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> Protein (NX_Q8IXK0)
Protein (NX_Q8IXK0)
Protein
Gene SymbolPHC2 to neXtProt (NX_Q8IXK0)
DescriptionPolyhomeotic-like protein 2
Chromosome1
Location1p35.1 (33789224 ~ 33896653) to Ensembl
Sequene Features : Isoforms 5, Variants 94, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 94 4
2014-09-19protein level
5 77 4
2014-05-27protein level
5 77 4
2014-02-25protein level
5 77 4
2013-12-09protein level
5 68 4
2013-11-01protein level
5 65 4
2013-09-12protein level
5 65 4
2013-08-17protein level
5 65 4
2013-07-15protein level
5 40 4
2013-06-11protein level
5 40 4
2013-02-12protein level
5 26 25
2012-12-20protein level
5 26 25
2012-10-30protein level
5 27 25
2012-10-07protein level
5 27 5
2012-08-24protein level
5 16 5
2012-07-28protein level
5 16 5
2012-06-08protein level
5 19 5
2012-05-07protein level
5 19 5
2012-04-10protein level
5 19 5
2012-01-13protein level
5 13 5
2011-12-20protein level
5 13 5
2011-11-11protein level
5 13 5
2011-08-23protein level
5 13 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IXK0-1
0 26 2 90656.4923
NX_Q8IXK0-2
1 13 2 35736.9823
NX_Q8IXK0-3
3 12 0 30034.1263
NX_Q8IXK0-4
1 25 2 87756.9563
NX_Q8IXK0-5
1 25 2 90755.5604
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713786,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-713786,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
3 EBI-713786,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-713786,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
5 EBI-713786,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
6 EBI-713786,EBI-2341576 BMI1  
  .positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
7 EBI-713786,EBI-2129767 PCGF2  
  .negative regulation of apoptotic signaling pathway
.cellular response to hydrogen peroxide
.embryonic skeletal system morphogenesis
  + 8 more...
.zinc ion binding
.ubiquitin-protein transferase activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.PRC1 complex
.PcG protein complex
.nuclear body
  + 4 more...
8 EBI-713786,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
9 EBI-713786,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
10 EBI-713786,EBI-724442 RWDD2B  
  .N/A .N/A .N/A
11 EBI-713786,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
12 EBI-713786,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
13 EBI-713786,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
14 EBI-713786,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
15 EBI-713786,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
16 EBI-713786,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
17 EBI-713786,EBI-10238936 SYT16  
  .synaptic vesicle exocytosis
.vesicle fusion
.clathrin binding
.syntaxin binding
.phospholipid binding
.calcium ion binding
.plasma membrane
18 EBI-713786,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
19 EBI-713786,EBI-2339807 PCGF3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.nucleoplasm
.nucleus
20 EBI-713786,EBI-10244822 FAM74A1  
  .N/A .N/A .integral component of membrane
21 EBI-713786,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
22 EBI-713786,EBI-2827999 PCGF5  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.centrosome
.nucleolus
.nucleus
23 EBI-713786,EBI-744506 FAM124A  
  .N/A .N/A .N/A
24 EBI-713786,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
25 EBI-713786,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
26 EBI-713786,EBI-6447163 MAGEB6  
  .N/A .N/A .N/A
27 EBI-713786,EBI-10268010 MAB21L3  
  .N/A .N/A .N/A
28 EBI-713786,EBI-751248 FAM13C  
  .N/A .N/A .N/A
29 EBI-713786,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
30 EBI-713786,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
31 EBI-713786,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
32 EBI-713786,EBI-473695 KBTBD7  
  .N/A .N/A .N/A
33 EBI-713786,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
34 EBI-713786,EBI-348259 MCRS1  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 6 more...
.N/A .MLL1 complex
.Ino80 complex
.cell junction
  + 5 more...
35 EBI-713786,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
36 EBI-713786,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
37 EBI-713786,EBI-10293968 PPP1R16B  
  .positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
38 EBI-713786,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
39 EBI-713786,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
40 EBI-713786,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
41 EBI-10304199,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
42 EBI-713786,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
43 EBI-713786,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
44 EBI-713786,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
45 EBI-713786,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
46 EBI-713786,EBI-747398 SFMBT1  
  .negative regulation of muscle organ development
.negative regulation of transcription, DNA-templated
.cell differentiation
  + 3 more...
.histone binding
.transcription corepressor activity
.nucleoplasm
.nucleus
47 EBI-713786,EBI-719554 DRG1  
  .multicellular organismal development
.transcription, DNA-templated
.identical protein binding
.transcription factor binding
.GTP binding
.membrane
.polysome
.cytoplasm
48 EBI-713786,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites200
bladder66
blood114
bone223
bone marrow82
brain91
cervix41
connective tissue40
embryonic tissue126
esophagus99
eye248
heart156
intestine176
kidney118
larynx468
liver141
lung143
lymph90
lymph node178
mammary gland52
mouth15
muscle112
nerve193
ovary216
pancreas243
placenta120
prostate47
salivary gland690
skin313
spleen74
stomach303
testis206
thymus12
thyroid128
tonsil58
trachea19
uterus146
vascular38
Health State
TissuesTPM*
normal99
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma193
colorectal tumor195
esophageal tumor115
gastrointestinal tumor244
germ cell tumor167
glioma149
head and neck tumor231
kidney tumor217
leukemia169
liver tumor281
lung tumor165
lymphoma110
non-neoplasia41
ovarian tumor183
pancreatic tumor266
primitive neuroectodermal tumor of the CNS204
prostate cancer67
retinoblastoma193
skin tumor398
soft tissue/muscle tissue tumor143
uterine tumor199
Developmental Stage
TissuesTPM*
adult120
embryoid body214
blastocyst32
fetus96
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue77.2
adrenal gland57.9
appendix66.5
bone marrow45.4
cerebral cortex36.7
colon40.5
duodenum29
esophagus48.2
gallbladder65.2
heart muscle66.3
kidney48.6
liver31.4
lung52.6
lymph node36.3
ovary54.5
pancreas28.5
placenta51.1
prostate32.9
salivary gland25.9
skin22.4
small intestine31.4
spleen62.9
stomach39
testis63.7
thyroid gland54.6
urinary bladder56.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602979, gene) Polyhomeotic-like 2; PHC2OMIM


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