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> Protein (NX_Q8N6L0)
Protein (NX_Q8N6L0)
Protein
Gene SymbolCCDC155 to neXtProt (NX_Q8N6L0)
DescriptionProtein KASH5
Chromosome19
Location19q13.33 (49891475 ~ 49921251) to Ensembl
Sequene Features : Isoforms 1, Variants 79, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 79 0
2014-09-19protein level
1 61 0
2014-05-27transcript level
1 61 0
2014-02-25transcript level
1 60 0
2013-12-09transcript level
1 42 0
2013-11-01transcript level
1 42 0
2013-09-12transcript level
1 42 0
2013-08-17transcript level
1 42 0
2013-07-15transcript level
1 22 0
2013-06-11transcript level
1 22 0
2013-02-12transcript level
1 11 0
2012-12-20transcript level
1 11 0
2012-10-30transcript level
1 11 0
2012-10-07transcript level
1 11 0
2012-08-24transcript level
1 10 0
2012-07-28transcript level
1 10 0
2012-06-08transcript level
1 10 0
2012-05-07transcript level
1 7 0
2012-04-10transcript level
1 7 0
2012-01-13transcript level
1 5 0
2011-12-20transcript level
1 5 0
2011-11-11transcript level
1 5 0
2011-08-23transcript level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N6L0-1
24 0 0 62743.7829
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749265,EBI-10178951 GPR25  
  .G-protein coupled receptor signaling pathway .G-protein coupled receptor activity .integral component of plasma membrane
2 EBI-749265,EBI-10179682 UPK2  
  .membrane organization
.epithelial cell differentiation
.multicellular organismal development
.N/A .extracellular exosome
.integral component of endoplasmic reticulum membrane
.apical plasma membrane
.integral component of plasma membrane
3 EBI-749265,EBI-10180786 SLN  
  .regulation of calcium-transporting ATPase activity
.positive regulation of protein depolymerization
.negative regulation of calcium ion binding
  + 8 more...
.ATPase binding
.enzyme inhibitor activity
.sarcoplasmic reticulum membrane
.sarcoplasmic reticulum
.integral component of membrane
4 EBI-749265,EBI-4401517 GOSR2  
  .membrane fusion
.vesicle fusion with Golgi apparatus
.cellular protein metabolic process
  + 7 more...
.SNAP receptor activity
.transporter activity
.SNARE binding
.late endosome membrane
.SNARE complex
.integral component of membrane
  + 5 more...
5 EBI-749265,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
6 EBI-749265,EBI-744953 VAMP4  
  .Golgi ribbon formation
.regulation of Golgi to plasma membrane protein transport
.SNARE complex assembly
  + 2 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.cell surface
  + 5 more...
7 EBI-749265,EBI-7415268 MTX2  
  .cellular protein metabolic process
.mitochondrial transport
.protein targeting to mitochondrion
.N/A .mitochondrial outer membrane
8 EBI-749265,EBI-2947137 STBD1  
  .muscle contraction .starch binding .membrane
.integral component of plasma membrane
9 EBI-749265,EBI-10192648 FTCD  
  .small molecule metabolic process
.tetrahydrofolate interconversion
.cellular nitrogen compound metabolic process
  + 5 more...
.formimidoyltetrahydrofolate cyclodeaminase activity
.glutamate formimidoyltransferase activity
.folic acid binding
.extracellular exosome
.cytosol
.centriole
  + 2 more...
10 EBI-749265,EBI-2808234 MS4A1  
  .B cell proliferation
.humoral immune response
.MHC class II protein complex binding .extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.extracellular space
11 EBI-749265,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
12 EBI-749265,EBI-2861522 PDGFRA  
  .regulation of mesenchymal stem cell differentiation
.regulation of actin cytoskeleton reorganization
.metanephric glomerular capillary formation
  + 47 more...
.platelet-derived growth factor binding
.protein homodimerization activity
.vascular endothelial growth factor binding
  + 6 more...
.protein complex
.intrinsic component of plasma membrane
.membrane
  + 6 more...
13 EBI-749265,EBI-765623 ATF7  
  .viral process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.mitogen-activated protein kinase binding
.metal ion binding
.sequence-specific DNA binding
  + 5 more...
.nuclear periphery
.cytoplasm
.nucleoplasm
.nucleus
14 EBI-749265,EBI-10201335 VAMP1  
  .SNARE complex assembly
.vesicle fusion
.exocytosis
.SNAP receptor activity
.SNARE binding
.tertiary granule membrane
.neuron projection
.specific granule membrane
  + 8 more...
15 EBI-749265,EBI-10204806 CRABP2  
  .embryonic forelimb morphogenesis
.epidermis development
.signal transduction
  + 2 more...
.retinol binding
.retinal binding
.retinoid binding
  + 2 more...
.extracellular exosome
.cytosol
.endoplasmic reticulum
  + 2 more...
16 EBI-749265,EBI-6380741 NSG1  
  .clathrin coat assembly
.dopamine receptor signaling pathway
.N/A .postsynaptic membrane
.lateral plasma membrane
.integral component of membrane
  + 4 more...
17 EBI-749265,EBI-992788 MMP14  
  .craniofacial suture morphogenesis
.negative regulation of focal adhesion assembly
.tissue remodeling
  + 22 more...
.peptidase activator activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.melanosome
.extracellular matrix
.focal adhesion
  + 3 more...
18 EBI-749265,EBI-10215641 CLDN8  
  .calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules .identical protein binding
.structural molecule activity
.basolateral plasma membrane
.integral component of membrane
.tight junction
  + 2 more...
19 EBI-749265,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
20 EBI-749265,EBI-608347 PLP2  
  .ion transmembrane transport
.cytokine-mediated signaling pathway
.chemotaxis
.ion transport
.chemokine binding
.ion transmembrane transporter activity
.extracellular exosome
.integral component of membrane
.membrane
  + 3 more...
21 EBI-749265,EBI-3911467 CXCL9  
  .positive regulation of myoblast fusion
.chemokine-mediated signaling pathway
.defense response to virus
  + 16 more...
.CXCR3 chemokine receptor binding
.chemokine activity
.cytokine activity
.external side of plasma membrane
.extracellular space
.extracellular region
22 EBI-749265,EBI-10226985 GALNT2  
  .cellular protein metabolic process
.post-translational protein modification
.protein O-linked glycosylation via threonine
  + 4 more...
.carbohydrate binding
.manganese ion binding
.polypeptide N-acetylgalactosaminyltransferase activity
.extracellular exosome
.perinuclear region of cytoplasm
.Golgi cisterna membrane
  + 5 more...
23 EBI-749265,EBI-750078 MALL  
  .cholesterol homeostasis .N/A .membrane raft
.clathrin-coated vesicle
.cytoplasmic membrane-bounded vesicle
  + 3 more...
24 EBI-749265,EBI-714206 STX5  
  .regulation of Golgi organization
.Golgi disassembly
.vesicle fusion with Golgi apparatus
  + 7 more...
.protein N-terminus binding
.SNAP receptor activity
.SNARE binding
.endoplasmic reticulum-Golgi intermediate compartment membrane
.vesicle
.SNARE complex
  + 5 more...
25 EBI-749265,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
26 EBI-749265,EBI-10244780 RTP2  
  .protein insertion into membrane .olfactory receptor binding .integral component of membrane
.cell surface
.plasma membrane
27 EBI-749265,EBI-2372076 GPATCH4  
  .N/A .poly(A) RNA binding .N/A
28 EBI-749265,EBI-10246897 RIPPLY2  
  .bone morphogenesis
.post-anal tail morphogenesis
.somite rostral/caudal axis specification
  + 5 more...
.N/A .nucleus
29 EBI-749265,EBI-3920969 MFSD5  
  .N/A .molybdate ion transmembrane transporter activity .integral component of membrane
.membrane
.plasma membrane
30 EBI-749265,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
31 EBI-749265,EBI-930143 CDC73  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
32 EBI-749265,EBI-1052114 LARP1  
  .positive regulation of translation
.TOR signaling
.positive regulation of macroautophagy
  + 2 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.translation initiation factor binding
  + 4 more...
.membrane
.cytoplasm
.nucleoplasm
33 EBI-749265,EBI-2804156 OLFM4  
  .positive regulation of substrate adhesion-dependent cell spreading
.protein homooligomerization
.negative regulation of immune response
  + 2 more...
.cadherin binding
.protein homodimerization activity
.catalytic activity
.extracellular exosome
.perinuclear region of cytoplasm
.specific granule
  + 3 more...
34 EBI-749265,EBI-10256202 RSRC2  
  .N/A .poly(A) RNA binding .N/A
35 EBI-749265,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
36 EBI-749265,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
37 EBI-749265,EBI-10265825 TMEM199  
  .N/A .N/A .integral component of membrane
38 EBI-749265,EBI-10266796 JAGN1  
  .neutrophil migration
.defense response to fungus
.granulocyte colony-stimulating factor signaling pathway
  + 6 more...
.N/A .integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
39 EBI-749265,EBI-749270 SERP2  
  .protein transport .N/A .integral component of membrane
.endoplasmic reticulum membrane
40 EBI-749265,EBI-2820517 LHFPL5  
  .auditory receptor cell stereocilium organization
.detection of mechanical stimulus involved in sensory perception of sound
.ion transport
.N/A .stereocilium bundle tip
.apical plasma membrane
.integral component of membrane
41 EBI-749265,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
42 EBI-749265,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
43 EBI-749265,EBI-726510 LENG1  
  .N/A .N/A .N/A
44 EBI-749265,EBI-10288884 TMEM41A  
  .N/A .N/A .integral component of membrane
45 EBI-749265,EBI-10290130 SLC41A2  
  .transmembrane transport .cation transmembrane transporter activity .integral component of membrane
.plasma membrane
46 EBI-749265,EBI-10292696 CIB3  
  .N/A .calcium ion binding .N/A
47 EBI-749265,EBI-10293349 ABHD1  
  .N/A .carboxylic ester hydrolase activity .integral component of membrane
48 EBI-749265,EBI-745182 TCF25  
  .heart development
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
49 EBI-749265,EBI-2680384 C17orf62  
  .N/A .N/A .integral component of membrane
50 EBI-749265,EBI-8644112 SLC30A2  
  .positive regulation of sequestering of zinc ion
.transmembrane transport
.zinc II ion transport
.cation transmembrane transporter activity .integral component of membrane
.late endosome
.lysosomal membrane
.cytoplasm
51 EBI-749265,EBI-714881 SENP2  
  .regulation of G1/S transition of mitotic cell cycle
.spongiotrophoblast layer development
.labyrinthine layer development
  + 21 more...
.SUMO-specific protease activity .nuclear membrane
.cytoplasmic vesicle
.PML body
  + 2 more...
52 EBI-749265,EBI-10311735 NRIP3  
  .N/A .aspartic-type endopeptidase activity .N/A
53 EBI-749265,EBI-8640191 SMCO4  
  .N/A .N/A .integral component of membrane
54 EBI-749265,EBI-10313040 TMPRSS4  
  .proteolysis .scavenger receptor activity
.serine-type endopeptidase activity
.integral component of membrane
55 EBI-749265,EBI-722397 RNF146  
  .positive regulation of canonical Wnt signaling pathway
.protein K48-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.poly-ADP-D-ribose binding
.ubiquitin protein ligase activity
.ligase activity
  + 2 more...
.cytosol
.nucleus
56 EBI-749265,EBI-10317612 MARCH2  
  .protein ubiquitination
.endocytosis
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasmic vesicle
.integral component of membrane
.endosome membrane
  + 3 more...
57 EBI-749265,EBI-2339195 TMEM14C  
  .heme biosynthetic process .N/A .mitochondrial membrane
.integral component of membrane
58 EBI-749265,EBI-356517 BAG5  
  .negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.regulation of cellular response to heat
.regulation of inclusion body assembly
  + 7 more...
.chaperone binding
.ubiquitin protein ligase binding
.protein kinase binding
.perinuclear region of cytoplasm
.inclusion body
.membrane
  + 3 more...
59 EBI-749265,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
60 EBI-749265,EBI-2866431 ITM2B  
  .extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of amyloid precursor protein biosynthetic process
.nervous system development
.ATP binding
.beta-amyloid binding
.extracellular exosome
.intracellular membrane-bounded organelle
.integral component of organelle membrane
  + 7 more...
61 EBI-749265,EBI-3385283 FIS1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein targeting to membrane
.positive regulation of mitochondrial fission
  + 15 more...
.receptor binding .protein complex
.integral component of mitochondrial outer membrane
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain6
lung5
lymph22
muscle18
testis156
thymus25
uterus4
Health State
TissuesTPM*
normal12
lung tumor19
lymphoma13
uterine tumor11
Developmental Stage
TissuesTPM*
adult5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
pancreas1.3
testis50.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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