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> Protein (NX_Q8N5L8)
Protein (NX_Q8N5L8)
Protein
Gene SymbolRPP25L to neXtProt (NX_Q8N5L8)
DescriptionRibonuclease P protein subunit p25-like protein
Chromosome9
Location9p13.3 (34610483 ~ 34612101) to Ensembl
Sequene Features : Isoforms 1, Variants 4, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .poly(A) RNA binding .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 4 1
2014-09-19protein level
1 18 1
2014-05-27protein level
1 18 1
2014-02-25protein level
1 17 1
2013-12-09protein level
1 15 1
2013-11-01protein level
1 15 0
2013-09-12protein level
1 15 0
2013-08-17protein level
1 15 0
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 1 0
2012-10-07protein level
1 1 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 0 0
2011-12-20protein level
1 0 0
2011-11-11protein level
1 0 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N5L8-1
8 0 0 17620.1275
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10189722,EBI-366574 POP7  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.tRNA processing
.poly(A) RNA binding
.ribonuclease P activity
.mitochondrial ribonuclease P complex
.nucleolar ribonuclease P complex
.nucleus
2 EBI-10189722,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
3 EBI-10189722,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
4 EBI-10189722,EBI-302405 ARHGEF2  
  .negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.apoptotic signaling pathway
  + 25 more...
.Rac GTPase binding
.Rac guanyl-nucleotide exchange factor activity
.Rho GTPase binding
  + 4 more...
.protein complex
.dendritic shaft
.neuronal cell body
  + 11 more...
5 EBI-10189722,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
6 EBI-10189722,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood16
bone13
brain18
connective tissue6
embryonic tissue23
eye33
heart89
intestine17
kidney42
liver9
lung38
lymph135
lymph node44
mammary gland6
mouth15
muscle37
ovary19
pancreas37
parathyroid145
placenta17
prostate52
skin42
stomach10
testis18
thymus37
thyroid21
uterus38
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor16
germ cell tumor11
glioma83
head and neck tumor7
kidney tumor14
leukemia42
liver tumor20
lung tumor29
lymphoma83
non-neoplasia10
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer48
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult24
embryoid body14
fetus39
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.6
adrenal gland14.9
appendix12.2
bone marrow5.8
cerebral cortex10.3
colon18.7
duodenum22.8
esophagus18.5
gallbladder15.3
heart muscle27.5
kidney20.4
liver16.2
lung10.5
lymph node18.9
ovary17.6
pancreas10.2
placenta13.7
prostate19.5
salivary gland16.2
skin13.7
small intestine21.8
spleen16.8
stomach15.2
testis10.5
thyroid gland16.6
urinary bladder20.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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