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> Protein (NX_Q8IYI8)
Protein (NX_Q8IYI8)
Protein
Gene SymbolZNF440 to neXtProt (NX_Q8IYI8)
DescriptionZinc finger protein 440
Chromosome19
Location19p13.2 (11925099 ~ 11946016) to Ensembl
Sequene Features : Isoforms 1, Variants 97, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 97 0
2014-09-19protein level
1 76 0
2014-05-27transcript level
1 76 0
2014-02-25transcript level
1 76 0
2013-12-09transcript level
1 50 0
2013-11-01transcript level
1 49 0
2013-09-12transcript level
1 49 0
2013-08-17transcript level
1 49 0
2013-07-15transcript level
1 36 0
2013-06-11transcript level
1 36 0
2013-02-12transcript level
1 17 0
2012-12-20transcript level
1 18 0
2012-10-30transcript level
1 25 0
2012-10-07transcript level
1 25 0
2012-08-24transcript level
1 25 0
2012-07-28transcript level
1 25 0
2012-06-08transcript level
1 27 0
2012-05-07transcript level
1 22 0
2012-04-10transcript level
1 22 0
2012-01-13transcript level
1 10 0
2011-12-20transcript level
1 10 0
2011-11-11transcript level
1 10 0
2011-08-23transcript level
1 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IYI8-1
18 0 6 69060.5574
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-726439,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
2 EBI-726439,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
3 EBI-726439,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
4 EBI-726439,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
5 EBI-726439,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
6 EBI-726439,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone13
brain12
connective tissue13
embryonic tissue23
eye4
heart22
intestine8
kidney18
liver14
lung5
mammary gland6
mouth45
muscle9
pancreas4
placenta10
prostate10
skin9
spleen18
stomach10
testis6
thymus12
trachea38
uterus12
Health State
TissuesTPM*
normal10
chondrosarcoma24
gastrointestinal tumor16
germ cell tumor3
head and neck tumor22
liver tumor20
pancreatic tumor9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult7
embryoid body28
blastocyst32
fetus10
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.9
adrenal gland2.3
appendix3.9
bone marrow4.4
cerebral cortex3.4
colon11.4
duodenum5
esophagus9.4
gallbladder4.3
heart muscle1.8
kidney4.8
liver1.9
lung7.1
lymph node4.4
ovary3.3
pancreas2.2
placenta9
prostate5.3
salivary gland2.5
skin13.6
small intestine7.2
spleen3.8
stomach6.4
testis6
thyroid gland4.5
urinary bladder12.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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