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> Protein (NX_Q8N4X5)
Protein (NX_Q8N4X5)
Protein
Gene SymbolAFAP1L2 to neXtProt (NX_Q8N4X5)
DescriptionActin filament-associated protein 1-like 2
Chromosome10
Location10q25.3 (116054583 ~ 116164515) to Ensembl
Sequene Features : Isoforms 4, Variants 111, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein tyrosine kinase activity
.positive regulation of transcription, DNA-templated
.positive regulation of epidermal growth factor receptor signaling pathway
  + 4 more...
.SH2 domain binding
.signaling adaptor activity
.protein tyrosine kinase activator activity
.SH3 domain binding
.plasma membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 111 7
2014-09-19protein level
4 91 7
2014-05-27protein level
4 91 7
2014-02-25protein level
4 89 7
2013-12-09protein level
4 69 7
2013-11-01protein level
4 66 7
2013-09-12protein level
4 66 8
2013-08-17protein level
4 66 8
2013-07-15protein level
4 53 8
2013-06-11protein level
4 53 8
2013-02-12protein level
4 34 20
2012-12-20protein level
4 34 20
2012-10-30protein level
4 35 20
2012-10-07protein level
4 35 6
2012-08-24protein level
4 31 6
2012-07-28protein level
4 31 6
2012-06-08protein level
4 13 6
2012-05-07protein level
4 13 6
2012-04-10protein level
4 13 6
2012-01-13protein level
4 13 6
2011-12-20protein level
4 13 6
2011-11-11protein level
4 13 6
2011-08-23protein level
4 13 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N4X5-1
0 35 0 91242.8514
NX_Q8N4X5-2
0 35 0 90803.5985
NX_Q8N4X5-3
1 11 0 38276.4271
NX_Q8N4X5-4
2 34 0 93835.2293
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood24
brain34
ear62
embryonic tissue18
esophagus49
eye28
heart11
intestine30
kidney28
larynx42
liver4
lung11
mammary gland19
muscle37
ovary68
pancreas14
parathyroid97
placenta52
prostate42
skin4
spleen93
stomach10
testis13
thymus37
thyroid193
trachea38
uterus43
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor32
chondrosarcoma12
colorectal tumor8
esophageal tumor57
germ cell tumor18
glioma46
head and neck tumor74
kidney tumor58
leukemia21
liver tumor10
non-neoplasia10
ovarian tumor78
pancreatic tumor28
primitive neuroectodermal tumor of the CNS55
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult31
embryoid body42
fetus23
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.6
adrenal gland3
appendix5.1
cerebral cortex15.3
colon8.7
duodenum4.5
esophagus9.5
gallbladder5.5
heart muscle4.1
kidney20.4
lung7.7
lymph node5.5
ovary15.2
pancreas6.2
placenta17.2
prostate15
salivary gland5.5
skin11.7
small intestine5.4
spleen67.9
stomach3.4
testis2.3
thyroid gland89.9
urinary bladder6.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612420, gene) Actin filament-associated protein 1-like protein 2; AFAP1L2OMIM


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