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> Protein (NX_Q8N1B4)
Protein (NX_Q8N1B4)
Protein
Gene SymbolVPS52 to neXtProt (NX_Q8N1B4)
DescriptionVacuolar protein sorting-associated protein 52 homolog
Chromosome6
Location6p21.32 (33218049 ~ 33239824) to Ensembl
Sequene Features : Isoforms 2, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 56 2
2014-09-19protein level
1 40 2
2014-05-27protein level
1 40 2
2014-02-25protein level
1 11 2
2013-12-09protein level
1 8 2
2013-11-01protein level
1 8 2
2013-09-12protein level
1 8 1
2013-08-17protein level
1 8 1
2013-07-15protein level
1 8 0
2013-06-11protein level
1 8 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 8 0
2012-07-28protein level
1 8 0
2012-06-08protein level
1 12 0
2012-05-07protein level
1 12 0
2012-04-10protein level
1 10 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N1B4-1
4 31 0 82169.3825
NX_Q8N1B4-2
0 31 0 68452.5761
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2799833,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
2 EBI-2799833,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
3 EBI-2799833,EBI-355607 TPM3  
  .muscle filament sliding
.muscle contraction
.movement of cell or subcellular component
.N/A .extracellular exosome
.muscle thin filament tropomyosin
.cytoskeleton
  + 2 more...
4 EBI-2799833,EBI-722284 RAB4A  
  .membrane organization
.Rab protein signal transduction
.regulation of endocytosis
  + 3 more...
.GDP binding
.protein transporter activity
.GTP binding
.GTPase activity
.extracellular exosome
.perinuclear region of cytoplasm
.insulin-responsive compartment
  + 3 more...
5 EBI-2799833,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
6 EBI-2799833,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
7 EBI-2799833,EBI-356811 NOP2  
  .positive regulation of cell proliferation
.rRNA processing
.poly(A) RNA binding
.S-adenosylmethionine-dependent methyltransferase activity
.nucleolus
8 EBI-2799833,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
9 EBI-2799833,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
10 EBI-2799833,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
11 EBI-2799833,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
12 EBI-2799833,EBI-751647 WTAP  
  .mRNA methylation
.RNA splicing
.cell cycle
  + 2 more...
.N/A .MIS complex
.nuclear membrane
.nuclear speck
  + 2 more...
13 EBI-2799833,EBI-352889 NFKBIB  
  .cellular response to lipopolysaccharide
.positive regulation of NF-kappaB transcription factor activity
.innate immune response
  + 15 more...
.signal transducer activity
.transcription coactivator activity
.cytosol
.nucleus
14 EBI-2799833,EBI-10188326 KIAA1217  
  .embryonic skeletal system development .N/A .cytoplasm
15 EBI-2799833,EBI-8994397 TSTD2  
  .N/A .N/A .N/A
16 EBI-2799833,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
17 EBI-2799833,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
18 EBI-2799833,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
19 EBI-2799833,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
20 EBI-2799833,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
21 EBI-2799833,EBI-1053295 METTL13  
  .N/A .methyltransferase activity .N/A
22 EBI-2799833,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
23 EBI-2799833,EBI-6164177 GOLGA1  
  .protein targeting to Golgi .N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.Golgi cisterna membrane
  + 2 more...
24 EBI-2799833,EBI-2371750 GFM2  
  .mitochondrial translational termination
.ribosome disassembly
.mitochondrial translation
.organelle organization
.GTP binding
.GTPase activity
.mitochondrial matrix
25 EBI-2799833,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
26 EBI-2799833,EBI-1790529 THAP11  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.intercellular bridge
.cytoplasm
.nucleoplasm
27 EBI-2799833,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
28 EBI-2799833,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
29 EBI-2799833,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
30 EBI-2799833,EBI-2130266 RNF41  
  .positive regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.regulation of establishment of cell polarity
  + 12 more...
.ubiquitin protein ligase activity
.protein tag
.Ral GTPase binding
  + 3 more...
.cytosol
31 EBI-2799833,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
32 EBI-2799833,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
33 EBI-2799833,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
34 EBI-2799833,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
35 EBI-2799833,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
36 EBI-2799833,EBI-2684998 ATP6V1D  
  .phagosome maturation
.protein localization to cilium
.transmembrane transport
  + 7 more...
.ATPase activity, coupled to transmembrane movement of substances .extracellular exosome
.proton-transporting V-type ATPase complex
.membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder100
blood81
bone55
bone marrow41
brain140
cervix82
connective tissue73
embryonic tissue51
eye71
heart22
intestine81
kidney118
larynx42
liver19
lung80
lymph22
lymph node33
mammary gland138
mouth302
muscle18
ovary59
pancreas65
pharynx24
pituitary gland60
placenta109
prostate52
salivary gland98
skin227
spleen112
stomach31
testis153
thymus552
thyroid128
trachea193
umbilical cord145
uterus124
vascular19
Health State
TissuesTPM*
normal91
breast (mammary gland) tumor161
cervical tumor28
chondrosarcoma84
colorectal tumor88
gastrointestinal tumor75
germ cell tumor75
glioma27
head and neck tumor209
kidney tumor188
leukemia74
liver tumor20
lung tumor126
lymphoma69
non-neoplasia103
ovarian tumor52
pancreatic tumor104
primitive neuroectodermal tumor of the CNS118
prostate cancer48
retinoblastoma21
skin tumor279
soft tissue/muscle tissue tumor39
uterine tumor88
Developmental Stage
TissuesTPM*
adult80
embryoid body57
blastocyst65
neonate225
fetus86
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.9
adrenal gland36.8
appendix35.4
bone marrow24.1
cerebral cortex33.7
colon30.5
duodenum36.5
esophagus36.4
gallbladder33.7
heart muscle26.8
kidney29.1
liver16
lung37.1
lymph node45
ovary40.5
pancreas18.7
placenta30.1
prostate36.3
salivary gland31.7
skin61.2
small intestine34.8
spleen46
stomach35.3
testis38.6
thyroid gland47
urinary bladder30.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603443, gene) Suppressor of actin mutations 2, s. cerevisiae, homolog-like; SACM2LOMIM


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