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> Protein (NX_Q8N684)
Protein (NX_Q8N684)
Protein
Gene SymbolCPSF7 to neXtProt (NX_Q8N684)
DescriptionCleavage and polyadenylation specificity factor subunit 7
Chromosome11
Location11q12.2 (61170121 ~ 61197503) to Ensembl
Sequene Features : Isoforms 3, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 50 5
2014-09-19protein level
3 40 5
2014-05-27protein level
3 40 5
2014-02-25protein level
3 39 5
2013-12-09protein level
3 31 5
2013-11-01protein level
3 30 4
2013-09-12protein level
3 30 4
2013-08-17protein level
3 30 4
2013-07-15protein level
3 22 3
2013-06-11protein level
3 22 3
2013-02-12protein level
3 9 24
2012-12-20protein level
3 9 24
2012-10-30protein level
3 10 24
2012-10-07protein level
3 10 8
2012-08-24protein level
3 6 8
2012-07-28protein level
3 6 8
2012-06-08protein level
3 9 8
2012-05-07protein level
3 5 8
2012-04-10protein level
3 5 8
2012-01-13protein level
3 5 8
2011-12-20protein level
3 5 8
2011-11-11protein level
3 5 8
2011-08-23protein level
3 5 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N684-1
0 22 0 52018.1321
NX_Q8N684-2
0 22 0 51064.6485
NX_Q8N684-3
4 21 0 56340.3869
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746909,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-746909,EBI-355720 NUDT21  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.histone deacetylase binding
.protein homodimerization activity
  + 3 more...
.paraspeckles
.mRNA cleavage factor complex
.centrosome
  + 2 more...
3 EBI-746909,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
4 EBI-746909,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
5 EBI-746909,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
6 EBI-746909,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
7 EBI-746909,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
8 EBI-746909,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
9 EBI-746909,EBI-742673 SEC23B  
  .vesicle-mediated transport
.ER to Golgi vesicle-mediated transport
.intracellular protein transport
.zinc ion binding .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 5 more...
10 EBI-746909,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
11 EBI-746909,EBI-9675976 SNRNP25  
  .RNA splicing
.mRNA processing
.N/A .intercellular bridge
.cytoplasm
.U12-type spliceosomal complex
  + 2 more...
12 EBI-746909,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites100
bladder133
blood81
bone125
bone marrow20
brain127
cervix226
connective tissue67
embryonic tissue187
esophagus49
eye43
heart33
intestine107
kidney47
larynx170
liver43
lung68
lymph90
lymph node44
mammary gland119
mouth196
muscle28
nerve64
ovary59
pancreas84
parathyroid48
pituitary gland60
placenta109
prostate73
salivary gland98
skin94
spleen37
stomach52
testis149
thymus175
thyroid42
tonsil58
trachea289
umbilical cord72
uterus120
vascular19
Health State
TissuesTPM*
normal90
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor53
cervical tumor318
chondrosarcoma156
colorectal tumor115
esophageal tumor57
gastrointestinal tumor84
germ cell tumor121
glioma55
head and neck tumor149
kidney tumor43
leukemia74
liver tumor31
lung tumor77
lymphoma110
non-neoplasia31
ovarian tumor65
pancreatic tumor161
primitive neuroectodermal tumor of the CNS39
prostate cancer38
retinoblastoma43
skin tumor127
soft tissue/muscle tissue tumor39
uterine tumor122
Developmental Stage
TissuesTPM*
adult82
embryoid body185
blastocyst195
neonate96
fetus98
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.8
adrenal gland40
appendix43.7
bone marrow39.6
cerebral cortex37.7
colon31.9
duodenum36.6
esophagus32.5
gallbladder37.6
heart muscle27.6
kidney32.4
liver24
lung40.2
lymph node51.9
ovary59.1
pancreas21
placenta45.3
prostate38.1
salivary gland31.8
skin52.4
small intestine39.3
spleen47
stomach35.9
testis47.3
thyroid gland52.3
urinary bladder37.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateLow
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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