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> Protein (NX_Q8N5H7)
Protein (NX_Q8N5H7)
Protein
Gene SymbolSH2D3C to neXtProt (NX_Q8N5H7)
DescriptionSH2 domain-containing protein 3C
Chromosome9
Location9q34.11 (130500596 ~ 130541020) to Ensembl
Sequene Features : Isoforms 6, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of signal transduction
.small GTPase mediated signal transduction
.JNK cascade
.guanyl-nucleotide exchange factor activity
.SH3/SH2 adaptor activity
.membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 105 7
2014-09-19protein level
6 77 7
2014-05-27protein level
6 77 7
2014-02-25protein level
6 75 7
2013-12-09protein level
6 58 7
2013-11-01protein level
6 56 7
2013-09-12protein level
6 56 7
2013-08-17protein level
6 56 7
2013-07-15protein level
6 43 7
2013-06-11protein level
6 43 7
2013-02-12protein level
6 22 19
2012-12-20protein level
6 23 19
2012-10-30protein level
5 27 16
2012-10-07protein level
5 27 4
2012-08-24protein level
5 20 4
2012-07-28protein level
5 19 4
2012-06-08protein level
5 20 4
2012-05-07protein level
5 20 4
2012-04-10protein level
5 20 4
2012-01-13protein level
5 10 4
2011-12-20protein level
5 10 4
2011-11-11protein level
5 10 4
2011-08-23protein level
4 10 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N5H7-1
8 30 1 94351.7138
NX_Q8N5H7-2
1 30 1 77092.1128
NX_Q8N5H7-3
0 24 0 55155.9921
NX_Q8N5H7-4
6 30 1 86381.7493
NX_Q8N5H7-5
1 31 1 77300.1185
NX_Q8N5H7-6
1 31 1 77072.9922
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745980,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
2 EBI-745980,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
blood122
brain62
connective tissue33
embryonic tissue9
eye19
heart100
intestine21
kidney47
lung68
lymph node200
mammary gland6
mouth60
muscle37
nerve64
ovary9
placenta45
prostate26
skin28
spleen337
stomach20
testis13
thymus1141
tonsil117
trachea38
uterus25
vascular116
Health State
TissuesTPM*
normal65
breast (mammary gland) tumor10
gastrointestinal tumor16
germ cell tumor45
glioma9
head and neck tumor7
kidney tumor14
leukemia127
lymphoma41
non-neoplasia51
primitive neuroectodermal tumor of the CNS7
prostate cancer9
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
embryoid body28
fetus73
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.6
adrenal gland5
appendix12.9
bone marrow7.6
cerebral cortex7.8
colon3.6
duodenum3.8
esophagus3.9
gallbladder9.6
heart muscle13.7
kidney7.2
liver1.4
lung31.5
lymph node23
ovary2.4
pancreas1.6
placenta12.7
prostate4.8
salivary gland3.5
skin3.6
small intestine4.2
spleen36.1
stomach5.7
testis3.7
thyroid gland9.2
urinary bladder10.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604722, gene) Sh2 domain-containing protein 3c; SH2D3COMIM


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