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> Protein (NX_Q8N205)
Protein (NX_Q8N205)
Protein
Gene SymbolSYNE4 to neXtProt (NX_Q8N205)
DescriptionNesprin-4
Chromosome19
Location19q13.12 (36494209 ~ 36499695) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 0
2014-09-19protein level
2 54 0
2014-05-27protein level
2 54 0
2014-02-25protein level
2 30 0
2013-12-09protein level
2 8 0
2013-11-01protein level
2 8 0
2013-09-12protein level
2 8 0
2013-08-17protein level
2 8 0
2013-07-15transcript level
2 8 0
2013-06-11transcript level
2 8 0
2013-02-12transcript level
2 8 0
2012-12-20transcript level
2 4 0
2012-10-30transcript level
2 12 0
2012-10-07transcript level
2 12 0
2012-08-24transcript level
2 12 0
2012-07-28transcript level
2 12 0
2012-06-08transcript level
2 12 0
2012-05-07transcript level
2 12 0
2012-04-10transcript level
2 12 0
2012-01-13transcript level
2 7 0
2011-12-20transcript level
2 7 0
2011-11-11transcript level
2 9 0
2011-08-23transcript level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N205-1
5 12 0 43484.9321
NX_Q8N205-2
1 12 0 30955.3072
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7131783,EBI-10180786 SLN  
  .regulation of calcium-transporting ATPase activity
.positive regulation of protein depolymerization
.negative regulation of calcium ion binding
  + 8 more...
.ATPase binding
.enzyme inhibitor activity
.sarcoplasmic reticulum membrane
.sarcoplasmic reticulum
.integral component of membrane
2 EBI-7131783,EBI-3906484 ECE2  
  .peptide hormone processing
.cardioblast differentiation
.heart development
  + 2 more...
.metal ion binding
.methyltransferase activity
.metalloendopeptidase activity
.cytoplasmic vesicle membrane
.integral component of membrane
.Golgi membrane
3 EBI-7131783,EBI-10187968 ENTPD3  
  .nucleoside triphosphate catabolic process
.nucleoside diphosphate catabolic process
.nucleoside-triphosphatase activity
.nucleoside-diphosphatase activity
.ATP binding
.integral component of membrane
.plasma membrane
4 EBI-7131783,EBI-740744 CLDN7  
  .calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
.positive regulation of defense response to virus by host
.identical protein binding
.structural molecule activity
.lateral plasma membrane
.basolateral plasma membrane
.integral component of membrane
.tight junction
5 EBI-7131783,EBI-7361096 TSPAN15  
  .establishment of protein localization to plasma membrane
.protein maturation
.enzyme binding .tetraspanin-enriched microdomain
.extracellular exosome
.integral component of membrane
  + 2 more...
6 EBI-7131783,EBI-10197617 SFTPC  
  .cellular response to nitric oxide
.cellular response to mechanical stimulus
.response to growth factor
  + 11 more...
.N/A .alveolar lamellar body
.multivesicular body
.extracellular space
7 EBI-7131783,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
8 EBI-7131783,EBI-4319440 EMP1  
  .bleb assembly
.cell growth
.epidermis development
  + 3 more...
.N/A .integral component of membrane
.membrane
.plasma membrane
9 EBI-7131783,EBI-10215641 CLDN8  
  .calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules .identical protein binding
.structural molecule activity
.basolateral plasma membrane
.integral component of membrane
.tight junction
  + 2 more...
10 EBI-7131783,EBI-10215665 EDDM3B  
  .N/A .N/A .extracellular region
11 EBI-7131783,EBI-3911467 CXCL9  
  .positive regulation of myoblast fusion
.chemokine-mediated signaling pathway
.defense response to virus
  + 16 more...
.CXCR3 chemokine receptor binding
.chemokine activity
.cytokine activity
.external side of plasma membrane
.extracellular space
.extracellular region
12 EBI-7131783,EBI-1268321 CD47  
  .leukocyte migration
.positive regulation of T cell activation
.positive regulation of phagocytosis
  + 9 more...
.thrombospondin receptor activity .extracellular exosome
.integral component of plasma membrane
.plasma membrane
13 EBI-7131783,EBI-8633987 TMEM115  
  .protein transport
.negative regulation of cell proliferation
.retrograde vesicle-mediated transport, Golgi to ER
.protein glycosylation
.identical protein binding .Golgi cisterna membrane
.integral component of membrane
.Golgi apparatus
.nucleus
14 EBI-7131783,EBI-750078 MALL  
  .cholesterol homeostasis .N/A .membrane raft
.clathrin-coated vesicle
.cytoplasmic membrane-bounded vesicle
  + 3 more...
15 EBI-7131783,EBI-742673 SEC23B  
  .vesicle-mediated transport
.ER to Golgi vesicle-mediated transport
.intracellular protein transport
.zinc ion binding .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 5 more...
16 EBI-7131783,EBI-2903088 OCLN  
  .tight junction assembly
.S-adenosylmethionine metabolic process
.S-adenosylhomocysteine metabolic process
  + 5 more...
.protein domain specific binding
.thiopurine S-methyltransferase activity
.cytoplasmic vesicle
.endocytic vesicle
.cell junction
  + 7 more...
17 EBI-7131783,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
18 EBI-7131783,EBI-10243654 TTMP  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum membrane
19 EBI-7131783,EBI-10244198 DEFB121  
  .innate immune response
.defense response to bacterium
.N/A .cell surface
.extracellular region
20 EBI-7131783,EBI-10246897 RIPPLY2  
  .bone morphogenesis
.post-anal tail morphogenesis
.somite rostral/caudal axis specification
  + 5 more...
.N/A .nucleus
21 EBI-7131783,EBI-10254180 BRICD5  
  .N/A .N/A .integral component of membrane
22 EBI-7131783,EBI-2804156 OLFM4  
  .positive regulation of substrate adhesion-dependent cell spreading
.protein homooligomerization
.negative regulation of immune response
  + 2 more...
.cadherin binding
.protein homodimerization activity
.catalytic activity
.extracellular exosome
.perinuclear region of cytoplasm
.specific granule
  + 3 more...
23 EBI-7131783,EBI-10255122 TMEM182  
  .N/A .N/A .integral component of membrane
24 EBI-7131783,EBI-359761 KTN1  
  .small GTPase mediated signal transduction
.microtubule-based movement
.poly(A) RNA binding .integral component of membrane
.membrane
.integral component of plasma membrane
  + 2 more...
25 EBI-7131783,EBI-749955 TRIM69  
  .apoptotic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nuclear speck
.plasma membrane
.cytoplasm
.nucleus
26 EBI-7131783,EBI-10267100 CSGALNACT2  
  .chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
.dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
.dermatan sulfate proteoglycan biosynthetic process
  + 7 more...
.glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
.metal ion binding
.acetylgalactosaminyltransferase activity
.Golgi cisterna membrane
.integral component of Golgi membrane
.membrane
.Golgi membrane
27 EBI-7131783,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
28 EBI-7131783,EBI-2548784 C10orf35  
  .N/A .N/A .integral component of membrane
29 EBI-7131783,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
30 EBI-7131783,EBI-750770 KLRG1  
  .regulation of immune response
.innate immune response
.cell surface receptor signaling pathway
  + 2 more...
.carbohydrate binding
.receptor activity
.integral component of membrane
.plasma membrane
31 EBI-7131783,EBI-8652744 SEC22A  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
32 EBI-7131783,EBI-741885 CEP19  
  .N/A .N/A .ciliary basal body
.centriole
.spindle pole
33 EBI-7131783,EBI-348587 TMEM147  
  .protein destabilization .N/A .integral component of membrane
.endoplasmic reticulum membrane
34 EBI-7131783,EBI-3939278 CLEC7A  
  .innate immune response
.defense response to protozoan
.T cell activation
  + 6 more...
.metal ion binding
.MHC protein binding
.carbohydrate binding
.signaling pattern recognition receptor activity
.integral component of membrane
.plasma membrane
.cytoplasm
35 EBI-7131783,EBI-714881 SENP2  
  .regulation of G1/S transition of mitotic cell cycle
.spongiotrophoblast layer development
.labyrinthine layer development
  + 21 more...
.SUMO-specific protease activity .nuclear membrane
.cytoplasmic vesicle
.PML body
  + 2 more...
36 EBI-7131783,EBI-8640191 SMCO4  
  .N/A .N/A .integral component of membrane
37 EBI-7131783,EBI-10312990 TMPRSS4  
  .proteolysis .scavenger receptor activity
.serine-type endopeptidase activity
.integral component of membrane
38 EBI-7131783,EBI-949319 KLC4  
  .N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
39 EBI-7131783,EBI-2844246 TMEM140  
  .N/A .N/A .integral component of membrane
40 EBI-7131783,EBI-10314986 TMEM248  
  .N/A .N/A .integral component of membrane
41 EBI-7131783,EBI-10316423 PAQR5  
  .oogenesis
.multicellular organismal development
.steroid binding
.receptor activity
.integral component of membrane
42 EBI-7131783,EBI-10317612 MARCH2  
  .protein ubiquitination
.endocytosis
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasmic vesicle
.integral component of membrane
.endosome membrane
  + 3 more...
43 EBI-7131783,EBI-723716 VTI1B  
  .regulation of protein localization to plasma membrane
.membrane fusion
.vesicle fusion with Golgi apparatus
  + 8 more...
.chloride channel inhibitor activity
.SNAP receptor activity
.SNARE binding
.recycling endosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 11 more...
44 EBI-7131783,EBI-2602396 ABT1  
  .small-subunit processome assembly
.spinal cord motor neuron differentiation
.transcription from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.transcription coactivator activity
.DNA binding
.nucleotide binding
.nucleolus
.transcription factor complex
.nucleus
45 EBI-7131783,EBI-2866431 ITM2B  
  .extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of amyloid precursor protein biosynthetic process
.nervous system development
.ATP binding
.beta-amyloid binding
.extracellular exosome
.intracellular membrane-bounded organelle
.integral component of organelle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain3
kidney14
liver4
lung8
lymph node11
mammary gland26
pancreas4
pituitary gland60
placenta7
prostate5
skin4
thymus25
uterus4
Health State
TissuesTPM*
normal4
breast (mammary gland) tumor21
pancreatic tumor9
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult7
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
colon1.8
duodenum3
gallbladder2.2
kidney4.5
liver2.4
lung3.8
lymph node1.1
pancreas2.1
placenta2.3
prostate10.9
salivary gland8.7
small intestine1.6
stomach3
thyroid gland6.7
urinary bladder1.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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