Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q8IZQ1)
Protein (NX_Q8IZQ1)
Protein
Gene SymbolWDFY3 to neXtProt (NX_Q8IZQ1)
DescriptionWD repeat and FYVE domain-containing protein 3
Chromosome4
Location4q21.23 (85590704 ~ 85887544) to Ensembl
Sequene Features : Isoforms 2, Variants 373, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 373 4
2014-09-19protein level
2 272 4
2014-05-27protein level
2 272 4
2014-02-25protein level
2 267 4
2013-12-09protein level
2 226 4
2013-11-01protein level
2 217 3
2013-09-12protein level
2 217 4
2013-08-17protein level
2 217 4
2013-07-15protein level
2 135 4
2013-06-11protein level
2 135 4
2013-02-12protein level
2 55 22
2012-12-20protein level
2 51 22
2012-10-30protein level
2 68 22
2012-10-07protein level
2 68 11
2012-08-24protein level
2 37 11
2012-07-28protein level
2 37 11
2012-06-08protein level
2 40 11
2012-05-07protein level
2 39 11
2012-04-10protein level
2 39 11
2012-01-13protein level
2 16 11
2011-12-20protein level
2 16 11
2011-11-11protein level
2 16 11
2011-08-23protein level
2 16 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8IZQ1-1
2 153 0 395005.3062
NX_Q8IZQ1-2
1 153 0 393115.3744
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1569256,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-1569256,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-10264625,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
4 EBI-10264625,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
5 EBI-1569256,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
6 EBI-1569256,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
7 EBI-1569256,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
8 EBI-1569256,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
9 EBI-1569256,EBI-1047414 ATG5  
  .negative regulation of histone H4-K16 acetylation
.regulation of reactive oxygen species metabolic process
.regulation of cilium assembly
  + 23 more...
.N/A .ER-mitochondrion membrane contact site
.Atg12-Atg5-Atg16 complex
.pre-autophagosomal structure membrane
  + 4 more...
10 EBI-10264625,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood16
bone13
bone marrow20
brain44
connective tissue40
embryonic tissue42
eye28
intestine25
kidney118
larynx213
liver19
lung50
lymph node11
mammary gland52
muscle18
nerve128
ovary68
pancreas60
parathyroid48
pharynx49
placenta70
prostate26
skin23
stomach41
testis18
thyroid128
trachea19
uterus47
vascular58
Health State
TissuesTPM*
normal47
adrenal tumor79
breast (mammary gland) tumor64
chondrosarcoma48
colorectal tumor44
gastrointestinal tumor50
germ cell tumor45
glioma65
head and neck tumor89
kidney tumor14
leukemia21
liver tumor20
lung tumor29
non-neoplasia51
ovarian tumor78
pancreatic tumor28
prostate cancer38
retinoblastoma21
Developmental Stage
TissuesTPM*
adult55
embryoid body42
blastocyst81
fetus43
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
adrenal gland11.8
appendix11.6
bone marrow13.5
cerebral cortex19.2
colon10
duodenum3.8
esophagus14.5
gallbladder18.3
heart muscle7.3
kidney27.2
liver4.8
lung10
lymph node4.2
ovary22.2
pancreas6.2
placenta17.3
prostate10.8
salivary gland7.5
skin14.3
small intestine6
spleen9.8
stomach8.1
testis13
thyroid gland19.5
urinary bladder18.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center