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> Protein (NX_Q8N726)
Protein (NX_Q8N726)
Protein
Gene SymbolCDKN2A to neXtProt (NX_Q8N726)
DescriptionCyclin-dependent kinase inhibitor 2A, isoform 4
Chromosome9
Location9p21.3 (21967751 ~ 21995300) to Ensembl
Sequene Features : Isoforms 2, Variants 148, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of protein targeting to mitochondrion
.negative regulation of proteolysis involved in cellular protein catabolic process
  + 33 more...
.MDM2/MDM4 family protein binding
.ubiquitin-protein transferase inhibitor activity
.transcription factor binding
  + 2 more...
.protein complex
.mitochondrion
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 148 0
2014-09-19protein level
2 142 0
2014-05-27protein level
2 142 0
2014-02-25protein level
2 132 0
2013-12-09protein level
2 131 0
2013-11-01protein level
2 131 0
2013-09-12protein level
2 131 0
2013-08-17protein level
2 131 0
2013-07-15protein level
2 131 0
2013-06-11protein level
2 131 0
2013-02-12protein level
2 131 0
2012-12-20protein level
1 131 0
2012-10-30protein level
1 131 0
2012-10-07protein level
1 131 0
2012-08-24protein level
1 13 0
2012-07-28protein level
1 13 0
2012-06-08protein level
1 15 0
2012-05-07protein level
1 15 0
2012-04-10protein level
1 15 0
2012-01-13protein level
1 15 0
2011-12-20protein level
1 15 0
2011-11-11protein level
1 15 0
2011-08-23protein level
1 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N726-1
2 3 0 13894.5672
NX_Q8N726-2
0 3 0 8725.5879
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-625922,EBI-878369 MYCN  
  .negative regulation of reactive oxygen species metabolic process
.branching morphogenesis of an epithelial tube
.negative regulation of astrocyte differentiation
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
.chromatin
2 EBI-625922,EBI-78579 NPM1  
  .regulation of eIF2 alpha phosphorylation by dsRNA
.regulation of endoribonuclease activity
.protein oligomerization
  + 20 more...
.unfolded protein binding
.NF-kappaB binding
.protein heterodimerization activity
  + 10 more...
.spindle pole centrosome
.ribonucleoprotein complex
.membrane
  + 7 more...
3 EBI-625922,EBI-2834611 EGR1  
  .negative regulation of canonical Wnt signaling pathway
.positive regulation of glomerular metanephric mesangial cell proliferation
.glomerular mesangial cell proliferation
  + 41 more...
.metal ion binding
.sequence-specific DNA binding
.histone acetyltransferase binding
  + 6 more...
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-625922,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
5 EBI-625922,EBI-347528 C1QBP  
  .positive regulation of dendritic cell chemotaxis
.positive regulation of trophoblast cell migration
.positive regulation of substrate adhesion-dependent cell spreading
  + 25 more...
.mitochondrial ribosome binding
.adrenergic receptor binding
.kininogen binding
  + 5 more...
.membrane
.cell surface
.plasma membrane
  + 7 more...
6 EBI-625922,EBI-625934 HUWE1  
  .positive regulation of protein targeting to mitochondrion
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cell differentiation
  + 4 more...
.poly(A) RNA binding
.ligase activity
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
7 EBI-625922,EBI-3923307 ZNF420  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.extracellular exosome
.nucleus
8 EBI-625922,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood8
bone27
brain22
cervix206
connective tissue6
embryonic tissue18
eye19
intestine90
kidney4
liver24
lung26
lymph90
lymph node44
mammary gland59
ovary88
pancreas42
placenta35
prostate47
salivary gland197
skin37
stomach10
testis13
uterus120
Health State
TissuesTPM*
normal11
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor289
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor92
germ cell tumor41
glioma167
head and neck tumor29
leukemia42
liver tumor10
lung tumor68
lymphoma96
ovarian tumor105
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer86
skin tumor63
soft tissue/muscle tissue tumor159
uterine tumor88
Developmental Stage
TissuesTPM*
adult22
embryoid body42
fetus10
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.4
adrenal gland3.2
appendix1.2
colon1.1
esophagus2.5
lung1.5
lymph node1.8
placenta1.9
prostate1.2
salivary gland1.1
small intestine2
spleen3.7
stomach3.3
testis5.7
urinary bladder1.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600160, gene) Cyclin-dependent kinase inhibitor 2a; CDKN2AOMIM
2melanoma;multiple other tumour types;pancreatic;Familial malignant melanomaCGP


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