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> Protein (NX_Q8N9N2)
Protein (NX_Q8N9N2)
Protein
Gene SymbolASCC1 to neXtProt (NX_Q8N9N2)
DescriptionActivating signal cointegrator 1 complex subunit 1
Chromosome10
Location10q22.1 (73856278 ~ 73976892) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA dealkylation involved in DNA repair
.DNA repair
.RNA binding .cytoplasm
.transcription factor complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 1
2014-09-19protein level
2 31 1
2014-05-27protein level
2 31 1
2014-02-25protein level
2 31 1
2013-12-09protein level
2 25 1
2013-11-01protein level
2 25 0
2013-09-12protein level
2 25 0
2013-08-17protein level
2 25 0
2013-07-15protein level
2 19 0
2013-06-11protein level
2 19 0
2013-02-12protein level
2 14 0
2012-12-20protein level
2 15 0
2012-10-30protein level
2 17 0
2012-10-07protein level
2 17 0
2012-08-24protein level
2 16 0
2012-07-28protein level
2 16 0
2012-06-08protein level
2 19 0
2012-05-07protein level
2 19 0
2012-04-10protein level
2 19 0
2012-01-13protein level
2 12 0
2011-12-20protein level
2 12 0
2011-11-11protein level
2 11 0
2011-08-23protein level
2 11 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8N9N2-1
3 12 0 45480.4817
NX_Q8N9N2-2
3 12 0 41201.4309
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10268317,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder66
blood122
bone13
brain78
cervix82
connective tissue93
embryonic tissue51
esophagus148
eye23
heart122
intestine34
kidney61
larynx85
liver38
lung23
lymph node55
mammary gland26
mouth15
muscle28
nerve64
ovary29
pancreas18
pharynx49
placenta24
prostate26
skin23
spleen131
stomach20
testis96
thymus112
trachea77
umbilical cord145
uterus68
vascular58
Health State
TissuesTPM*
normal62
adrenal tumor79
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma12
colorectal tumor17
esophageal tumor173
gastrointestinal tumor25
germ cell tumor87
glioma9
head and neck tumor14
kidney tumor72
leukemia105
liver tumor41
lung tumor38
lymphoma27
non-neoplasia93
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS110
prostate cancer48
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor103
uterine tumor44
Developmental Stage
TissuesTPM*
adult40
embryoid body28
blastocyst81
neonate160
fetus66
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.5
adrenal gland20.1
appendix15.7
bone marrow6.5
cerebral cortex21.9
colon12.1
duodenum10
esophagus15.8
gallbladder18.6
heart muscle23.5
kidney15.2
liver12.3
lung12.8
lymph node21.2
ovary18.2
pancreas10
placenta13
prostate14.5
salivary gland8.7
skin8.5
small intestine9.7
spleen17.5
stomach11.7
testis24.3
thyroid gland17.2
urinary bladder19.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614215, gene) Activating signal cointegrator 1 complex, subunit 1; ASCC1OMIM
2(#614266, phenotype) Barrett esophagusOMIM


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