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> Protein (NX_Q8N4P3)
Protein (NX_Q8N4P3)
Protein
Gene SymbolHDDC3 to neXtProt (NX_Q8N4P3)
DescriptionGuanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Chromosome15
Location15q26.1 (91474148 ~ 91475799) to Ensembl
Sequene Features : Isoforms 2, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .metal ion binding
.guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 14 6
2014-09-19protein level
2 10 6
2014-05-27protein level
2 10 6
2014-02-25protein level
2 10 6
2013-12-09protein level
2 8 6
2013-11-01protein level
2 8 4
2013-09-12protein level
2 8 4
2013-08-17protein level
2 8 4
2013-07-15protein level
2 5 3
2013-06-11protein level
2 5 3
2013-02-12protein level
2 3 6
2012-12-20protein level
2 3 6
2012-10-30protein level
2 4 6
2012-10-07protein level
2 4 3
2012-08-24protein level
2 3 3
2012-07-28protein level
2 3 3
2012-06-08protein level
2 6 3
2012-05-07protein level
2 6 3
2012-04-10protein level
2 6 3
2012-01-13protein level
2 3 3
2011-12-20protein level
2 3 3
2011-11-11protein level
2 3 3
2011-08-23protein level
2 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N4P3-1
2 5 0 20316.6077
NX_Q8N4P3-2
0 5 0 15723.2791
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-750003,EBI-2548868 CCDC172  
  .N/A .N/A .N/A
2 EBI-750003,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
3 EBI-750003,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
4 EBI-750003,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
5 EBI-750003,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
6 EBI-750003,EBI-743722 GKAP1  
  .signal transduction .N/A .Golgi apparatus
7 EBI-750003,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
blood24
bone13
brain6
cervix61
embryonic tissue14
eye28
heart22
intestine8
kidney18
lung29
lymph node33
mammary gland13
muscle18
pancreas37
parathyroid48
placenta14
prostate26
skin9
testis9
thymus25
uterus4
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor33
germ cell tumor34
glioma37
kidney tumor14
leukemia21
lymphoma27
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer19
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult11
embryoid body14
blastocyst16
fetus25
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland16.3
appendix10.6
bone marrow9.8
cerebral cortex9.5
colon15.7
duodenum15.6
esophagus8.5
gallbladder9.5
heart muscle13.8
kidney17.2
liver9.6
lung10.6
lymph node15.2
ovary11.5
pancreas14.2
placenta10.7
prostate10.6
salivary gland20.5
skin9.1
small intestine14.1
spleen15.4
stomach13.8
testis6.8
thyroid gland17.7
urinary bladder12
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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