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> Protein (NX_Q8IY17)
Protein (NX_Q8IY17)
Protein
Gene SymbolPNPLA6 to neXtProt (NX_Q8IY17)
DescriptionNeuropathy target esterase
Chromosome19
Location19p13.2 (7598890 ~ 7626650) to Ensembl
Sequene Features : Isoforms 5, Variants 137, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylcholine metabolic process
.developmental process
.lipid catabolic process
  + 2 more...
.lysophospholipase activity .integral component of membrane
.membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 137 9
2014-09-19protein level
5 98 9
2014-05-27protein level
5 88 9
2014-02-25protein level
5 88 9
2013-12-09protein level
5 75 9
2013-11-01protein level
5 70 7
2013-09-12protein level
5 70 7
2013-08-17protein level
5 70 7
2013-07-15protein level
4 42 6
2013-06-11protein level
4 42 6
2013-02-12protein level
3 21 23
2012-12-20protein level
3 20 17
2012-10-30protein level
3 20 17
2012-10-07protein level
3 20 6
2012-08-24protein level
3 20 6
2012-07-28protein level
3 20 6
2012-06-08protein level
3 25 6
2012-05-07protein level
3 23 6
2012-04-10protein level
3 23 6
2012-01-13protein level
3 22 6
2011-12-20protein level
3 22 6
2011-11-11protein level
3 22 6
2011-08-23protein level
3 22 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IY17-1
0 55 3 149899.7589
NX_Q8IY17-2
0 53 3 146122.9079
NX_Q8IY17-3
0 55 3 149828.722
NX_Q8IY17-4
1 54 3 150858.1816
NX_Q8IY17-5
1 51 3 143260.359
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites50
bladder33
blood32
bone83
bone marrow328
brain216
cervix61
connective tissue80
embryonic tissue79
eye33
heart22
intestine64
kidney66
liver43
lung128
lymph90
lymph node111
mammary gland39
mouth60
nerve128
ovary39
pancreas28
placenta67
prostate52
salivary gland98
skin56
spleen74
stomach10
testis326
thymus87
thyroid21
tonsil58
trachea193
uterus68
vascular58
Health State
TissuesTPM*
normal115
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma156
colorectal tumor26
gastrointestinal tumor84
germ cell tumor163
glioma65
head and neck tumor52
kidney tumor87
leukemia127
liver tumor41
lung tumor155
lymphoma55
non-neoplasia72
pancreatic tumor57
primitive neuroectodermal tumor of the CNS55
prostate cancer77
retinoblastoma21
skin tumor87
uterine tumor66
Developmental Stage
TissuesTPM*
adult69
embryoid body114
blastocyst113
neonate32
fetus53
infant127
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.5
adrenal gland21.1
appendix28.5
bone marrow20.1
cerebral cortex26.2
colon16.1
duodenum23.4
esophagus12
gallbladder16
heart muscle9.7
kidney23.2
liver5.9
lung41
lymph node24.2
ovary13
pancreas8.6
placenta15.3
prostate13.7
salivary gland11.2
skin14.5
small intestine26.9
spleen42.7
stomach14.2
testis40.9
thyroid gland13.6
urinary bladder17.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%215470, phenotype) Chorioretinal dystrophy, spinocerebellar ataxia, and hypogonadotropicOMIM
2(*603197, gene) Patatin-like phospholipase domain-containing protein 6; PNPLA6OMIM
3(#612020, phenotype) Spastic paraplegia 39, autosomal recessive; SPG39OMIM


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