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> Protein (NX_Q8N264)
Protein (NX_Q8N264)
Protein
Gene SymbolARHGAP24 to neXtProt (NX_Q8N264)
DescriptionRho GTPase-activating protein 24
Chromosome4
Location4q21.23 (86396267 ~ 86923823) to Ensembl
Sequene Features : Isoforms 5, Variants 110, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of ruffle assembly
.regulation of small GTPase mediated signal transduction
.wound healing, spreading of epidermal cells
  + 4 more...
.GTPase activator activity .cell projection
.focal adhesion
.cytoskeleton
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 110 7
2014-09-19protein level
5 84 7
2014-05-27protein level
5 84 7
2014-02-25protein level
5 83 7
2013-12-09protein level
5 61 7
2013-11-01protein level
5 60 7
2013-09-12protein level
5 60 7
2013-08-17protein level
5 60 7
2013-07-15protein level
5 41 7
2013-06-11protein level
5 41 7
2013-02-12protein level
5 25 18
2012-12-20protein level
5 28 18
2012-10-30protein level
5 33 18
2012-10-07protein level
5 33 6
2012-08-24protein level
5 32 6
2012-07-28protein level
5 31 6
2012-06-08protein level
5 5 6
2012-05-07protein level
5 5 6
2012-04-10protein level
5 5 6
2012-01-13protein level
5 5 6
2011-12-20protein level
5 7 6
2011-11-11protein level
5 7 6
2011-08-23protein level
5 7 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N264-1
0 31 0 84205.1519
NX_Q8N264-2
1 24 0 73363.0618
NX_Q8N264-3
0 26 0 73243.8617
NX_Q8N264-4
0 12 0 28230.9464
NX_Q8N264-5
9 3 0 28202.2767
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-988764,EBI-350432 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
2 EBI-988764,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
ascites25
bladder33
blood32
brain11
connective tissue60
ear124
eye28
heart44
intestine8
kidney166
liver14
lung26
lymph node44
mammary gland39
mouth60
muscle18
nerve64
ovary39
pancreas28
pharynx24
placenta28
skin42
stomach52
testis11
thymus50
thyroid42
trachea77
umbilical cord217
uterus12
vascular348
Health State
TissuesTPM*
normal41
breast (mammary gland) tumor64
chondrosarcoma36
gastrointestinal tumor50
glioma18
head and neck tumor29
kidney tumor14
leukemia31
liver tumor31
lung tumor9
lymphoma69
non-neoplasia31
ovarian tumor39
primitive neuroectodermal tumor of the CNS23
skin tumor7
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult25
neonate128
fetus52
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.1
adrenal gland3
appendix9.6
bone marrow23.5
cerebral cortex5
colon6.2
duodenum6.8
esophagus9.5
gallbladder15.8
heart muscle32.9
kidney89.6
liver5.9
lung17
lymph node16.4
ovary7.2
pancreas17.8
placenta22.9
prostate5
salivary gland9.6
skin8.2
small intestine5.2
spleen19.7
stomach24.2
testis4.5
thyroid gland27.4
urinary bladder15.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610586, gene) Rho gtpase-activating protein 24; ARHGAP24OMIM


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