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> Protein (NX_Q8N4L8)
Protein (NX_Q8N4L8)
Protein
Gene SymbolCCDC24 to neXtProt (NX_Q8N4L8)
DescriptionCoiled-coil domain-containing protein 24
Chromosome1
Location1p34.1 (44457031 ~ 44462200) to Ensembl
Sequene Features : Isoforms 2, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
2 35 0
2014-09-19transcript level
2 32 0
2014-05-27transcript level
2 32 0
2014-02-25transcript level
2 32 0
2013-12-09transcript level
2 24 0
2013-11-01transcript level
2 24 0
2013-09-12transcript level
2 24 0
2013-08-17transcript level
2 24 0
2013-07-15transcript level
2 16 0
2013-06-11transcript level
2 16 0
2013-02-12transcript level
2 10 0
2012-12-20transcript level
2 10 0
2012-10-30transcript level
2 11 0
2012-10-07transcript level
2 11 0
2012-08-24transcript level
2 11 0
2012-07-28transcript level
2 11 0
2012-06-08transcript level
2 12 0
2012-05-07transcript level
2 10 0
2012-04-10transcript level
2 10 0
2012-01-13transcript level
2 5 0
2011-12-20transcript level
2 5 0
2011-11-11transcript level
2 5 0
2011-08-23transcript level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N4L8-1
1 12 0 34300.6433
NX_Q8N4L8-2
0 12 0 30522.5619
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1104933,EBI-3909284 GATA1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of transcription regulatory region DNA binding
.cellular response to thyroid hormone stimulus
  + 26 more...
.C2H2 zinc finger domain binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 12 more...
.transcriptional repressor complex
.transcription factor complex
.nucleoplasm
.nucleus
2 EBI-1104933,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
3 EBI-1104933,EBI-10225152 RNF31  
  .positive regulation of protein targeting to mitochondrion
.protein linear polyubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 4 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.LUBAC complex
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytoplasm
4 EBI-1104933,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bone27
brain7
cervix41
connective tissue6
embryonic tissue9
eye19
intestine4
liver4
lung26
lymph node66
ovary19
pancreas14
parathyroid48
prostate21
skin4
stomach31
thymus12
uterus12
Health State
TissuesTPM*
normal11
chondrosarcoma24
gastrointestinal tumor16
germ cell tumor3
glioma9
leukemia21
liver tumor10
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult12
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2
adrenal gland6.9
appendix3.7
cerebral cortex6.4
colon6
duodenum5.1
esophagus3
gallbladder9
heart muscle1.7
kidney10.2
liver2.6
lung6.9
lymph node3.1
ovary4.2
pancreas4.4
placenta2.9
prostate11.6
salivary gland10.5
skin2.1
small intestine2.6
spleen4.2
stomach8.6
testis23.7
thyroid gland14.8
urinary bladder5.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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