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> Protein (NX_Q8N488)
Protein (NX_Q8N488)
Protein
Gene SymbolRYBP to neXtProt (NX_Q8N488)
DescriptionRING1 and YY1-binding protein
Chromosome3
Location3p13 (72420976 ~ 72496069) to Ensembl
Sequene Features : Isoforms 1, Variants 0, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H2A monoubiquitination
.multicellular organismal development
.apoptotic process
  + 2 more...
.zinc ion binding
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 0 7
2014-09-19protein level
1 0 7
2014-05-27protein level
1 0 7
2014-02-25protein level
1 0 7
2013-12-09protein level
1 0 7
2013-11-01protein level
1 0 6
2013-09-12protein level
1 0 6
2013-08-17protein level
1 0 6
2013-07-15protein level
1 0 6
2013-06-11protein level
1 0 6
2013-02-12protein level
1 0 5
2012-12-20protein level
1 0 5
2012-10-30protein level
1 0 5
2012-10-07protein level
1 0 5
2012-08-24protein level
1 0 5
2012-07-28protein level
1 0 5
2012-06-08protein level
1 1 5
2012-05-07protein level
1 1 5
2012-04-10protein level
1 1 5
2012-01-13protein level
1 1 5
2011-12-20protein level
1 4 5
2011-11-11protein level
1 4 4
2011-08-23protein level
1 4 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N488-1
8 0 0 24806.381
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-752324,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-752324,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-752324,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
4 EBI-752324,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder133
blood65
bone69
bone marrow41
brain34
connective tissue80
embryonic tissue37
eye76
heart111
intestine38
kidney75
liver29
lung101
lymph node133
mammary gland39
muscle47
nerve64
ovary39
pancreas70
parathyroid48
pharynx49
pituitary gland60
placenta254
prostate100
skin80
spleen18
stomach41
testis91
thymus12
thyroid85
tonsil58
uterus112
vascular19
Health State
TissuesTPM*
normal90
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor42
chondrosarcoma132
colorectal tumor26
gastrointestinal tumor42
germ cell tumor83
glioma102
head and neck tumor37
kidney tumor58
leukemia63
liver tumor20
lung tumor48
non-neoplasia51
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer96
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor66
Developmental Stage
TissuesTPM*
adult80
embryoid body28
blastocyst16
fetus131
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10
adrenal gland9.7
appendix11.6
bone marrow10.6
cerebral cortex11.7
colon11.1
duodenum8.6
esophagus11
gallbladder13.3
heart muscle5.2
kidney9.4
liver8.4
lung11.4
lymph node10.5
ovary14.1
pancreas4.7
placenta27.7
prostate14.4
salivary gland5.5
skin7
small intestine9.3
spleen12.8
stomach8.1
testis15.2
thyroid gland9.2
urinary bladder12.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607535, gene) Ring1- and yy1-binding protein; RYBPOMIM


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