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> Protein (NX_Q8IZE3)
Protein (NX_Q8IZE3)
Protein
Gene SymbolSCYL3 to neXtProt (NX_Q8IZE3)
DescriptionProtein-associating with the carboxyl-terminal domain of ezrin
Chromosome1
Location1q24.2 (169818772 ~ 169863408) to Ensembl
Sequene Features : Isoforms 2, Variants 92, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell migration
.protein phosphorylation
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.lamellipodium
.Golgi apparatus
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 92 3
2014-09-19protein level
2 70 3
2014-05-27protein level
2 70 4
2014-02-25protein level
2 68 4
2013-12-09protein level
2 53 4
2013-11-01protein level
2 52 3
2013-09-12protein level
2 52 4
2013-08-17protein level
2 52 4
2013-07-15protein level
2 37 4
2013-06-11protein level
2 37 4
2013-02-12protein level
2 23 5
2012-12-20protein level
2 23 5
2012-10-30protein level
2 30 5
2012-10-07protein level
2 30 3
2012-08-24protein level
2 23 3
2012-07-28protein level
2 23 3
2012-06-08protein level
2 25 3
2012-05-07protein level
2 25 3
2012-04-10protein level
2 25 3
2012-01-13protein level
2 12 3
2011-12-20protein level
2 12 3
2011-11-11protein level
2 12 2
2011-08-23protein level
2 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IZE3-1
3 31 0 82804.8749
NX_Q8IZE3-2
1 31 0 76681.9337
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1380680,EBI-1056902 EZR  
  .establishment of endothelial barrier
.actin filament bundle assembly
.positive regulation of protein secretion
  + 13 more...
.actin filament binding
.cell adhesion molecule binding
.poly(A) RNA binding
.cytoplasmic side of apical plasma membrane
.Schwann cell microvillus
.astrocyte projection
  + 30 more...
2 EBI-1380680,EBI-8474075 LHX8  
  .odontogenesis of dentin-containing tooth
.forebrain neuron development
.female gonad development
  + 3 more...
.sequence-specific DNA binding
.zinc ion binding
.female germ cell nucleus
3 EBI-1380680,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
4 EBI-1380680,EBI-3464833 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood24
bone55
bone marrow41
brain25
cervix103
connective tissue20
ear62
embryonic tissue9
esophagus99
eye14
heart33
intestine21
kidney23
liver34
lung5
lymph node22
mammary gland19
mouth45
muscle9
nerve64
ovary19
parathyroid48
pharynx49
placenta38
prostate21
skin14
spleen18
stomach10
testis18
thymus12
tonsil58
trachea57
uterus25
vascular19
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma36
colorectal tumor26
esophageal tumor115
gastrointestinal tumor16
germ cell tumor53
glioma9
head and neck tumor22
kidney tumor29
leukemia10
liver tumor20
lymphoma13
non-neoplasia20
ovarian tumor26
prostate cancer28
skin tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult28
embryoid body14
fetus25
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.8
adrenal gland6.2
appendix7.7
bone marrow1.9
cerebral cortex4.4
colon8.2
duodenum7.8
esophagus7.3
gallbladder9.2
heart muscle4.4
kidney6.7
liver5
lung5.7
lymph node10.3
ovary8.4
pancreas4.1
placenta8.7
prostate8.3
salivary gland6.4
skin6.3
small intestine6.5
spleen7.2
stomach7.5
testis7.7
thyroid gland8.2
urinary bladder9.9
Tissues
TissuesExpression level
appendixLow
bone marrowLow
breastMedium
cerebellumLow
cerebral cortexMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeMedium
gallbladderLow
heart muscleMedium
hippocampusLow
kidneyMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608192, gene) Protein associated with the c-terminal domain of ezrinOMIM


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