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> Protein (NX_Q8N2W9)
Protein (NX_Q8N2W9)
Protein
Gene SymbolPIAS4 to neXtProt (NX_Q8N2W9)
DescriptionE3 SUMO-protein ligase PIAS4
Chromosome19
Location19p13.3 (4007644 ~ 4039384) to Ensembl
Sequene Features : Isoforms 1, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of keratinocyte apoptotic process
.negative regulation of transcription, DNA-templated
  + 8 more...
.SUMO ligase activity
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 3 more...
.PML body
.nuclear matrix
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 53 8
2014-09-19protein level
1 42 8
2014-05-27protein level
1 42 8
2014-02-25protein level
1 42 8
2013-12-09protein level
1 36 8
2013-11-01protein level
1 32 8
2013-09-12protein level
1 32 8
2013-08-17protein level
1 32 8
2013-07-15protein level
1 23 3
2013-06-11protein level
1 23 3
2013-02-12protein level
1 14 5
2012-12-20protein level
1 14 5
2012-10-30protein level
1 14 5
2012-10-07protein level
1 14 5
2012-08-24protein level
1 13 5
2012-07-28protein level
1 13 5
2012-06-08protein level
1 22 5
2012-05-07protein level
1 20 5
2012-04-10protein level
1 20 5
2012-01-13protein level
1 14 5
2011-12-20protein level
1 14 5
2011-11-11protein level
1 14 5
2011-08-23protein level
1 14 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N2W9-1
19 0 0 56467.5429
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473160,EBI-473249 TADA3  
  .regulation of tubulin deacetylation
.positive regulation of transcription, DNA-templated
.histone H3 acetylation
  + 9 more...
.ligand-dependent nuclear receptor transcription coactivator activity
.protein domain specific binding
.ligand-dependent nuclear receptor binding
  + 2 more...
.mitotic spindle
.transcription factor TFTC complex
.STAGA complex
  + 4 more...
2 EBI-473160,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-473160,EBI-355676 PARP1  
  .positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
4 EBI-473160,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-473160,EBI-473220 SUMO2  
  .positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.PML body
.nucleoplasm
.nucleus
6 EBI-473160,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood24
bone41
bone marrow20
brain30
cervix41
connective tissue33
embryonic tissue61
eye38
intestine38
kidney18
liver9
lung14
lymph node22
mammary gland33
mouth15
muscle9
nerve64
ovary39
pancreas51
placenta35
prostate47
skin18
spleen37
stomach20
testis215
thymus12
thyroid21
tonsil58
trachea19
uterus4
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor25
germ cell tumor30
glioma65
head and neck tumor14
kidney tumor29
leukemia42
liver tumor10
lymphoma13
non-neoplasia41
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult24
embryoid body57
blastocyst97
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.8
adrenal gland7.1
appendix11
bone marrow5.5
cerebral cortex10.3
colon9
duodenum13.5
esophagus7.5
gallbladder5.7
heart muscle3.5
kidney8.7
liver4.8
lung6.3
lymph node9.6
ovary8.6
pancreas6.4
placenta10
prostate9.3
salivary gland8.8
skin6.1
small intestine11
spleen11.8
stomach12.5
testis45.1
thyroid gland3.8
urinary bladder12.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605989, gene) Protein inhibitor of activated stat4; PIAS4OMIM


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