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> Protein (NX_Q8IYE0)
Protein (NX_Q8IYE0)
Protein
Gene SymbolCCDC146 to neXtProt (NX_Q8IYE0)
DescriptionCoiled-coil domain-containing protein 146
Chromosome7
Location7q11.23 (76751751 ~ 76958850) to Ensembl
Sequene Features : Isoforms 2, Variants 118, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .centriole
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
2 118 0
2014-09-19transcript level
2 90 0
2014-05-27transcript level
2 90 0
2014-02-25transcript level
2 89 0
2013-12-09transcript level
2 70 0
2013-11-01transcript level
2 68 0
2013-09-12transcript level
2 68 0
2013-08-17transcript level
2 68 0
2013-07-15transcript level
2 49 0
2013-06-11transcript level
2 49 0
2013-02-12transcript level
2 28 0
2012-12-20transcript level
2 27 0
2012-10-30transcript level
2 29 0
2012-10-07transcript level
2 29 0
2012-08-24transcript level
2 28 0
2012-07-28transcript level
2 28 0
2012-06-08transcript level
2 24 0
2012-05-07transcript level
2 24 0
2012-04-10transcript level
2 24 0
2012-01-13transcript level
2 12 0
2011-12-20transcript level
2 12 0
2011-11-11transcript level
2 12 0
2011-08-23transcript level
2 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IYE0-1
11 29 0 112735.5869
NX_Q8IYE0-2
0 29 0 78981.1386
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10247802,EBI-744408 RNF40  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
2 EBI-10247802,EBI-371669 GMNN  
  .negative regulation of transcription, DNA-templated
.negative regulation of cell cycle
.organ morphogenesis
  + 3 more...
.histone deacetylase binding
.transcription corepressor activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-10247802,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
4 EBI-10247802,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
5 EBI-10247802,EBI-297888 KRT18  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
6 EBI-10247802,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
7 EBI-10247802,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
8 EBI-10247802,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
9 EBI-10247802,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
10 EBI-10247802,EBI-10178634 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
11 EBI-10247802,EBI-357669 PSMC6  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.proteasome-activating ATPase activity
.protein binding, bridging
.TBP-class protein binding
  + 2 more...
.extracellular exosome
.cytosolic proteasome complex
.nuclear proteasome complex
  + 7 more...
12 EBI-10247802,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-10247802,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
14 EBI-10247802,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
15 EBI-10247802,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-10247802,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
17 EBI-10247802,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
18 EBI-10247802,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
19 EBI-10247802,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
20 EBI-10247802,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
21 EBI-10247802,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
22 EBI-10247802,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
23 EBI-10247802,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
24 EBI-10247802,EBI-743488 CEP170P1  
  .N/A .identical protein binding .N/A
25 EBI-10247802,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
26 EBI-10247802,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
27 EBI-10247802,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
28 EBI-10247802,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
29 EBI-10247802,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
30 EBI-10247802,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain6
connective tissue13
eye9
heart22
intestine8
kidney37
liver9
lung29
mammary gland6
mouth15
muscle47
nerve64
ovary39
pharynx49
placenta7
prostate5
stomach52
testis48
trachea57
uterus30
vascular77
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor10
chondrosarcoma24
gastrointestinal tumor8
germ cell tumor7
head and neck tumor7
kidney tumor58
liver tumor10
ovarian tumor52
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult18
fetus34
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.7
adrenal gland2.6
appendix4.3
bone marrow2.8
cerebral cortex3.1
colon4.5
duodenum4
esophagus7.1
gallbladder13.4
heart muscle7.2
kidney9.2
liver5.7
lung9.9
lymph node6.3
ovary5.7
pancreas1.8
placenta3.1
prostate5.6
salivary gland3.8
skin21.6
small intestine5.3
spleen7.6
stomach4.2
testis24.7
thyroid gland22.7
urinary bladder4.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungHigh
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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