine N-methyltransferase activity
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleus
19 EBI-10172004,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
20 EBI-10172004,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
21 EBI-10172004,EBI-394640 MED18  
  .N/A .RNA polymerase II transcription cofactor activity .mediator complex
22 EBI-10172004,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
23 EBI-10172004,EBI-2795449 DNTTIP1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.protein homodimerization activity
.nucleosome binding
.DNA binding
.nucleolus
.nucleoplasm
.nucleus
.histone deacetylase complex
24 EBI-10172004,EBI-745369 DEF6  
  .N/A .N/A .membrane
.cell-cell junction
.plasma membrane
  + 2 more...
25 EBI-10172004,EBI-765426 EBF1  
  .positive regulation of transcription, DNA-templated
.multicellular organismal development
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
26 EBI-10172004,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
bone27
brain9
embryonic tissue14
eye14
intestine12
kidney18
liver9
lung26
lymph67
lymph node33
mammary gland6
mouth30
ovary9
pancreas9
placenta17
prostate5
skin18
spleen18
testis64
thyroid21
uterus17
vascular19
Health State
TissuesTPM*
normal16
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor8
germ cell tumor7
glioma46
head and neck tumor22
leukemia21
liver tumor10
lymphoma41
pancreatic tumor19
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult10
embryoid body14
blastocyst16
fetus7
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.9
adrenal gland4.4
appendix5.4
bone marrow1.8
cerebral cortex3.6
colon7.8
duodenum9.2
esophagus10.5
gallbladder7.9
heart muscle7.7
kidney10
liver3.7
lung6.8
lymph node5.8
ovary10.7
pancreas4.3
placenta5.9
prostate8
salivary gland6.8
skin7.8
small intestine6.3
spleen6
stomach8.6
testis26.7
thyroid gland9.7
urinary bladder12.2
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderMedium
kidneyLow
lateral ventricleLow
liverLow
nasopharynxMedium
oral mucosaLow
pancreasLow
placentaLow
prostateLow
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
soft tissue 2Low
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608119, gene) Homeodomain leucine zipper-containing factorOMIM


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