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> Protein (NX_Q8N8B7)
Protein (NX_Q8N8B7)
Protein
Gene SymbolTCEANC to neXtProt (NX_Q8N8B7)
DescriptionTranscription elongation factor A N-terminal and central domain-containing protein
ChromosomeX
LocationXp22.2 (13671225 ~ 13700083) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 0
2014-09-19protein level
2 32 0
2014-05-27transcript level
2 32 0
2014-02-25transcript level
2 32 0
2013-12-09transcript level
2 28 0
2013-11-01transcript level
2 28 0
2013-09-12transcript level
2 28 0
2013-08-17protein level
2 28 0
2013-07-15protein level
2 18 0
2013-06-11protein level
2 18 0
2013-02-12protein level
2 10 0
2012-12-20protein level
2 9 0
2012-10-30protein level
2 11 0
2012-10-07protein level
2 11 0
2012-08-24transcript level
2 11 0
2012-07-28transcript level
2 11 0
2012-06-08transcript level
2 8 0
2012-05-07transcript level
2 8 0
2012-04-10transcript level
2 8 0
2012-01-13transcript level
2 2 0
2011-12-20transcript level
2 2 0
2011-11-11transcript level
2 2 0
2011-08-23transcript level
2 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N8B7-1
0 16 0 40219.0682
NX_Q8N8B7-2
2 16 0 43257.6498
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-954696,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-954696,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
3 EBI-954696,EBI-2515299 SSNA1  
  .ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
.organelle organization
  + 2 more...
.N/A .ciliary basal body
.cytosol
.centrosome
.nucleus
4 EBI-954696,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-954696,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
6 EBI-954696,EBI-1059030 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
7 EBI-954696,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
8 EBI-954696,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
9 EBI-954696,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
10 EBI-954696,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
11 EBI-954696,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
12 EBI-954696,EBI-978581 TARBP2  
  .negative regulation of defense response to virus by host
.regulation of viral transcription
.positive regulation of viral genome replication
  + 8 more...
.pre-miRNA binding
.protein homodimerization activity
.miRNA binding
  + 3 more...
.RISC-loading complex
.perinuclear region of cytoplasm
.micro-ribonucleoprotein complex
  + 5 more...
13 EBI-954696,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
14 EBI-954696,EBI-2562035 RNF219  
  .positive regulation of mRNA splicing, via spliceosome .zinc ion binding .N/A
15 EBI-954696,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
16 EBI-954696,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
17 EBI-954696,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
18 EBI-954696,EBI-10267893 CRACR2B  
  .regulation of store-operated calcium entry
.cellular protein localization
.store-operated calcium entry
.calcium ion binding .cytoplasm
19 EBI-954696,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
20 EBI-954696,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
21 EBI-954696,EBI-4311573 CSRNP1  
  .face morphogenesis
.palate development
.skeletal system morphogenesis
  + 4 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
22 EBI-954696,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
23 EBI-954696,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
24 EBI-954696,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone marrow20
brain2
intestine4
ovary9
pharynx24
skin9
testis4
uterus4
vascular19
Health State
TissuesTPM*
normal3
germ cell tumor3
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult1
fetus1
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
adrenal gland1.7
appendix2.9
bone marrow4.9
cerebral cortex1.8
colon2
duodenum1.8
esophagus1.5
gallbladder2.1
heart muscle2.3
kidney2.4
liver1
lung2.9
lymph node4.9
ovary4.2
placenta1.6
prostate2.2
salivary gland2.1
skin2
small intestine2.5
spleen4.4
stomach2.1
testis1.6
thyroid gland3.7
urinary bladder3.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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