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> Protein (NX_Q8N720)
Protein (NX_Q8N720)
Protein
Gene SymbolZNF655 to neXtProt (NX_Q8N720)
DescriptionZinc finger protein 655
Chromosome7
Location7q22.1 (99156029 ~ 99174076) to Ensembl
Sequene Features : Isoforms 4, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 86 1
2014-09-19protein level
4 68 1
2014-05-27protein level
4 68 1
2014-02-25protein level
4 66 3
2013-12-09protein level
4 47 3
2013-11-01protein level
4 45 3
2013-09-12protein level
4 45 3
2013-08-17protein level
4 45 3
2013-07-15protein level
4 33 3
2013-06-11protein level
4 33 3
2013-02-12protein level
4 21 8
2012-12-20protein level
3 21 7
2012-10-30protein level
3 27 7
2012-10-07protein level
3 27 3
2012-08-24protein level
3 26 3
2012-07-28protein level
3 26 3
2012-06-08protein level
3 27 3
2012-05-07protein level
3 25 3
2012-04-10protein level
3 25 3
2012-01-13protein level
3 9 3
2011-12-20protein level
3 9 3
2011-11-11protein level
3 9 3
2011-08-23protein level
3 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N720-1
1 23 0 57370.4935
NX_Q8N720-2
5 3 0 19992.0083
NX_Q8N720-3
2 23 0 61330.4399
NX_Q8N720-4
1 3 0 12029.0198
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-625509,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
2 EBI-625509,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
3 EBI-625509,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-625509,EBI-394678 MED21  
  .positive regulation of transcription from RNA polymerase II promoter
.stem cell maintenance
.regulation of transcription from RNA polymerase II promoter
  + 2 more...
.DNA-directed RNA polymerase activity
.transcription coactivator activity
.mediator complex
5 EBI-625509,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-625509,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
7 EBI-625509,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
8 EBI-625509,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
9 EBI-625509,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder66
blood81
bone13
bone marrow20
brain81
cervix41
connective tissue20
ear186
embryonic tissue61
esophagus49
eye19
heart22
intestine64
kidney75
larynx127
liver34
lung113
lymph45
lymph node111
mammary gland39
mouth60
muscle94
nerve64
ovary19
pancreas60
parathyroid145
pituitary gland60
placenta42
prostate26
skin99
spleen37
stomach146
testis52
thymus125
thyroid107
trachea231
uterus90
vascular19
Health State
TissuesTPM*
normal60
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma36
colorectal tumor79
esophageal tumor57
gastrointestinal tumor101
germ cell tumor64
glioma93
head and neck tumor89
kidney tumor87
leukemia63
liver tumor31
lung tumor68
lymphoma110
non-neoplasia10
ovarian tumor26
pancreatic tumor66
primitive neuroectodermal tumor of the CNS39
retinoblastoma43
skin tumor151
soft tissue/muscle tissue tumor31
uterine tumor99
Developmental Stage
TissuesTPM*
adult67
embryoid body100
blastocyst65
neonate32
fetus32
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.4
adrenal gland29.6
appendix47.3
bone marrow52.3
cerebral cortex22.2
colon31.6
duodenum34.5
esophagus35.9
gallbladder30.9
heart muscle19.6
kidney28.3
liver15.7
lung38.7
lymph node51.6
ovary31
pancreas17.8
placenta30.4
prostate30.9
salivary gland25.3
skin47.3
small intestine35.3
spleen39.2
stomach35.7
testis24.1
thyroid gland31.4
urinary bladder35.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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