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> Protein (NX_Q8N5M1)
Protein (NX_Q8N5M1)
Protein
Gene SymbolATPAF2 to neXtProt (NX_Q8N5M1)
DescriptionATP synthase mitochondrial F1 complex assembly factor 2
Chromosome17
Location17p11.2 (17880723 ~ 17942523) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 1
2014-09-19protein level
1 23 1
2014-05-27protein level
1 23 1
2014-02-25protein level
1 23 0
2013-12-09protein level
1 18 0
2013-11-01protein level
1 18 0
2013-09-12protein level
1 18 0
2013-08-17protein level
1 18 0
2013-07-15protein level
1 16 0
2013-06-11protein level
1 16 0
2013-02-12protein level
1 10 0
2012-12-20protein level
1 9 0
2012-10-30protein level
1 12 0
2012-10-07protein level
1 12 0
2012-08-24protein level
1 12 0
2012-07-28protein level
1 12 0
2012-06-08protein level
1 12 0
2012-05-07protein level
1 12 0
2012-04-10protein level
1 12 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N5M1-1
15 0 0 32751.8129
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1166928,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
2 EBI-1166928,EBI-1059030 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
3 EBI-1166928,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-1166928,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
5 EBI-1166928,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-1166928,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
7 EBI-1166928,EBI-744831 RPIA  
  .small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
8 EBI-1166928,EBI-739737 EWSR1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
9 EBI-1166928,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
10 EBI-1166928,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
11 EBI-1166928,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
12 EBI-1166928,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
13 EBI-1166928,EBI-726447 PKP4  
  .positive regulation of GTPase activity
.positive regulation of cytokinesis
.regulation of cell adhesion
  + 3 more...
.N/A .mitotic spindle
.spindle midzone
.perinuclear region of cytoplasm
  + 9 more...
14 EBI-1166928,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
15 EBI-1166928,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
16 EBI-1166928,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
17 EBI-1166928,EBI-765426 EBF1  
  .positive regulation of transcription, DNA-templated
.multicellular organismal development
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
18 EBI-1166928,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
19 EBI-1166928,EBI-1023718 LRRFIP2  
  .Wnt signaling pathway .LRR domain binding .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites125
blood24
bone55
brain26
cervix103
connective tissue13
embryonic tissue18
eye28
heart11
intestine25
kidney37
larynx85
liver24
lung35
lymph22
lymph node77
mammary gland6
muscle65
ovary78
pancreas42
parathyroid145
placenta28
prostate26
skin56
spleen56
stomach20
testis45
thymus112
tonsil58
uterus30
Health State
TissuesTPM*
normal39
adrenal tumor79
cervical tumor86
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor50
germ cell tumor18
glioma27
head and neck tumor14
kidney tumor43
leukemia31
liver tumor20
lung tumor19
lymphoma13
non-neoplasia31
ovarian tumor105
pancreatic tumor47
primitive neuroectodermal tumor of the CNS23
prostate cancer28
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult36
blastocyst32
neonate32
fetus34
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.3
adrenal gland15.4
appendix15.7
bone marrow19.4
cerebral cortex7.5
colon11.3
duodenum10.4
esophagus11.6
gallbladder7.7
heart muscle20.1
kidney13.3
liver7.6
lung11.1
lymph node18.4
ovary8.6
pancreas7.5
placenta12.1
prostate11.7
salivary gland11.9
skin14.3
small intestine12
spleen15
stomach11
testis22.4
thyroid gland15.3
urinary bladder14.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 2Low
small intestineMedium
soft tissue 1Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#604273, phenotype) Mitochondrial complex v (atp synthase) deficiency, nuclear type 1;OMIM
2(*608918, gene) Atp synthase, mitochondrial f1 complex, assembly factor 2; ATPAF2OMIM


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