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> Protein (NX_Q8IYA8)
Protein (NX_Q8IYA8)
Protein
Gene SymbolCCDC36 to neXtProt (NX_Q8IYA8)
DescriptionCoiled-coil domain-containing protein 36
Chromosome3
Location3p21.31 (49235861 ~ 49295537) to Ensembl
Sequene Features : Isoforms 3, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of defense response to virus by host .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
3 57 0
2014-09-19transcript level
3 48 0
2014-05-27transcript level
3 46 0
2014-02-25transcript level
3 46 0
2013-12-09transcript level
3 37 0
2013-11-01transcript level
3 36 0
2013-09-12transcript level
3 36 0
2013-08-17transcript level
3 36 0
2013-07-15transcript level
3 22 0
2013-06-11transcript level
3 22 0
2013-02-12protein level
3 9 2
2012-12-20protein level
3 9 2
2012-10-30protein level
3 7 2
2012-10-07protein level
3 7 1
2012-08-24protein level
3 7 1
2012-07-28protein level
3 7 1
2012-06-08protein level
3 9 1
2012-05-07protein level
3 7 1
2012-04-10protein level
3 7 1
2012-01-13protein level
3 2 1
2011-12-20protein level
3 2 1
2011-11-11protein level
3 2 1
2011-08-23protein level
3 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IYA8-1
0 27 0 66301.1425
NX_Q8IYA8-2
2 22 0 64224.0163
NX_Q8IYA8-3
3 7 0 23181.4705
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8638439,EBI-618295 STK25  
  .Golgi reassembly
.establishment of Golgi localization
.Golgi localization
  + 12 more...
.metal ion binding
.protein homodimerization activity
.ATP binding
  + 2 more...
.extracellular exosome
.Golgi apparatus
.cytoplasm
2 EBI-8638439,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-8638439,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
4 EBI-8638439,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
5 EBI-8638439,EBI-744771 FKBP6  
  .chaperone-mediated protein folding
.DNA methylation involved in gamete generation
.piRNA metabolic process
  + 6 more...
.Hsp90 protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.cytosol
.endoplasmic reticulum membrane
.cytoplasm
.synaptonemal complex
6 EBI-8638439,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
7 EBI-8638439,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
8 EBI-8638439,EBI-740553 GYS1  
  .small molecule metabolic process
.heart development
.glucose metabolic process
  + 2 more...
.glycogen synthase activity, transferring glucose-1-phosphate
.protein kinase binding
.glucose binding
.glycogen (starch) synthase activity
.inclusion body
.membrane
.cytosol
.cytoplasm
9 EBI-8638439,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
10 EBI-8638439,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
11 EBI-8638439,EBI-349105 DYNLL1  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of phosphorylation
  + 15 more...
.nitric-oxide synthase regulator activity
.motor activity
.ciliary tip
.mitotic spindle
.primary cilium
  + 11 more...
12 EBI-8638439,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
13 EBI-8638439,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
14 EBI-8638439,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
15 EBI-8638439,EBI-948354 TTC19  
  .mitochondrial respiratory chain complex III assembly
.cytokinesis
.N/A .midbody
.centrosome
.mitochondrial inner membrane
.mitochondrion
16 EBI-8638439,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
17 EBI-8638439,EBI-744506 FAM124A  
  .N/A .N/A .N/A
18 EBI-8638439,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
19 EBI-8638439,EBI-742371 DYNLL2  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.antigen processing and presentation of exogenous peptide antigen via MHC class II
  + 6 more...
.motor activity .ciliary tip
.primary cilium
.dynein complex
  + 7 more...
20 EBI-8638439,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
21 EBI-8638439,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
22 EBI-8638439,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
23 EBI-8638439,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
24 EBI-8638439,EBI-10311409 NGB  
  .oxygen transport
.apoptotic process
.heme binding
.iron ion binding
.oxygen transporter activity
.perikaryon
.mitochondrion
25 EBI-8638439,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
26 EBI-8638439,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
27 EBI-8638439,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
28 EBI-8638439,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
29 EBI-8638439,EBI-2511991 USP20  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 4 more...
.zinc ion binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.G-protein coupled receptor binding
.perinuclear region of cytoplasm
.centrosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
esophagus49
kidney4
larynx85
skin4
testis52
uterus4
Health State
TissuesTPM*
normal2
esophageal tumor57
head and neck tumor14
skin tumor7
Developmental Stage
TissuesTPM*
adult2
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.6
ovary2.5
testis34.3
thyroid gland1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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2014-2019 (C) Yonsei Proteome Research Center