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> Protein (NX_Q8IYI6)
Protein (NX_Q8IYI6)
Protein
Gene SymbolEXOC8 to neXtProt (NX_Q8IYI6)
DescriptionExocyst complex component 8
Chromosome1
Location1q42.2 (231468480 ~ 231473598) to Ensembl
Sequene Features : Isoforms 1, Variants 65, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 65 4
2014-09-19protein level
1 49 4
2014-05-27protein level
1 49 4
2014-02-25protein level
1 49 4
2013-12-09protein level
1 39 4
2013-11-01protein level
1 37 3
2013-09-12protein level
1 37 3
2013-08-17protein level
1 37 3
2013-07-15protein level
1 22 2
2013-06-11protein level
1 22 2
2013-02-12protein level
1 8 2
2012-12-20protein level
1 8 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 7 2
2012-07-28protein level
1 7 2
2012-06-08protein level
1 7 2
2012-05-07protein level
1 7 2
2012-04-10protein level
1 7 2
2012-01-13protein level
1 5 2
2011-12-20protein level
1 5 2
2011-11-11protein level
1 5 2
2011-08-23protein level
1 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IYI6-1
38 0 0 81747.2068
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742102,EBI-6160405 WASH1  
  .retrograde transport, endosome to plasma membrane
.retrograde transport, endosome to Golgi
.Arp2/3 complex-mediated actin nucleation
  + 6 more...
.alpha-tubulin binding
.ubiquitin protein ligase binding
.invadopodium
.WASH complex
.recycling endosome membrane
  + 7 more...
2 EBI-742102,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
3 EBI-742102,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-742102,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
5 EBI-742102,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
6 EBI-742102,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
7 EBI-742102,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood8
brain4
connective tissue6
embryonic tissue9
eye4
heart11
intestine4
kidney9
lymph node44
mouth15
pancreas23
parathyroid48
placenta14
prostate5
skin9
testis9
thymus12
thyroid42
uterus17
Health State
TissuesTPM*
normal10
chondrosarcoma12
germ cell tumor3
head and neck tumor14
leukemia10
non-neoplasia10
pancreatic tumor19
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult7
fetus14
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.3
adrenal gland5.8
appendix8.4
bone marrow10.6
cerebral cortex7.1
colon5.3
duodenum5.5
esophagus6
gallbladder5.6
heart muscle4.2
kidney5.5
liver3.2
lung6
lymph node9.2
ovary7
pancreas3
placenta6.8
prostate4.9
salivary gland4.1
skin5.2
small intestine6
spleen7.7
stomach6.3
testis4.9
thyroid gland8.6
urinary bladder6.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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