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> Protein (NX_Q8N6Y0)
Protein (NX_Q8N6Y0)
Protein
Gene SymbolUSHBP1 to neXtProt (NX_Q8N6Y0)
DescriptionUsher syndrome type-1C protein-binding protein 1
Chromosome19
Location19p13.11 (17359985 ~ 17393595) to Ensembl
Sequene Features : Isoforms 2, Variants 135, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .PDZ domain binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 135 0
2014-09-19protein level
2 104 0
2014-05-27protein level
2 104 0
2014-02-25protein level
2 104 0
2013-12-09protein level
2 78 0
2013-11-01protein level
2 74 0
2013-09-12protein level
2 74 0
2013-08-17protein level
2 74 0
2013-07-15protein level
2 59 0
2013-06-11protein level
2 59 0
2013-02-12protein level
2 30 0
2012-12-20protein level
2 30 0
2012-10-30protein level
2 33 0
2012-10-07protein level
2 33 0
2012-08-24protein level
2 23 0
2012-07-28protein level
2 23 0
2012-06-08protein level
2 28 0
2012-05-07protein level
2 25 0
2012-04-10protein level
2 25 0
2012-01-13protein level
2 14 0
2011-12-20protein level
2 14 0
2011-11-11protein level
2 14 0
2011-08-23protein level
2 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N6Y0-1
27 1 0 76021.2782
NX_Q8N6Y0-2
0 1 0 7009.4344
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739895,EBI-749204 BET1  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.N/A .Golgi cisterna
.integral component of membrane
.membrane
  + 3 more...
2 EBI-739895,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
3 EBI-739895,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
4 EBI-739895,EBI-3943153 CCDC22  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.cullin family protein binding .endosome
5 EBI-739895,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
6 EBI-739895,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
7 EBI-739895,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
8 EBI-739895,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
9 EBI-739895,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
10 EBI-739895,EBI-713279 FTL  
  .membrane organization
.transmembrane transport
.iron ion homeostasis
  + 4 more...
.identical protein binding
.ferric iron binding
.iron ion binding
.extracellular exosome
.membrane
.intracellular ferritin complex
.cytosol
11 EBI-739895,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
12 EBI-739895,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
13 EBI-739895,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
14 EBI-739895,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
15 EBI-739895,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
16 EBI-739895,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
17 EBI-739895,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
18 EBI-739895,EBI-1049004 SYNJ2BP  
  .N/A .N/A .integral component of membrane
.mitochondrial outer membrane
.mitochondrion
19 EBI-739895,EBI-741753 NGFRAP1  
  .apoptotic signaling pathway
.neurotrophin TRK receptor signaling pathway
.regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 3 more...
.metal ion binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.cytosol
.cytoplasm
.nucleus
20 EBI-739895,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
21 EBI-739895,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
22 EBI-739895,EBI-396563 PPP2R5D  
  .canonical glycolysis
.stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
  + 20 more...
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.cytosol
.nucleoplasm
.nucleus
.protein phosphatase type 2A complex
23 EBI-739895,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
24 EBI-739895,EBI-1024281 PPP1R7  
  .regulation of catalytic activity
.positive regulation of protein dephosphorylation
.chromosome segregation
.enzyme regulator activity
.protein phosphatase type 1 regulator activity
.extracellular exosome
.cytoplasm
.chromosome
.nucleus
25 EBI-739895,EBI-2805604 KIAA0753  
  .N/A .N/A .centrosome
.cytoplasm
26 EBI-739895,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
27 EBI-739895,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
28 EBI-739895,EBI-2372238 RNF20  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
29 EBI-739895,EBI-2514135 KRT79  
  .N/A .enzyme binding
.structural molecule activity
.extracellular exosome
.keratin filament
30 EBI-739895,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
31 EBI-739895,EBI-10247000 NCAPH2  
  .chromosome condensation
.mitotic cell cycle
.N/A .membrane
.chromosome
.nucleoplasm
32 EBI-739895,EBI-10250303 CENPP  
  .CENP-A containing nucleosome assembly
.small GTPase mediated signal transduction
.nucleosome assembly
.mitotic cell cycle
.N/A .cytosol
.nucleoplasm
.chromosome, centromeric region
33 EBI-739895,EBI-713832 PMF1  
  .cell division
.small GTPase mediated signal transduction
.mitotic nuclear division
  + 4 more...
.leucine zipper domain binding
.transcription coactivator activity
.cytosol
.transcription factor complex
.nucleus
.MIS12/MIND type complex
34 EBI-739895,EBI-2824523 THADA  
  .N/A .N/A .N/A
35 EBI-739895,EBI-2836982 CCDC121  
  .N/A .N/A .N/A
36 EBI-739895,EBI-9051024 CEP68  
  .centrosome organization
.protein localization to organelle
.centriole-centriole cohesion
.protein domain specific binding
.protein kinase binding
.cell junction
.microtubule organizing center
.centrosome
  + 3 more...
37 EBI-739895,EBI-9676069 ZNF765  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
38 EBI-739895,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
39 EBI-739895,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
40 EBI-739895,EBI-742102 EXOC8  
  .membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
41 EBI-739895,EBI-749051 C6orf165  
  .N/A .N/A .N/A
42 EBI-739895,EBI-744311 CCDC116  
  .N/A .N/A .centrosome
43 EBI-739895,EBI-1104933 CCDC24  
  .N/A .N/A .N/A
44 EBI-739895,EBI-10269984 CNNM3  
  .ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
45 EBI-739895,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
46 EBI-739895,EBI-2349862 CCDC148  
  .N/A .N/A .N/A
47 EBI-739895,EBI-747505 C1orf216  
  .N/A .N/A .N/A
48 EBI-739895,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
49 EBI-739895,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
50 EBI-739895,EBI-740680 DYDC1  
  .N/A .N/A .N/A
51 EBI-739895,EBI-923440 GATAD2B  
  .ATP-dependent chromatin remodeling
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.protein complex
.nuclear speck
.nucleoplasm
.nuclear chromatin
52 EBI-739895,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
53 EBI-739895,EBI-716589 UBE2W  
  .cellular response to misfolded protein
.protein K11-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
.nucleus
54 EBI-739895,EBI-726510 LENG1  
  .N/A .N/A .N/A
55 EBI-739895,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
56 EBI-739895,EBI-348259 MCRS1  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 6 more...
.N/A .MLL1 complex
.Ino80 complex
.cell junction
  + 5 more...
57 EBI-739895,EBI-10286106 LINC00526  
  .N/A .N/A .N/A
58 EBI-739895,EBI-1765605 THOC1  
  .negative regulation of DNA damage checkpoint
.negative regulation of isotype switching to IgA isotypes
.viral mRNA export from host cell nucleus
  + 11 more...
.RNA binding
.DNA binding
.intercellular bridge
.nuclear speck
.nuclear matrix
  + 6 more...
59 EBI-739895,EBI-10185348 CCDC120  
  .N/A .N/A .N/A
60 EBI-739895,EBI-5663129 INTS4  
  .snRNA processing .N/A .integrator complex
61 EBI-739895,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
62 EBI-739895,EBI-2510102 COPS8  
  .cullin deneddylation
.negative regulation of cell proliferation
.activation of NF-kappaB-inducing kinase activity
.N/A .extracellular exosome
.perinuclear region of cytoplasm
.COP9 signalosome
  + 3 more...
63 EBI-739895,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
64 EBI-739895,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
65 EBI-739895,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
66 EBI-739895,EBI-742413 COPS4  
  .cullin deneddylation
.protein deneddylation
.N/A .extracellular exosome
.cell junction
.COP9 signalosome
  + 3 more...
67 EBI-739895,EBI-395927 NOC4L  
  .rRNA processing
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nuclear membrane
.Noc4p-Nop14p complex
  + 3 more...
68 EBI-739895,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
69 EBI-739895,EBI-741626 FAM124B  
  .N/A .N/A .N/A
70 EBI-739895,EBI-10308083 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
71 EBI-739895,EBI-3921217 PARVG  
  .actin cytoskeleton reorganization
.cell-matrix adhesion
.actin binding .focal adhesion
.plasma membrane
.cytoskeleton
.cytoplasm
72 EBI-739895,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
73 EBI-739895,EBI-747082 CTNNBIP1  
  .negative regulation of mesenchymal cell proliferation
.negative regulation of transcription initiation from RNA polymerase II promoter
.negative regulation of smooth muscle cell proliferation
  + 10 more...
.armadillo repeat domain binding
.beta-catenin binding
.beta-catenin destruction complex
.cytosol
.cytoplasm
  + 2 more...
74 EBI-739895,EBI-949319 KLC4  
  .N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
75 EBI-739895,EBI-747481 IMP3  
  .rRNA processing .poly(A) RNA binding
.snoRNA binding
.Mpp10 complex
.small-subunit processome
.nucleolus
.nucleus
76 EBI-739895,EBI-749261 CCDC87  
  .cytokinesis
.microtubule cytoskeleton organization
.N/A .N/A
77 EBI-739895,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
78 EBI-739895,EBI-1774273 CTTNBP2NL  
  .negative regulation of transmembrane transport
.negative regulation of transporter activity
.protein dephosphorylation
.protein phosphatase 2A binding .actin cytoskeleton
.cytoplasm
79 EBI-739895,EBI-10320311 SEC14L4  
  .N/A .lipid binding
.transporter activity
.integral component of membrane
.intracellular
80 EBI-739895,EBI-359444 RASAL2  
  .negative regulation of Ras protein signal transduction
.positive regulation of GTPase activity
.signal transduction
.GTPase activator activity .intrinsic component of the cytoplasmic side of the plasma membrane
.cytoplasm
81 EBI-739895,EBI-748621 SERTAD3  
  .positive regulation of transcription, DNA-templated
.negative regulation of cell growth
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
82 EBI-739895,EBI-727424 VPS28  
  .positive regulation of ubiquitin-dependent endocytosis
.intracellular transport of virus
.membrane organization
  + 9 more...
.ubiquitin binding
.protein complex binding
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 6 more...
83 EBI-739895,EBI-1054270 MRPS23  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.poly(A) RNA binding
.structural constituent of ribosome
.intermediate filament cytoskeleton
.nuclear membrane
.ribosome
  + 2 more...
84 EBI-739895,EBI-347538 GPSM3  
  .regulation of G-protein coupled receptor protein signaling pathway .GDP-dissociation inhibitor activity .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
brain13
connective tissue6
eye19
heart33
intestine4
kidney14
lung11
mammary gland13
mouth30
pancreas4
placenta24
prostate10
spleen37
thymus12
uterus17
vascular19
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor10
colorectal tumor8
head and neck tumor7
non-neoplasia10
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult10
fetus5
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.6
adrenal gland1.4
appendix1.5
cerebral cortex1.3
colon1.7
duodenum1.7
esophagus1.5
gallbladder2.4
heart muscle6.3
kidney3.1
lung8.8
lymph node3
placenta8.1
prostate2.1
salivary gland1.9
skin1.5
small intestine2.1
spleen4.6
stomach1.3
testis1.2
thyroid gland2.6
urinary bladder2.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611810, gene) Ush1c-binding protein 1; USHBP1OMIM


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