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> Protein (NX_Q8IZD2)
Protein (NX_Q8IZD2)
Protein
Gene SymbolKMT2E to neXtProt (NX_Q8IZD2)
DescriptionHistone-lysine N-methyltransferase 2E
Chromosome7
Location7q22.3 (104654626 ~ 104754808) to Ensembl
Sequene Features : Isoforms 8, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to retinoic acid
.histone H3-K4 methylation
.retinoic acid receptor signaling pathway
  + 9 more...
.histone methyltransferase activity (H3-K4 specific)
.enzyme binding
.zinc ion binding
.transcription coactivator activity
.MLL5-L complex
.intercellular bridge
.intracellular membrane-bounded organelle
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 58 4
2014-09-19protein level
8 165 4
2014-05-27protein level
8 164 5
2014-02-25protein level
7 164 5
2013-12-09protein level
7 123 5
2013-11-01protein level
7 117 5
2013-09-12protein level
7 117 5
2013-08-17protein level
7 117 5
2013-07-15protein level
7 73 5
2013-06-11protein level
7 73 5
2013-02-12protein level
7 37 12
2012-12-20protein level
7 37 12
2012-10-30protein level
7 44 12
2012-10-07protein level
7 44 2
2012-08-24protein level
7 40 2
2012-07-28protein level
7 41 2
2012-06-08protein level
7 22 2
2012-05-07protein level
7 22 2
2012-04-10protein level
7 22 2
2012-01-13protein level
7 22 2
2011-12-20protein level
7 22 2
2011-11-11protein level
7 22 2
2011-08-23protein level
7 22 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IZD2-1
0 64 1 204837.4304
NX_Q8IZD2-2
0 61 1 195552.8419
NX_Q8IZD2-3
1 21 1 68882.6357
NX_Q8IZD2-4
1 32 1 98733.0263
NX_Q8IZD2-5
6 61 1 185685.8015
NX_Q8IZD2-6
8 59 1 180666.2333
NX_Q8IZD2-7
1 62 1 200510.469
NX_Q8IZD2-8
1 49 1 131653.9191
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2689959,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder66
blood89
bone97
bone marrow205
brain42
cervix41
connective tissue13
ear372
embryonic tissue65
esophagus49
eye90
heart33
intestine99
kidney80
larynx42
liver73
lung83
lymph22
lymph node77
mammary gland211
mouth151
muscle37
ovary88
pancreas117
pharynx73
placenta14
prostate73
salivary gland49
skin61
spleen74
stomach62
testis43
thymus87
thyroid85
trachea19
umbilical cord72
uterus51
vascular58
Health State
TissuesTPM*
normal74
bladder carcinoma56
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma36
colorectal tumor142
esophageal tumor57
gastrointestinal tumor33
germ cell tumor75
glioma102
head and neck tumor104
kidney tumor87
leukemia169
liver tumor72
lung tumor19
lymphoma13
non-neoplasia31
ovarian tumor78
pancreatic tumor38
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma21
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult82
embryoid body100
blastocyst32
neonate32
fetus77
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19
adrenal gland16.6
appendix30.1
bone marrow45.2
cerebral cortex24.6
colon28.1
duodenum21.1
esophagus23.4
gallbladder27.2
heart muscle16.5
kidney19.9
liver10.9
lung27.3
lymph node31.4
ovary42.8
pancreas11.4
placenta23.8
prostate23.4
salivary gland19.1
skin25.1
small intestine21.3
spleen31.2
stomach26.8
testis22.6
thyroid gland28.9
urinary bladder32.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608444, gene) Myeloid/lymphoid or mixed-lineage leukemia 5; MLL5OMIM


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