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> Protein (NX_Q8IY92)
Protein (NX_Q8IY92)
Protein
Gene SymbolSLX4 to neXtProt (NX_Q8IY92)
DescriptionStructure-specific endonuclease subunit SLX4
Chromosome16
Location16p13.3 (3631182 ~ 3661599) to Ensembl
Sequene Features : Isoforms 2, Variants 331, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 331 9
2014-09-19protein level
2 264 9
2014-05-27protein level
2 264 9
2014-02-25protein level
2 263 9
2013-12-09protein level
2 192 9
2013-11-01protein level
2 184 9
2013-09-12protein level
2 184 9
2013-08-17protein level
2 184 9
2013-07-15protein level
2 146 9
2013-06-11protein level
2 146 9
2013-02-12protein level
2 100 13
2012-12-20protein level
2 85 13
2012-10-30protein level
2 95 13
2012-10-07protein level
2 95 7
2012-08-24protein level
2 82 7
2012-07-28protein level
2 82 7
2012-06-08protein level
2 7 7
2012-05-07protein level
2 7 7
2012-04-10protein level
2 7 7
2012-01-13protein level
2 7 7
2011-12-20protein level
2 8 7
2011-11-11protein level
2 8 6
2011-08-23protein level
2 8 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IY92-1
16 63 0 199888.0447
NX_Q8IY92-2
0 63 0 165800.0818
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2370740,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
2 EBI-2370740,EBI-355888 MSH2  
  .positive regulation of helicase activity
.negative regulation of DNA recombination
.isotype switching
  + 23 more...
.protein homodimerization activity
.guanine/thymine mispair binding
.protein kinase binding
  + 10 more...
.MutSbeta complex
.MutSalpha complex
.membrane
  + 2 more...
3 EBI-2370740,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
4 EBI-2370740,EBI-706637 TERF2  
  .negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
  + 15 more...
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
  + 2 more...
.Golgi apparatus
.cytoplasm
.nucleoplasm
  + 5 more...
5 EBI-2370740,EBI-2370881 SLX4IP  
  .N/A .N/A .N/A
6 EBI-2370740,EBI-2370770 ERCC4  
  .nucleotide-excision repair involved in interstrand cross-link repair
.nucleotide-excision repair, DNA incision
.negative regulation of telomere maintenance
  + 11 more...
.protein N-terminus binding
.protein C-terminus binding
.endodeoxyribonuclease activity
  + 3 more...
.transcription factor TFIID complex
.nucleoplasm
.nucleus
  + 4 more...
7 EBI-2370740,EBI-2370825 EME1  
  .response to intra-S DNA damage checkpoint signaling
.DNA recombination
.DNA repair
.metal ion binding
.endonuclease activity
.DNA binding
.cytoplasm
.nucleolus
.nuclear heterochromatin
.nucleus
8 EBI-2370740,EBI-2370806 MUS81  
  .response to intra-S DNA damage checkpoint signaling
.DNA recombination
.DNA repair
.DNA catabolic process, endonucleolytic
.3'-flap endonuclease activity
.metal ion binding
.DNA binding
.nucleolus
.nucleus
9 EBI-2370740,EBI-2370858 SLX1B  
  .DNA double-strand break processing involved in repair via single-strand annealing
.DNA repair
.double-strand break repair via homologous recombination
.metal ion binding
.5'-flap endonuclease activity
.crossover junction endodeoxyribonuclease activity
.Slx1-Slx4 complex
10 EBI-2370740,EBI-750109 TERF2IP  
  .positive regulation of protein acetylation
.protein localization to chromosome, telomeric region
.positive regulation of NF-kappaB transcription factor activity
  + 11 more...
.DNA binding .cytoplasm
.nucleoplasm
.nuclear envelope
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
brain8
embryonic tissue18
intestine17
kidney4
liver9
lung8
lymph22
lymph node111
mammary gland6
mouth30
muscle18
ovary9
pancreas18
placenta3
skin4
spleen18
testis18
uterus17
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor10
colorectal tumor26
gastrointestinal tumor8
germ cell tumor3
glioma37
head and neck tumor14
kidney tumor14
leukemia10
lung tumor29
lymphoma13
ovarian tumor13
pancreatic tumor38
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult6
blastocyst16
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
adrenal gland1.4
appendix3.4
bone marrow2.5
cerebral cortex2.6
colon1.6
duodenum2.3
esophagus1.4
gallbladder1.4
kidney1.3
lung1.8
lymph node4.5
ovary1.3
placenta1.5
prostate1.6
salivary gland1.1
skin1.9
small intestine2
spleen2.9
stomach2
testis9.9
thyroid gland1.1
urinary bladder1.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613278, gene) Slx4, s. cerevisiae, homolog of; SLX4OMIM
2(#613951, phenotype) Fanconi anemia, complementation group p; FANCPOMIM


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