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> Protein (NX_Q8N0S2)
Protein (NX_Q8N0S2)
Protein
Gene SymbolSYCE1 to neXtProt (NX_Q8N0S2)
DescriptionSynaptonemal complex central element protein 1
Chromosome10
Location10q26.3 (135367404 ~ 135382876) to Ensembl
Sequene Features : Isoforms 3, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.synaptonemal complex assembly
.N/A .central element
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 67 0
2014-09-19protein level
3 54 0
2014-05-27transcript level
3 54 0
2014-02-25transcript level
3 54 0
2013-12-09transcript level
3 44 0
2013-11-01transcript level
3 36 0
2013-09-12transcript level
3 36 0
2013-08-17protein level
3 36 0
2013-07-15protein level
3 28 0
2013-06-11protein level
3 28 0
2013-02-12protein level
3 18 0
2012-12-20protein level
3 16 0
2012-10-30protein level
3 22 0
2012-10-07protein level
3 22 0
2012-08-24transcript level
3 20 0
2012-07-28transcript level
3 20 0
2012-06-08transcript level
3 21 0
2012-05-07transcript level
3 21 0
2012-04-10transcript level
3 21 0
2012-01-13transcript level
3 12 0
2011-12-20transcript level
3 12 0
2011-11-11transcript level
3 12 0
2011-08-23transcript level
3 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N0S2-1
5 11 0 39674.3049
NX_Q8N0S2-2
0 12 0 32580.7352
NX_Q8N0S2-3
0 8 0 21887.9725
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6872807,EBI-741648 CYTH3  
  .establishment of epithelial cell polarity
.Golgi vesicle transport
.positive regulation of cell adhesion
  + 2 more...
.phosphatidylinositol-3,4,5-trisphosphate binding
.ARF guanyl-nucleotide exchange factor activity
.extrinsic component of cytoplasmic side of plasma membrane
.plasma membrane
.cytosol
.ruffle
2 EBI-6872807,EBI-355607 TPM3  
  .muscle filament sliding
.muscle contraction
.movement of cell or subcellular component
.N/A .extracellular exosome
.muscle thin filament tropomyosin
.cytoskeleton
  + 2 more...
3 EBI-6872807,EBI-351158 TPM1  
  .cardiac muscle contraction
.ventricular cardiac muscle tissue morphogenesis
.positive regulation of stress fiber assembly
  + 15 more...
.structural constituent of muscle
.cytoskeletal protein binding
.structural constituent of cytoskeleton
.actin binding
.ruffle membrane
.bleb
.filamentous actin
  + 5 more...
4 EBI-6872807,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
5 EBI-6872807,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
6 EBI-6872807,EBI-10229433 BFSP2  
  .lens fiber cell development
.response to stimulus
.cell maturation
  + 2 more...
.structural constituent of eye lens
.structural constituent of cytoskeleton
.plasma membrane
.intermediate filament
.cytoplasm
7 EBI-6872807,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
8 EBI-6872807,EBI-2210673 SSX2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
9 EBI-6872807,EBI-10240074 EDRF1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
10 EBI-6872807,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
11 EBI-6872807,EBI-8484990 STX19  
  .vesicle docking
.synaptic vesicle fusion to presynaptic membrane
.intracellular protein transport
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 2 more...
12 EBI-6872807,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
13 EBI-6872807,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
14 EBI-6872807,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
15 EBI-6872807,EBI-741854 SKA1  
  .cell division
.regulation of microtubule polymerization or depolymerization
.small GTPase mediated signal transduction
  + 3 more...
.microtubule binding .microtubule cytoskeleton
.spindle microtubule
.cytosol
.condensed chromosome outer kinetochore
16 EBI-6872807,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
17 EBI-6872807,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
18 EBI-6872807,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
19 EBI-6872807,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
20 EBI-6872807,EBI-739784 CINP  
  .cell division
.cell cycle
.DNA repair
.DNA replication
.N/A .nucleus
21 EBI-6872807,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
22 EBI-6872807,EBI-2340624 RBCK1  
  .positive regulation of extrinsic apoptotic signaling pathway
.protein linear polyubiquitination
.negative regulation of necroptotic process
  + 8 more...
.ubiquitin binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.LUBAC complex
23 EBI-6872807,EBI-713401 HMG20B  
  .positive regulation of neuron differentiation
.skeletal muscle cell differentiation
.negative regulation of protein sumoylation
  + 6 more...
.chromatin binding
.DNA binding
.chromosome
.nucleoplasm
24 EBI-6872807,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
25 EBI-6872807,EBI-746704 HOOK1  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 4 more...
.identical protein binding .FHF complex
.microtubule
26 EBI-6872807,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
27 EBI-6872807,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
brain7
lung2
placenta17
testis133
thymus12
trachea19
Health State
TissuesTPM*
normal11
adrenal tumor79
lymphoma27
Developmental Stage
TissuesTPM*
adult3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.6
adrenal gland1.5
cerebral cortex7.4
gallbladder1.6
liver4.6
ovary1.1
placenta8.9
prostate2.7
testis59.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611486, gene) Synaptonemal complex central element protein 1; SYCE1OMIM


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