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> Protein (NX_Q8IYX8)
Protein (NX_Q8IYX8)
Protein
Gene SymbolCEP57L1 to neXtProt (NX_Q8IYX8)
DescriptionCentrosomal protein CEP57L1
Chromosome6
Location6q21 (109416313 ~ 109485135) to Ensembl
Sequene Features : Isoforms 2, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 46 2
2014-09-19protein level
2 36 2
2014-05-27protein level
1 36 2
2014-02-25protein level
1 35 2
2013-12-09protein level
1 29 2
2013-11-01protein level
1 29 1
2013-09-12protein level
1 29 1
2013-08-17protein level
1 29 1
2013-07-15protein level
1 22 1
2013-06-11protein level
1 22 1
2013-02-12transcript level
1 13 0
2012-12-20transcript level
1 13 0
2012-10-30transcript level
1 15 0
2012-10-07transcript level
1 15 0
2012-08-24transcript level
1 15 0
2012-07-28transcript level
1 14 0
2012-06-08transcript level
1 14 0
2012-05-07transcript level
1 14 0
2012-04-10transcript level
1 14 0
2012-01-13transcript level
1 7 0
2011-12-20transcript level
1 7 0
2011-11-11transcript level
1 7 0
2011-08-23transcript level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IYX8-1
3 16 0 53614.3678
NX_Q8IYX8-2
0 16 0 45599.4357
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10181988,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-10181988,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
3 EBI-10181988,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
4 EBI-10181988,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
5 EBI-10181988,EBI-448202 GADD45G  
  .positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
6 EBI-10181988,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
7 EBI-10181988,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
8 EBI-10181988,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
9 EBI-10181988,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
10 EBI-10181988,EBI-740978 MAGEA1  
  .negative regulation of Notch signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .plasma membrane
.cytoplasm
.nucleus
11 EBI-1104570,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
12 EBI-10181988,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
13 EBI-10181988,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
14 EBI-10181988,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
15 EBI-1104570,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
16 EBI-10181988,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
17 EBI-10181988,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
18 EBI-10181988,EBI-742350 TCEB3  
  .positive regulation of viral transcription
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.viral process
  + 4 more...
.DNA binding .elongin complex
.integral component of membrane
.cytoplasm
  + 3 more...
19 EBI-10181988,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
20 EBI-10181988,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
21 EBI-10181988,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
22 EBI-10181988,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
23 EBI-10181988,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
24 EBI-10181988,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
25 EBI-10181988,EBI-10244848 SNAP47  
  .long-term synaptic potentiation
.synaptic vesicle fusion to presynaptic membrane
.synaptic vesicle priming
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.neuronal cell body
.SNARE complex
  + 3 more...
26 EBI-1104570,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
27 EBI-10181988,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
28 EBI-10181988,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
29 EBI-10181988,EBI-742102 EXOC8  
  .membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
30 EBI-10181988,EBI-749051 C6orf165  
  .N/A .N/A .N/A
31 EBI-1104570,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
32 EBI-10181988,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
33 EBI-10181988,EBI-750003 HDDC3  
  .N/A .metal ion binding
.guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
.N/A
34 EBI-10181988,EBI-359964 TAB3  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 19 more...
.zinc ion binding .extracellular exosome
.endosome membrane
.plasma membrane
  + 3 more...
35 EBI-10181988,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
36 EBI-10181988,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
37 EBI-10181988,EBI-742259 LMO3  
  .positive regulation of glucocorticoid receptor signaling pathway
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of fat cell differentiation
  + 3 more...
.zinc ion binding .cytoplasm
38 EBI-10181988,EBI-740680 DYDC1  
  .N/A .N/A .N/A
39 EBI-10181988,EBI-6164177 GOLGA1  
  .protein targeting to Golgi .N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.Golgi cisterna membrane
  + 2 more...
40 EBI-1104570,EBI-1760638 SNAPC3  
  .gene expression
.snRNA transcription
.transcription from RNA polymerase III promoter
  + 2 more...
.DNA binding .nucleolus
.nucleoplasm
.nucleus
41 EBI-10181988,EBI-726510 LENG1  
  .N/A .N/A .N/A
42 EBI-10181988,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
43 EBI-1104570,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
44 EBI-10181988,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
45 EBI-10181988,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
46 EBI-1104570,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
47 EBI-10181988,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
48 EBI-10181988,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
49 EBI-10181988,EBI-743591 KATNAL1  
  .microtubule severing
.cytoplasmic microtubule organization
.metabolic process
.spermatogenesis
.microtubule-severing ATPase activity
.ATP binding
.microtubule
.cytoplasm
.nucleus
50 EBI-10181988,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
51 EBI-10181988,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
52 EBI-10181988,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
53 EBI-10181988,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
54 EBI-10181988,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
55 EBI-10181988,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
56 EBI-10181988,EBI-949319 KLC4  
  .N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
57 EBI-1104570,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
58 EBI-10181988,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
59 EBI-10181988,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
60 EBI-10181988,EBI-747601 TRAPPC2L  
  .ER to Golgi vesicle-mediated transport .N/A .perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
bladder66
blood81
bone marrow41
brain10
cervix20
connective tissue6
embryonic tissue14
eye9
heart11
kidney4
liver14
lung8
lymph45
lymph node44
mammary gland19
mouth30
pancreas14
parathyroid145
placenta14
prostate5
skin9
testis27
trachea19
uterus17
Health State
TissuesTPM*
normal12
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
gastrointestinal tumor25
germ cell tumor3
glioma9
head and neck tumor7
leukemia74
lung tumor9
lymphoma27
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult14
embryoid body28
fetus10
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland4.7
appendix4.4
bone marrow3.4
cerebral cortex3.9
colon4.3
duodenum4.5
esophagus3.5
gallbladder5.3
heart muscle3.6
kidney4
liver3.6
lung4
lymph node4.3
ovary3.6
pancreas2.1
placenta4.4
prostate4.1
salivary gland2.4
skin3.4
small intestine4
spleen4
stomach4.1
testis12.1
thyroid gland4.9
urinary bladder5.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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